STAMP2/STEAP4 Products

Description

STEAP4 is a member of a family of metalloreductases identified as cell-surface antigens in prostate tissue. It is similar to two other members of the STEAP family, STEAP2 and STEAP3. STEAP4 promotes the reduction of both iron (Fe3+ to Fe2+) and copper (Cu2+ to Cu1+). STEAP4 is highly expressed in placenta, lung, heart and prostate tissues. Furthermore, it is over expressed in prostate cancer cells compared to normal prostate cells. STEAP4 may have a role in cell proliferation and prostrate cancer progression since over expression of STEAP4 in prostate cells significantly increases cell growth and colony formation. At least two isoforms of this protein are known to exist.

Bioinformatics

Entrez	117167 Mouse 499991 Rat 79689 Human
Uniprot	EAW76907 Human NM_024636 Human NP_078912.2 Human Q687X5 Human
Product By Gene ID	79689
Alternate Names	EC 1.16.1 EC 1.16.1.- FLJ23153 Six-transmembrane epithelial antigen of prostate 4 SixTransMembrane protein of prostate 2 STAMP2DKFZp666D049 STEAP family member 4 TIARPsix transmembrane prostate protein 2 TNFAIP9 Tumor necrosis factor, alpha-induced protein 9metalloreductase STEAP4 tumor necrosis-alpha-induced adipose-related protein