SIRT6 Antibody [Biotin]

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Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit

SIRT6 Antibody [Biotin] Summary

Immunogen
A synthetic peptide made to a C-terminal region of the mouse SIRT6 protein (within residues 250-334). [Swiss-Prot P59941]
Localization
Nuclear
Clonality
Polyclonal
Host
Rabbit
Gene
SIRT6
Purity
Immunogen affinity purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Conjugate
Biotin
Format
Biotin (A=N/A, E=N/A)
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Applications/Dilutions

Dilutions
  • Western Blot 0.5-2 ug/ml
Application Notes
This SIRT6 antibody is useful for Western blot and Immunohistochemistry paraffin embedded sections. In Western blot a band is seen at ~37 kDa representing SIRT6, and a non-specific higher MW band can be seen at ~61 kDa. This antibody does not appear to detect the human protein in Western blot. In IHC-P, staining was observed in the nucleus of mouse testis. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended. Use in Immunocytochemistry/immunofluorescence reported in scientific literature (PMID: 23899523)

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
37 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Readout System

Reactivity Notes

Rat reactivity reported in scientific literature (PMID: 25288139) Immunogen sequence has 78% homology to human. Human reactivity reported in scientific literature (PMID: 25660418)

Alternate Names for SIRT6 Antibody [Biotin]

  • EC 3.5.1.-
  • NAD-dependent deacetylase sirtuin-6
  • SIR2L6sir2-related protein type 6
  • SIR2-like protein 6
  • sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)
  • sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 6
  • sirtuin 6
  • sirtuin type 6

Background

Sirtuins regulate epigenetic gene silencing. SIRT6 (Mono-ADP-ribosyltransferase sirtuin-6), a mouse Sir2 homolog, is a chromatin-associated nuclear ADP-ribosyltransferase protein. It appears to be involved in DNA repair and may also play a role in the ageing process.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for SIRT6 Antibody (NB100-2522B) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

DyLight 488 Labeled NB100-2522G
DyLight 550 Labeled NB100-2522R
DyLight 650 Labeled NB100-2522C
HRP Labeled NB100-2522H

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Blogs on SIRT6

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Contact Information

Product PDFs

Bioinformatics

Gene Symbol SIRT6

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