TCF7L2 Antibody [FITC]

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Product Details

Summary
Reactivity Hu, Mu, BvSpecies Glossary
Applications ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
FITC

TCF7L2 Antibody [FITC] Summary

Immunogen
Synthetic peptide made to an internal portion of human TCF7L2 (within residues 150-200). [Swiss-Prot# Q9NQB0]
Predicted Species
Mouse (93%), Bovine (93%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
TCF7L2
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence
Application Notes
This TCF7L2 antibody is useful for Immunocytochemistry/Immunofluorescence and Western blot, where a band is seen ~55 kDa. In ICC/IF cytoplasmic staining was observed.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
55 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human. Immunogen sequence has 93% homology to mouse and bovine.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for TCF7L2 Antibody [FITC]

  • HMG box transcription factor 4
  • hTCF-4
  • T-cell factor 4
  • T-cell factor-4 variant A
  • T-cell factor-4 variant B
  • T-cell factor-4 variant C
  • T-cell factor-4 variant D
  • T-cell factor-4 variant E
  • T-cell factor-4 variant H
  • T-cell factor-4 variant I
  • T-cell factor-4 variant J
  • T-cell factor-4 variant K
  • T-cell factor-4 variant L
  • T-cell factor-4 variant M
  • T-cell factor-4 variant X2
  • T-cell-specific transcription factor 4
  • TCF-4T-cell factor-4 variant F
  • TCF4T-cell factor-4 variant G
  • transcription factor 7-like 2 (T-cell specific, HMG-box)
  • transcription factor 7-like 2

Background

TCF7L2 (transcription factor 7-like 2, also called TCF4) is a key component in WNT signal transduction pathway which is implicated in several fundamental cellular processes such as embryonic development, stem cell maintenance, cellular fate, proliferation, survival, migration, tumour suppression, and oncogenesis. TCF7L2 gene codes for HMG- box transcription factor and through its critical role in WNT/beta-catenin signaling, it plays important role in cellular development as well as growth regulation. TCF7L2 participates in the process of blood glucose homeostasis via its regulatory effects on GLP-1 (glucagon-like peptide 1) and gene variants rs12255372 as well as rs7903146 have been documented to be associated with risk for NIDDM/Type 2 diabetes. TCF7L2 also regulates the transcription of proglucagon gene in enteroendocrine cells and has been suggested to be implicated in obesity also. TCF7L2 has been shown associate with human carcinogenesis specifically with triple negative i.e. ER, PR, HER2 negative or basal-like breast cancers.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for TCF7L2 Antibody (NBP1-19083F)

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Bioinformatics

Gene Symbol TCF7L2