SARM1 Products

Description

Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1-3). SARM (SAM and ARM-containing protein), along with other molecules such as TIRP, TRIF, TIRAP, and MyD88, is thought to serve as an adaptor protein for the TLRs that allows for the activation of downstream kinases and NF-kappaB, and ultimately the expression of proteins involved in host defense (4,5). While SARM has not been conclusively shown to associate directly with TLRs, the presence of a Toll-interluekin-1 (TIR) domain in SARM is consistent with a role as a signaling molecule (4,5).

Bioinformatics

Entrez	23098 Human 237868 Mouse
Uniprot	Q6SZW1 Human
Product By Gene ID	23098
Alternate Names	KIAA0524SAM domain-containing protein 2 SAMD2 SAMD2sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila SARM1 SARMFLJ36296 Sterile alpha and Armadillo repeat protein sterile alpha and TIR motif containing 1 sterile alpha and TIR motif-containing protein 1 Sterile alpha motif domain-containing protein 2 Tir-1 homolog

Research Areas for SARM1

Find related products by research area and learn more about each of the different research areas below.

Innate Immunity