SARM1 Antibody [mFluor Violet 450 SE]

• Reactivity: Hu
• Applications: WB, IP, ICC/IF
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: mFluor Violet 450 SE

SARM1 Antibody [mFluor Violet 450 SE] Summary

• Immunogen: E. coli-derived recombinant human SARM1
  Lys556-Thr724
  Accession # Q6SZW1
• Specificity: Detects human SARM1 in direct ELISAs and Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Gene: SARM1
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Immunoprecipitation
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for SARM1 Antibody [mFluor Violet 450 SE]

• KIAA0524SAM domain-containing protein 2
• SAMD2
• SAMD2sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila
• SARM1
• SARMFLJ36296
• Sterile alpha and Armadillo repeat protein
• sterile alpha and TIR motif containing 1
• sterile alpha and TIR motif-containing protein 1
• Sterile alpha motif domain-containing protein 2
• Tir-1 homolog

Background

Toll-like receptors (TLRs) play an essential role in the detection and elimination of invading microbes. They are type-1 transmembrane receptors, containing extracellular leucine rich repeats and an intracellular Toll/interleukin-1 receptor (TIR) domain. Upon stimulation, these receptors interact with specific TIR domain-containing adaptor proteins. Five such adaptors have been discovered to date, MyD88, Mal (MyD88 adaptor-like)/TIRAP (TIR domain-containing adaptor protein), Trif (TIR-domain-containing adaptor inducing interferon-beta), TRAM (Trif-related adaptor molecule) and SARM (SAM and ARM-containing protein). Different TLRs use different combinations of these adaptors, leading to the activation of common and unique pathways involved in the elimination of the invading microbe.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SARM1