SOX14 Antibody (1100814) [Alexa Fluor™ Plus 647]

• Reactivity: Hu
• Clone: 1100814
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 647

SOX14 Antibody (1100814) [Alexa Fluor™ Plus 647] Summary

• Specificity: Detects a synthetic peptide specific for human SOX14 around amino acid 190 in Direct ELISA.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for SOX14 Antibody (1100814) [Alexa Fluor™ Plus 647]

• HMG box transcription factor SOX-14
• MGC119898
• MGC119899
• SOX14
• SOX28
• SRY (sex determining region Y)-box 14
• SRY-box 14
• transcription factor SOX-14

Background

SOX14 is a 36 kDa protein that belongs to the SOX (SRY-related HMG-box) family of transcription factors. It plays a crucial role in the development and differentiation of the central nervous system and is critically involved in the regulation of embryogenesis, neural differentiation, and the development of specific neuronal populations. Aberrant expression or mutations of SOX14 have been associated with developmental disorders, including speech and cognitive impairments, as well as various cancers such as medulloblastoma and glioblastoma where it impacts cell proliferation, migration, and survival pathways. SOX14 is also essential for proper neural crest cell development and is implicated in neural tube defects when dysregulated. This makes it an important biomarker for neurological development and related pathologies.

1. Yao L, Zhang J, Xing B, Chen F, Zhang G, Teng Q, Jin J. SOX14 promotes glioma cell proliferation and invasion by suppressing p53 signaling. Oncotarget. 2018 Jun 12;9(45):27646-27657. doi: 10.18632/oncotarget.25542. PMID: 29983854; PMCID: PMC6029639. 
2. Smit R, Louw S, Stevens J, Kay V. SOX14 is critical for neural crest cell differentiation and neural tube closure in murine embryonic development. J Neurosci Res. 2021 May;99(5):1131-1140. doi: 10.1002/jnr.24759. PMID: 33577345; PMCID: PMC8489940.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.