ROR gamma/RORC/NR1F3 Antibody

Product Discontinued

ROR gamma/RORC/NR1F3 Antibody Summary

• Immunogen: Peptide with sequence CHLEYSPERGKAE corresponding to internal region according to NP_005051.2, NP_001001523.1.
• Specificity: This antibody is expected to recognize both reported isoforms (NP_005051.2; NP_001001523.1).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: RORC
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:16000
  • Western Blot 0.1-0.3 ug/ml
• Application Notes: WB: Approx. 55 kDa band observed in human colon lysates (calculated MW of 55.8 kDa band according to NP_001001523.1).

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Mouse, Canine, Bovine.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris (pH 7.3), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for ROR gamma/RORC/NR1F3 Antibody

• MGC129539
• NR1F3
• Nuclear receptor ROR gamma
• Nuclear receptor ROR-gamma
• Nuclear receptor RZR gamma
• Nuclear receptor RZR-gamma
• Nuclear receptor subfamily 1 group F member 3
• RAR-Related Orphan Nuclear Receptor Variant 2
• RAR-related orphan receptor C
• RAR-related orphan receptor gamma
• retinoic acid-binding receptor gamma
• retinoid-related orphan receptor gamma
• Retinoid-related orphan receptor-gamma
• ROR gamma
• RORC
• RORG
• RORGMGC129539
• RZRG
• RZRGRZR-GAMMA
• TOR

Background

ROR gamma/RORC/NR1F3, aka RAR Orphan Receptor gamma, is a Nuclear Receptor 1 Thyroid Hormone-Like receptor containing a short A-T rich sequence follow by a single core motif half-site 5'-AGGTCA-3'. RORC is a key regulator of thymopoiesis, bone metabolism, T-cell apoptosis, and lymphoid organogenesis. NR1F3 regulates intrinsic transcriptional functions. Unlike other major nuclear receptors, RORC binds as a monomer to hormone response elements and is documented in mouse thymus, adipose, bone, skeletal muscle, liver, kidney, and human skeletal muscle. An N-terminal isoform of ROR gamma, ROR gamma T, inhibits Fas ligand expression and cytokine secretion in immature thymocytes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for ROR gamma/RORC/NR1F3 Antibody (NBP1-72057)(1)

Publication using NBP1-72057

• Naito T, Shiohara T, Hibi T et al. ROR gamma t is dispensable for the development of intestinal mucosal T cells. Mucosal Immunol 2008-05-01 [PMID: 19079179]

FAQs for ROR gamma/RORC/NR1F3 Antibody (NBP1-72057). (Showing 1 - 3 of 3 FAQ).

1. Does ROR gamma/RORC/NR1F3 antibodies comes in lyophilized form?
   • Yes, we have 3 RORC antibodies delivere in lyophilized form: MAB61091, MAB61092, MAB6109.
2. What the theoretical molecular weight for ROR gamma/RORC/NR1F3 antibodies?
   • The TMW of ROR gamma/RORC/NR1F3 antibodies is approximately 56 - 60.
3. What is the immunogen sequence of this ROR gamma/RORC/NR1F3 antibody?
   • A sequence within the internal region (CHLEYSPERGKAE) of ROR gamma.

Bioinformatics

• Gene Symbol: RORC
• Entrez:
  • 6097(Human)
  • 19885(Mouse)
• Uniprot:
  • P51449()