SIRT7 Antibody

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Western Blot: SIRT7 Antibody [NB100-56364] - Immunoblots reveal the levels of sirtuins (SIRT4-7) in the OSCC cell lines HSC-3, UM-SCC-1, and UM-SCC-17B and in normal human oral keratinocytes (K). B-Actin served as ...read more
Western Blot: SIRT7 Antibody [NB100-56364] - Analysis of SIRT7 in A) human liver and B) PBMC lysate using this antibody at 1 ug/ml.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

SIRT7 Antibody Summary

Immunogen
A mixture of synthetic peptides corresponding to amino acids 35-51 and 361-377 of human SIRT7 was used as immunogen.
Specificity
There is no corresponding 40 kD band seen in mouse or rat liver cell lysate.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SIRT7
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1-3 ug/ml
Publications
Read Publication using
NB100-56364 in the following applications:

  • WB
    1 publication

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein G purified

Alternate Names for SIRT7 Antibody

  • EC 3.5.1.-
  • MGC126840
  • MGC126842
  • silent mating type information regulation 2, S.cerevisiae, homolog 7
  • SIR2L7
  • SIR2L7NAD-dependent deacetylase sirtuin-7
  • SIR2-like protein 7
  • sir2-related protein type 7
  • sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae)
  • sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 7
  • Sirtuin 7
  • sirtuin type 7

Background

SIRT7 is a human member of a family of proteins called Sirtuins (Sir2-like proteins) and are present in prokaryotes and eukaryotes. All Sir2-like proteins have a sirtuin core domain, which contains a series of sequence motifs conserved in organisms ranging from bacteria to humans. Bacterial, yeast and mammalian sirtuins are able to metabolize NAD and possibly at as mono-ADP-ribosyltransferases. The enzymatic function of sirtuins is not yet completely understood but recent reports of histone-activated Sir2-mediated NAD metabolism and NAD-activated Sir2-mediated histone deacetylation suggest a possible coupled reciprocal activation mechanism involving interactions of Sir2 with NAD and the N epsilon-acetyl-lysine groups of acetylated histones.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for SIRT7 Antibody (NB100-56364)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.


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Secondary Antibodies

 

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Bioinformatics

Gene Symbol SIRT7
Uniprot