SLC6A4/5-HTTLPR/Serotonin transporter [p Thr276] Antibody

Western Blot: SLC6A4/5-HTTLPR/Serotonin transporter [p Thr276] Antibody [NBP2-60778] - Western blot of rat mid brain membrane lysate showing specific immunolabeling of the ~76 kDa SERT protein phosphorylated at Thr276 in the first lane (-). Phosphospecificity is shown in the second lane (+) where immunolabeling is blocked by preadsorption of the phosphopeptide used as antigen, but not by the corresponding non-phosphopeptide (not shown).

• Reactivity: Mu, Rt, Hu, Bv, Pm, Sh, Xp
• Applications: WB
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated

SLC6A4/5-HTTLPR/Serotonin transporter [p Thr276] Antibody Summary

• Immunogen: Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr276 conjugated to KLH. Accession # P31652
• Modification: p Thr276
• Specificity: Specific for endogenous levels of the ~76 kDa SLC6A4/5-HTTLPR/Serotonin transporter protein phosphorylated at Thr276. Immunolabeling is blocked by preadsorption with the phosphopeptide used as antigen, but not by the corresponding non-phosphopeptide.
• Predicted Species: Human (100%), Sheep (100%), Xenopus (100%), Primate (100%), Bovine (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: SLC6A4
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:100-1:2000
• Theoretical MW: 76 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: 10 mM HEPES (pH 7.5), 0.15 M NaCl, 0.1 mg/mL BSA, 50% Glycerol
• Preservative: No Preservative
• Purity: Antigen Affinity-purified

Alternate Names for SLC6A4/5-HTTLPR/Serotonin transporter [p Thr276] Antibody

• 5HT transporter
• 5-HT Transporter
• 5-HTT
• 5HTTLPR
• 5-HTTLPR
• hSERT
• HTT5-hydroxytryptamine transporter
• Na+/Cl- dependent serotonin transporter
• OCD1
• Serotonin Transporter 1
• SERT
• SLC6A4
• sodium-dependent serotonin transporter
• solute carrier family 6 (neurotransmitter transporter, serotonin), member 4,5-HTTLPR
• Solute carrier family 6 member 4,5HTT

Background

Serotonin transporter encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SLC6A4