Serpin A5/Protein C Inhibitor Antibody [Alexa Fluor™ Plus 647]

• Reactivity: Hu
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor Plus 647

Serpin A5/Protein C Inhibitor Antibody [Alexa Fluor™ Plus 647] Summary

• Specificity: Detects human Serpin A5/Protein C in direct ELISAs and Western blots. In direct ELISAs, less than 5% cross‑reactivity with recombinant human (rh) Serpin A1, rhSerpin A3, rhSerpin A4, rhSerpin A9, and rhSerpin A11 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Serpin A5/Protein C Inhibitor Antibody [Alexa Fluor™ Plus 647]

• Acrosomal serine protease inhibitor
• antitrypsin), member 5
• member 5
• PAI-3
• PAI3PLANH3
• PCI
• PCIplasminogen activator inhibitor III
• Plasminogen activator inhibitor 3
• plasminogen activator inhibitor-3
• PROCIplasma serine protease inhibitor
• Protein C inhibitor
• serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase
• Serpin A5
• serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin)
• SERPNA5

Background

Serpin A5 is the a member of the Serpin superfamily and inhibits a variety of serine proteases such as protein C, plasminogen activators, thrombin, factor Xa, several kallekreins and acrosin (1). Serpin A5 is synthesized in the liver and secreted in plasma. It is found in numerous steroid-responsive organs and has been detected in saliva, cerebral spinal fluid, amniotic fluid, tears and semen. Because of its protease targets and regulated expression patterns, Serpin A5 has been proposed to play a role in processes such as blood coagulation, fertilization and carcinogenesis (2, 3). Similar to Serpins C1 and D1, its thrombin inhibitory activity is enhanced by heparin.

1. Silverman, G.A. et al. (2001) J. Biol. Chem. 276:33293.
2. Palmier, D. et al. (2002) J. Biol. Chem. 277:40950.
3. Geiger, M. et al. (1996) Immunopharmacology 32:53.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.