SLC6A4/5-HTTLPR/Serotonin transporter Antibody (SR2165)

Western Blot: SLC6A4/5-HTTLPR/Serotonin transporter Antibody (SR2165) [NBP3-21914] - Western blot analysis using NBP3-21914 in Human fetal liver lysate.

• Reactivity: Hu, Mu, Rt
• Applications: WB
• Clone: SR2165
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Unconjugated

SLC6A4/5-HTTLPR/Serotonin transporter Antibody (SR2165) Summary

• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: A synthesized peptide derived from human SLC6A4/5-HTTLPR/Serotonin transporter (Uniprot #: P31645)
• Specificity: Detects endogenous levels of total SLC6A4/5-HTTLPR/Serotonin transporter
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: SLC6A4
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:500-1:2000
• Theoretical MW: 70 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -20 degrees C. Avoid freeze/thaw cycles.
• Buffer: PBS, pH 7.4, 150mM NaCl, 50% glycerol.
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for SLC6A4/5-HTTLPR/Serotonin transporter Antibody (SR2165)

• 5HT transporter
• 5-HT Transporter
• 5-HTT
• 5HTTLPR
• 5-HTTLPR
• hSERT
• HTT5-hydroxytryptamine transporter
• Na+/Cl- dependent serotonin transporter
• OCD1
• Serotonin Transporter 1
• SERT
• SLC6A4
• sodium-dependent serotonin transporter
• solute carrier family 6 (neurotransmitter transporter, serotonin), member 4,5-HTTLPR
• Solute carrier family 6 member 4,5HTT

Background

Serotonin transporter encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SLC6A4