TACI/TNFRSF13B/CVID Antibody [Biotin]

• Applications: WB, ELISA(Det)
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Biotin
• Concentration: LYOPH

TACI/TNFRSF13B/CVID Antibody [Biotin] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse TACI/TNFRSF13B
  Phe5-Thr129
  Accession # Q9ET35
• Specificity: Detects mouse TACI/TNFRSF13B in ELISAs and Western blots. In sandwich ELISAs, less than 0.1% cross-reactivity with recombinant human TACI and recombinant mouse BCMA is observed.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: TNFRSF13B
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Application Notes: ELISA Capture: Mouse TACI/TNFRSF13B Antibody (Catalog # MAB1041)
  ELISA Detection: Mouse TACI/TNFRSF13B Biotinylated Antibody (Catalog # BAF1041)
  Standard: Recombinant Mouse TACI/TNFRSF13B Fc Chimera (Catalog # 1041-TC)

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

TACI, transmembrane activator and CAML-interactor, is a member of the TNF receptor superfamily and has been designated TNFRSF13B. TACI is a type III membrane protein with an extracellular N-terminus in the absence of a cleaved signal sequence. The extracellular region of TACI contains two cysteine-rich domains. Within the TNFRSF, it shares the highest homology with B cell maturation factor (BCMA). TACI and BCMA have both been shown to bind APRIL and BAFF, members of the TNF ligand superfamily. TACI is expressed on the cell surface of B cells and activated, but not resting, T cells. Analogous to BCMA, data suggests that TACI may play an important role in B cell development, function and regulation. Mouse TACI is a 249 amino acid (aa) protein consisting of a 129 aa extracellular domain, a 20 aa transmembrane domain, and a 100 aa intracellular domain. Mouse and human TACI share 54% aa identity.

1. Xia, X.Z. et al. (2000) J. Exp. Med. 192:137.
2. von Bulow, G.U. et al. (1997) Science 278:138.
3. Gross, J.A. et al. (2000) Nature 404:995.
4. Marsters, S.A. et al. (2000) Curr. Biol. 10:785.
5. Yan, M. et al. (2000) Nature Immunol. 1:37.
6. Wu, Y. et al. (2000) J. Biol. Chem. 275:35478.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TNFRSF13B