Western Blot: Sin1/MAPKAP1 Antibody [NB110-40424] - Detection of Human Sin1 on HeLa whole cell lysate.
Immunohistochemistry-Paraffin: Sin1/MAPKAP1 Antibody [NB110-40424] - Section of human prostate carcinoma. Antibody: Affinity purified rabbit anti- Sin1 used at a dilution of 1:1,000 (1ug/ml). Detection: DAB
The immunogen recognized by this antibody maps to a region between residue 470 and the C-terminus (residue 522) of human stress-activated map kinase interacting protein 1 using the numbering given in entry NP_001006618.1 (GeneID 79109).
Mouse (100%), Rat (100%), Chicken (100%), Sheep (100%), Primate (100%), Bovine (100%). Backed by our 100% Guarantee.
Immunogen affinity purified
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Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE tissue sections.
59 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Mitogen-activated protein kinase 2-associated protein 1
mitogen-activated protein kinase associated protein 1
ras inhibitor MGC2745
SAPK-interacting protein 1
stress-activated map kinase interacting protein 1
Stress-activated map kinase-interacting protein 1
stress-activated protein kinase-interacting 1
target of rapamycin complex 2 subunit MAPKAP1
TORC2 subunit MAPKAP1
Sin1 is a novel component of the eukaryotic SAPK pathway. Sin1 and the H3 and H4 histones interact genetically, with the C terminus of Sin1 physically associating with components of the SWI-SNF complex. This interaction is blocked by the N-terminal half of the protein in full length Sin1. It has been proposed that Sin1 acts as a regulatable bridge between the SWI-SNF complex and the nucleosome Sin1 is also required for effective transcription via the AP-1 factor Pap1, but does not prevent its nuclear translocation. Sin1 is a novel component of the eukaryotic SAPK pathway.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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