SLC24A5 Antibody

Western Blot: SLC24A5 Antibody [NB100-40795] - Analysis of SLC24A5 using NB100-40795 in Mouse Eye lysate (35ug protein in RIPA buffer) at 2 ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence.

• Reactivity: Mu, Rt, Hu, Ca
• Applications: WB, ELISA
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: 0.5 mg/ml

SLC24A5 Antibody Summary

• Immunogen: Peptide with sequence TTPDCRKKFWKN corresponding to internal region according to NP_995322.1.
• Predicted Species: Human (100%), Canine (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: SLC24A5
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:2000
  • Western Blot 1 - 3 ug/ml
• Application Notes: WB: Approx. 40 kDa band observed in mouse eye and rat skin lysates is reported in scientific literature (PMID: 18166528).

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for SLC24A5 Antibody

• ion transporter JSX
• JSXsodium/potassium/calcium exchanger 5
• Na(+)/K(+)/Ca(2+)-exchange protein 5
• NCKX5solute carrier family 24 (sodium/potassium/calcium exchanger), member 5
• SHEP4
• Solute carrier family 24 member 5
• solute carrier family 24, member 5

Background

This gene is a member of the potassium-dependent sodium/calcium exchanger family and encodes an intracellular membrane protein with 2 large hydrophilic loops and 2 sets of multiple transmembrane-spanning segments. Sequence variation in this gene has been associated with differences in skin pigmentation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for SLC24A5 Antibody (NB100-40795)(2)

Publications using NB100-40795

• Ginger RS, Askew SE, Ogborne RM et al. SLC24A5 encodes a trans-Golgi network protein with potassium-dependent sodium-calcium exchange activity that regulates human epidermal melanogenesis. J Biol Chem 2008-02-01 [PMID: 18166528]
• Lamason RL, Mohideen MA, Mest JR et al. SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans. Science 2005-12-16 [PMID: 16357253]

Bioinformatics

• Gene Symbol: SLC24A5
• Entrez:
  • 283652(Human)
  • 317750(Mouse)
  • 311387(Rat)
• Uniprot:
  • NP_995322.1(Human)