TCL1A Products

Description

The T-cell leukaemia/lymphoma 1 (TCL1)-family oncoproteins augment AKT signal transduction and enhance cell proliferation and survival. Chromosome rearrangements, faulty developmental silencing and Epstein-Barr virus infection appear to dysregulate the expression of TCL1-family genes, provoking several important types of lymphocyte cancer. A key role for TCL1 proteins in cell transformation has been established in studies of transgenic mouse models, which develop a unique spectrum of T- and B-cell malignancies. How TCL1 proteins are regulated and dysregulated, how they promote transformation and the potential for therapies modelled on TCL1 interactions have important implications for understanding and treating lymphocyte cancers.

Bioinformatics

Entrez	8115 Human
Uniprot	P56279 Human
Product By Gene ID	8115
Alternate Names	Oncogene TCL1 Oncogene TCL-1 Protein p14 TCL1 T-cell leukemia/lymphoma 1A T-cell lymphoma-1 T-cell lymphoma-1A TCL1A TCL1-PEN TCL1T-cell leukemia/lymphoma protein 1A

Research Areas for TCL1A

Find related products by research area and learn more about each of the different research areas below.

Cancer