TCL1A Antibody (1-21)


Flow Cytometry: TCL1 Antibody (1-21) [NBP1-43253] - Staining of Daudi cells with 0.25 ug of Mouse IgG2b kappa Isotype Control Purified (open histogram) or 0.25 ug of Anti-Human TCL1 Purified (filled histogram) followed more

Product Details

Reactivity HuSpecies Glossary
Applications WB, Flow, IHC, IHC-P, IP
0.5 mg/ml

TCL1A Antibody (1-21) Summary

The immunogen for this antibody was TCL1.
IgG2b Kappa
Protein A or G purified
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Packaging, Storage & Formulations

Store at 4C. Do not freeze.
Aqueous buffer, may contain carrier protein/stabilizer (proprietary).
0.09% Sodium Azide
0.5 mg/ml
Protein A or G purified


Application Notes
This 1-21 antibody has been tested by western blot analysis of Daudi cell lysates and intracellular staining followed by flow cytometric analysis of Daudi cells. For flow cytometry, this can be used at less than or equal to 0.5 ug per test. Cell number should be determined empirically but can range from 10^5to 10^8cells/test.

Reactivity Notes

This antibody is reactive to Human.

Alternate Names for TCL1A Antibody (1-21)

  • Oncogene TCL1
  • Oncogene TCL-1
  • Protein p14 TCL1
  • T-cell leukemia/lymphoma 1A
  • T-cell lymphoma-1
  • T-cell lymphoma-1A
  • TCL1-PEN
  • TCL1T-cell leukemia/lymphoma protein 1A


The 1-21 antibody reacts with human T cell leukemia/lymphoma 1 (TCL1), a 14 kDa proto-oncogene product with a suggested role in intracellular regulation of T cell signalling. TCL1 was identified as the oncogene located at the 14q32.1 chromosome breakpoint region in T-cell prolymphocytic leukemia (T-PLL). In T-PLL, TCL1 is overexpressed as a result of an inversion or a reciprocal translocation, by juxtaposition to the T-cell receptor promoter/enhancer elements. TCL1 binds to the pleckstrin homology domain of Akt (protein kinase B) family proteins, which facilitates Akt dimerization and activity. By increasing Akt activity TCL1 may enhance the serine/threonine phosphorylation of major Akt signaling substrates, such as Ikk complex, mTOR, BAD, p70S6 kinase, FOXO transcription factors, and GSK3beta. These substrates regulate cellular differentiation, growth, survival, and metabolism. Besides its tumorigenic role in T-PLL, TCL1 is normally expressed in the CD3-CD4-CD8- subset of thymic precursors in the T cell lineage, the plasmacytoid subset of dendritic cells, stimulated (not resting) mature T cells, and B cells up to the germinal center stage of maturation. TCL1 is inappropriately expressed by chromosome rearrangements that lead to pre-malignant clonal T cell expansions and mature T cell tumors. TCL1 shows a regulated expression pattern in chronic lymphocytic leukemia (CLL).


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor (R) 405 Labeled NBP1-43253AF405
Alexa Fluor (R) 488 Labeled NBP1-43253AF488
Alexa Fluor (R) 647 Labeled NBP1-43253AF647
Alexa Fluor (R) 700 Labeled NBP1-43253AF700
Allophycocyanin Labeled NBP1-43253APC
DyLight 350 Labeled NBP1-43253UV
DyLight 405 Labeled NBP1-43253V
DyLight 405LS Labeled NBP1-43253V3
DyLight 488 Labeled NBP1-43253G
DyLight 680 Labeled NBP1-43253FR
DyLight 755 Labeled NBP1-43253IR
PE Labeled NBP1-43253PE
PerCP Labeled NBP1-43253PCP

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Contact Information

Product PDFs


Gene Symbol TCL1A

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