TAB2 Antibody (3B5)

Western Blot: TAB2 Antibody (3B5) [NBP1-51668] - Western blot analysis using TAB2 mAb against HEK293 (1) and TAB2-hIgGFc transfected HEK293 (2) cell lysate.

Flow Cytometry: TAB2 Antibody (3B5) [NBP1-51668] - Flow cytometric analysis of HL-60 cells using TAB2 mouse mAb (green) and negative control (purple).

• Reactivity: Hu
• Applications: WB, ELISA, Flow
• Clone: 3B5
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated

TAB2 Antibody (3B5) Summary

• Immunogen: Purified recombinant fragment of human TAB2 expressed in E. Coli.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: TAB2
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • ELISA 1:10000
  • Flow Cytometry 1:200-1:400
  • Western Blot 1:500-1:2000
• Application Notes: This antibody is useful in Western Blot, ELISA, Flow Cytometry. Although not tested this antibody may be useful in Immunofluorescence/Immunocytochemistry.
• Theoretical MW: 80 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Ascites
• Preservative: 0.03% Sodium Azide
• Purity: Unpurified

Alternate Names for TAB2 Antibody (3B5)

• FLJ21885
• KIAA0733CHTD2
• MAP3K7IP2mitogen-activated protein kinase kinase kinase 7 interacting protein 2
• Mitogen-activated protein kinase kinase kinase 7-interacting protein 2
• TAB-2
• TAK1-binding protein 2
• TGF-beta activated kinase 1/MAP3K7 binding protein 2
• TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
• TGF-beta-activated kinase 1-binding protein 2

Background

The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TAB2