Serpin B3/SCCA1 Antibody (886524) [Alexa Fluor™ Plus 488]

• Reactivity: Hu
• Clone: 886524
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 488

Serpin B3/SCCA1 Antibody (886524) [Alexa Fluor™ Plus 488] Summary

• Specificity: Detects human Serpin B3/SCCA1 in direct ELISAs and Western blots.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Serpin B3/SCCA1 Antibody (886524) [Alexa Fluor™ Plus 488]

• HsT1196
• Protein T4-A
• SCC
• SCCA
• SCCA1
• SCCA1SCCA-1
• SCCA-PD
• serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3
• Serpin B3
• serpin peptidase inhibitor, clade B (ovalbumin), member 3
• Squamous cell carcinoma antigen 1
• T4-A

Background

Serpin B3, also known as Squamous Cell Carcinoma Antigen-1 (SCCA1), is a member of the serpin superfamily of serine protease inhibitors (1). Serpins primarily inhibit serine proteases and some are known to inhibit caspases and papain-like cysteine proteases (1). Serpin B3 belongs to the subgroup ovalbumin-related serpins which are involved in the regulation of apoptosis, inflammation, angiogenesis and embryogenesis (2). Serpin B3 was initially isolated from human cervical squamous cell tissue. It is a tumor marker for squamous cell carcinomas in various areas including the cervix, head, neck and lung (3). Unlike typical serpins, Serpin B3 shows inhibitory activity against papain-like lysosomal cysteine proteases Cathepsin K, L, and S, while lacking inhibitory activity against serine proteases (4).

1. Law, R. et al. (2006) Genome Biol. 7:216.
2. Benarafa, C. and Remold-O’Donnell, E. (2005) Proc. Natl. Acad. Sci. 102:11367.
3. Higgens, W.J. et al. (2010) J. Biol. Chem. 285:3722.
4. Schick, C. et al. (1998) Biochemistry. 37:5258.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.