STAMP2/STEAP4 Antibody (418714) [DyLight 650]

• Reactivity: Hu
• Applications: Flow, CyTOF-ready
• Clone: 418714
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: DyLight 650

STAMP2/STEAP4 Antibody (418714) [DyLight 650] Summary

• Immunogen: NS0 mouse myeloma cell line transfected with human STAMP2
  Met1-His459
  Accession # EAW76907
• Specificity: Detects human STAMP2-transfected NS0 cells but not irrelevant transfectants in flow cytometry.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: STEAP4
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • Flow Cytometry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for STAMP2/STEAP4 Antibody (418714) [DyLight 650]

• EC 1.16.1
• EC 1.16.1.-
• FLJ23153
• Six-transmembrane epithelial antigen of prostate 4
• SixTransMembrane protein of prostate 2
• STAMP2
• STAMP2DKFZp666D049
• STEAP family member 4
• STEAP4
• TIARP
• TIARPsix transmembrane prostate protein 2
• TNFAIP9
• Tumor necrosis factor, alpha-induced protein 9metalloreductase STEAP4
• tumor necrosis-alpha-induced adipose-related protein

Background

STEAP4 is a member of a family of metalloreductases identified as cell-surface antigens in prostate tissue. It is similar to two other members of the STEAP family, STEAP2 and STEAP3. STEAP4 promotes the reduction of both iron (Fe3+ to Fe2+) and copper (Cu2+ to Cu1+). STEAP4 is highly expressed in placenta, lung, heart and prostate tissues. Furthermore, it is over expressed in prostate cancer cells compared to normal prostate cells. STEAP4 may have a role in cell proliferation and prostrate cancer progression since over expression of STEAP4 in prostate cells significantly increases cell growth and colony formation. At least two isoforms of this protein are known to exist.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: STEAP4