NB100-65530 recognizes rat CD172a, also known as Signal regulatory protein (SIRP). CD172a is expressed selectively by myeloid cells and by neurons. MRC OX-41 binds to a different epitope on SIRP than ED9. It does not block the interaction of CD172a - CD47.
Protein G purified
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Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS (pH 7.4)
0.09% Sodium Azide
Protein G purified
Alternate Names for SIRP alpha/CD172a Antibody (OX-41)
BITbrain-immunoglobulin-like molecule with tyrosine-based activation motifs
Brain Ig-like molecule with tyrosine-based activation motifs
CD172 antigen-like family member A
Inhibitory receptor SHPS-1
Macrophage fusion receptor
MFRtyrosine phosphatase SHP substrate 1
protein tyrosine phosphatase, non-receptor type substrate 1
SHP substrate 1
signal-regulatory protein alpha
Signal-regulatory protein alpha-1
Signal-regulatory protein alpha-2
Signal-regulatory protein alpha-3
SIRPtyrosine-protein phosphatase non-receptor type substrate 1
Protein tyrosine phosphatases (PTPases) SHP1 and SHP2 are critical regulators in the intracellular signaling pathways that result in cell responses such as mitosis, differentiation, migration, survival, transformation or death. SHP2 is a signal transducer for several receptor tyrosine kinases and cytokine receptors. A novel SHP2 associated glycoprotein was recently cloned from human, rat, mouse and cattle by several labs and was designated SIRPa (1),SHPS1, MyD1, BIT and p84. SIRPa is a new gene family containing at least fifteen members. SIRPa is a substrate of many activated tyrosine kinases such as insulin receptor, EGFR, PDGFR and src, and a specific docking protein for SHP2. SIRPa has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones and cell adhesion and plays a general role in different physiological and pathological processes.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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