SRPX2 Antibody - BSA Free

Western Blot: SRPX2 Antibody [NBP1-77370] - Human lung tissue lysate with SRPX2 antibody at (A) 1 and (B) 2 ug/mL.

Immunohistochemistry: SRPX2 Antibody - BSA Free [NBP1-77370] - Immunohistochemistry of SRPX2 in rat lung tissue with SRPX2 antibody at 5 ug/mL.

Immunocytochemistry/ Immunofluorescence: SRPX2 Antibody - BSA Free [NBP1-77370] - Immunofluorescence of SRPX2 in human lung tissue with SRPX2 antibody at 20 ug/mL.

• Reactivity: Hu, Mu, Rt, Bv
• Applications: WB, ELISA, ICC/IF, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

SRPX2 Antibody - BSA Free Summary

• Immunogen: Antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human SRPX2. The immunogen is located within the first 50 amino acids of SRPX2. Amino Acid Squence: SGYYPDESYNEVYAEE
• Predicted Species: Bovine (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: SRPX2
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence 20 ug/ml
  • Immunohistochemistry 5 ug/ml
  • Immunohistochemistry-Paraffin 5 ug/ml
  • Western Blot 1-2 ug/ml
• Control Peptide:

  SRPX2 Peptide (NBP1-77370PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for SRPX2 Antibody - BSA Free

• BPP
• CBPS
• RESDX
• SRPULPMGX
• sushi repeat-containing protein SRPX2
• sushi-repeat containing protein, X-linked 2
• sushi-repeat protein up-regulated in leukemia
• sushi-repeat-containing protein, X-linked 2

Background

Sushi-repeat-containing protein X-linked 2 (SRPX2) is a neural gene functioning in the speech and language center of the human brain; mutations in this gene lead to epilepsy, speech dyspraxia, mental retardation and cognitive disorders. Recently, SRPX2 was found to be a novel mediator of angiogenesis and can act as a ligand for the urokinase-type plasminogen activator, a protein that can facilitate invasive migration of sprouting endothelial cells. SRPX2 is also overexpressed in gastric cancer, leading to increased phosphorylation levels of focal adhesion kinase and enhanced cellular migration and adhesion, suggesting that SRPX2 may be a potential target in the treatment of metastatic cancers.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for SRPX2 Antibody (NBP1-77370)(1)

Publication using NBP1-77370

• Rippe C, Zhu B, Krawczyk KK et al. Hypertension reduces soluble guanylyl cyclase expression in the mouse aorta via the Notch signaling pathway. Sci Rep 2017-05-02 [PMID: 28465505] (WB, Human)
  
  Details:
  The anti-SRPX2 antibody NBP1-77370 from Novus was used to examine the effect of AngII and Nacl treatment on SPRX2 expression in mouse aortas

Bioinformatics

• Gene Symbol: SRPX2
• Uniprot:
  • NP_055282(Human)