SLC1A5 Antibody (3085B) [Alexa Fluor™ Plus 594]

• Reactivity: Hu
• Clone: 3085B
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Alexa Fluor Plus 594

SLC1A5 Antibody (3085B) [Alexa Fluor™ Plus 594] Summary

• Specificity: Detects a synthetic peptide specific for human SLC1A5 around amino acid 520 in Direct ELISA.
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for SLC1A5 Antibody (3085B) [Alexa Fluor™ Plus 594]

• AAAT
• Alanine/serine/cysteine transporter 2
• ASC amino acid transporter-2
• ASCT2
• ATB(0)
• ATBO
• baboon M7 virus receptor
• M7V1
• M7VS1
• neutral amino acid transporter B
• neutral amino acid transporter B(0)
• R16
• RD114 virus receptor
• RD114/simian type D retrovirus receptor
• RDR
• RDRC
• SLC1A5
• Sodium-dependent neutral amino acid transporter type 2
• solute carrier family 1 (neutral amino acid transporter), member 5
• Solute carrier family 1 member 5

Background

SLC1A5 is a sodium dependent antiporter also known as ASCT2 (ASC amino acid Transporter2). It is a member of the solute carrier (SLC) superfamily of transporters and plays an important role in tumors. It is one of the 3 proteins, including SLC7A5 and SLC3A2, that are among the highest differentially expressed genes in activated lymphocytes and cancerous cells. Pharmacological inhibition of SLC1A5 was found to abrogate the effector functions of NK cells. In a pancancer analysis of SLC1A5, it has been demonstrated to be a prognostic biomarker in cancer patients.

1. Nachef M, Ali AK, Almutairi SM, Lee SH. Targeting SLC1A5 and SLC3A2/SLC7A5 as a Potential Strategy to Strengthen Anti-Tumor Immunity in the Tumor Microenvironment. Front Immunol. 2021 Apr 19;12:624324. doi: 10.3389/fimmu.2021.624324. PMID: 33953707; PMCID: PMC8089370. 
2. Chen P, Jiang Y, Liang J, Cai J, Zhuo Y, Fan H, Yuan R, Cheng S, Zhang Y. SLC1A5 is a novel biomarker associated with ferroptosis and the tumor microenvironment: a pancancer analysis. Aging (Albany NY). 2023 Aug 10;15(15):7451-7475. doi: 10.18632/aging.204911. Epub 2023 Aug 10. PMID: 37566748; PMCID: PMC10457057.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.