Stanniocalcin 2/STC-2 Antibody (2B11) - Azide and BSA Free

Western Blot: Stanniocalcin 2/STC-2 Antibody (2B11) [H00008614-M08] - Analysis of STC2 expression in PC-12.

Sandwich ELISA: Stanniocalcin 2/STC-2 Antibody (2B11) [H00008614-M08] - Detection limit for recombinant GST tagged STC2 is approximately 0.3ng/ml as a capture antibody.

• Reactivity: Hu, Rt
• Applications: WB, ELISA, IHC
• Clone: 2B11
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: Azide and BSA Free

Stanniocalcin 2/STC-2 Antibody (2B11) - Azide and BSA Free Summary

• Description: Quality control test: Antibody Reactive Against Recombinant Protein.
• Immunogen: STC2 (AAH00658, 1 a.a. ~ 302 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MCAERLGQFMTLALVLATFDPARGTDATNPPEGPQDRSSQQKGRLSLQNTAEIQHCLVNAGDVGCGVFECFENNSCEIRGLHGICMTFLHNAGKFDAQGKSFIKDALKCKAHALRHRFGCISRKCPAIREMVSQLQRECYLKHDLCAAAQENTRVIVEMIHFKDLLLHEPYVDLVNLLLTCGEEVKEAITHSVQVQCEQNWGSLCSILSFCTSAIQKPPTAPPERQPQVDRTKLSRAHHGEAGHHLPEPSSRETGRGAKGERGSKSHPNAHARGRVGGLGAQGPSGSSEWEDEQSEYSDIRR
• Specificity: STC2 (2B11)
• Isotype: IgG2b Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: STC2
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Sandwich ELISA
  • Western Blot
• Application Notes: Antibody reactivity against Recombinant Protein with GST tag on ELISA and WB. GST tag alone is used as a negative control.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: In 1x PBS, pH 7.4
• Preservative: No Preservative
• Purity: IgG purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Stanniocalcin 2/STC-2 Antibody (2B11) - Azide and BSA Free

• Stanniocalcin 2
• stanniocalcin-2
• STC2
• STC-2
• STC-2Stanniocalcin-related protein
• STC-related protein
• STCRP

Background

This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Stanniocalcin 2/STC-2 Antibody (H00008614-M08)(5)

Publications using H00008614-M08

• Na SS, Aldonza MB, Sung HJ et al. Stanniocalcin-2 (STC2): A potential lung cancer biomarker promotes lung cancer metastasis and progression. Biochim Biophys Acta. 2014-11-14 [PMID: 25463045]
• Miyazaki S, Kikuchi H, Iino I et al. Anti-VEGF antibody therapy induces tumor hypoxia and stanniocalcin 2 expression and potentiates growth of human colon cancer xenografts. Int J Cancer 2013-12-20 [PMID: 24375080] (WB, Human)
• Kita Y, Mimori K, Iwatsuki M et al. STC2: A Predictive Marker for Lymph Node Metastasis in Esophageal Squamous-Cell Carcinoma. Ann Surg Oncol 18(1):261-72. 2011-01-01 [PMID: 20734150]
• Halbert D, Domenyuk V, Spetzler D et al. Aptamers and uses thereof United States Patent Application US 9958448 B2 2018-01-01
• Yokobori T, Mimori K, Ishii H et al. Clinical Significance of Stanniocalcin 2 as a Prognostic Marker in Gastric Cancer. Ann Surg Oncol. 2010-04-27 [PMID: 20422456]

Bioinformatics

• Gene Symbol: STC2
• Entrez:
  • 8614(Human)
• OMIM:
  • 603665(Human)
• Uniprot:
  • AAH00658(Human)