SLC22A17 Antibody - BSA Free

Western Blot: SLC22A17 Antibody [NBP1-76918] - Analysis in SK-N-SH lysate with antibody at 0.5 ug/mL in (A) the presence and (B) the absence of blocking peptide.

Immunocytochemistry/ Immunofluorescence: SLC22A17 Antibody - BSA Free [NBP1-76918] - Immunofluorescence of SLC22A17 in rat kidney tissue tissue with SLC22A17 antibody at 20 ug/mL.

Immunocytochemistry/ Immunofluorescence: SLC22A17 Antibody - BSA Free [NBP1-76918] - Immunofluorescence of SLC22A17 in mouse kidney tissue with SLC22A17 antibody at 20 ug/ml.Green: Slc22A17 Antibody Blue: DAPI staining

Immunohistochemistry: SLC22A17 Antibody - BSA Free [NBP1-76918] - Immunohistochemistry of SLC22A17 in mouse kidney tissue with SLC22A17 antibody at 2.5 ug/ml.

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA, ICC/IF, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

SLC22A17 Antibody - BSA Free Summary

• Immunogen: Antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of the human Slc22A17. The immunogen is located within the last 50 amino acids of Slc22A17. Amino Acid Squence: CRRPSLLRQPPPTR
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: SLC22A17
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence 20 ug/ml
  • Immunohistochemistry 2.5 ug/mL
  • Immunohistochemistry-Paraffin 2.5 ug/mL
  • Western Blot 0.5 ug/ml
• Theoretical MW: 61 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• Control Peptide:

  SLC22A17 Peptide (NBP1-76918PEP)

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Bovine (86%)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for SLC22A17 Antibody - BSA Free

• 24p3R
• BOCTNGALR3
• BOIThBOIT
• Brain-type organic cation transporter
• Lipocalin-2 receptor
• Neutrophil gelatinase-associated lipocalin receptor
• NgalR
• NGALR2
• NGALRNGAL receptor
• potent brain type organic ion transporter
• solute carrier family 22 (organic cation transporter), member 17
• solute carrier family 22 member 17,24p3 receptor
• solute carrier family 22, member 17

Background

The Slc22 family of organic anion and cation transporters (OATs, OCTs, OCTNs) are transmembrane proteins expressed predominantly in kidney and liver. Each contain 12 predicted alpha-helical transmembrane domains (TMDs) and one large extracellular loop between TMDs 1 and 2. Transporters of the SLC22 family function in different ways such as uniporters that mediate facilitated diffusion in either direction (OCTs), as anion exchangers (OAT1, OAT3 and URAT1), and as Na(+)/l-carnitine cotransporter (OCTN2). Slc22 family members participate in the absorption and/or excretion of drugs, xenobiotics, and endogenous compounds in intestine, liver, and kidney, and perform homeostatic functions in brain and heart. Mutations in the Slc22 family may cause specific diseases such as primary systemic carnitine deficiency or idiopathic renal hypouricemia and may change drug absorption or excretion. Recent studies show the expression of Slc22A17 as receptor for Lipocalin 2 is relatively high in hematopoietic stem cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for SLC22A17 Antibody (NBP1-76918)(1)

Publication using NBP1-76918

• Li H, Liu Y, Liu Y et al. Tumor-associated astrocytes promote tumor progression of Sonic Hedgehog medulloblastoma by secreting lipocalin-2 Brain pathology (Zurich, Switzerland) 2023-09-18 [PMID: 37721122]

Bioinformatics

• Gene Symbol: SLC22A17
• Entrez:
  • 51310(Human)
• Uniprot:
  • Q8WUG5(Human)