Serpin B3/SCCA1 Antibody (886524) [Alexa Fluor® 405]

• Reactivity: Hu
• Applications: WB, IHC
• Clone: 886524
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 405

Serpin B3/SCCA1 Antibody (886524) [Alexa Fluor® 405] Summary

• Immunogen: S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Serpin B3/SCCA1
  Asn2-Pro390
  Accession # P29508
• Specificity: Detects human Serpin B3/SCCA1 in direct ELISAs and Western blots.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Serpin B3/SCCA1 Antibody (886524) [Alexa Fluor® 405]

• HsT1196
• Protein T4-A
• SCC
• SCCA
• SCCA1
• SCCA1SCCA-1
• SCCA-PD
• serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3
• Serpin B3
• serpin peptidase inhibitor, clade B (ovalbumin), member 3
• Squamous cell carcinoma antigen 1
• T4-A

Background

Serpin B3, also known as Squamous Cell Carcinoma Antigen-1 (SCCA1), is a member of the serpin superfamily of serine protease inhibitors (1). Serpins primarily inhibit serine proteases and some are known to inhibit caspases and papain-like cysteine proteases (1). Serpin B3 belongs to the subgroup ovalbumin-related serpins which are involved in the regulation of apoptosis, inflammation, angiogenesis and embryogenesis (2). Serpin B3 was initially isolated from human cervical squamous cell tissue. It is a tumor marker for squamous cell carcinomas in various areas including the cervix, head, neck and lung (3). Unlike typical serpins, Serpin B3 shows inhibitory activity against papain-like lysosomal cysteine proteases Cathepsin K, L, and S, while lacking inhibitory activity against serine proteases (4).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.