ROR gamma/RORC/NR1F3 Products

Description

ROR gamma/RORC/NR1F3, aka RAR Orphan Receptor gamma, is a Nuclear Receptor 1 Thyroid Hormone-Like receptor containing a short A-T rich sequence follow by a single core motif half-site 5'-AGGTCA-3'. RORC is a key regulator of thymopoiesis, bone metabolism, T-cell apoptosis, and lymphoid organogenesis. NR1F3 regulates intrinsic transcriptional functions. Unlike other major nuclear receptors, RORC binds as a monomer to hormone response elements and is documented in mouse thymus, adipose, bone, skeletal muscle, liver, kidney, and human skeletal muscle. An N-terminal isoform of ROR gamma, ROR gamma T, inhibits Fas ligand expression and cytokine secretion in immature thymocytes.

Bioinformatics

Entrez	19885 Mouse 6097 Human
Uniprot	NM_001001523 Human NP_001001523.1 Human NP_005051 Human NP_005051.2 Human NP_005051.2 Human P51449 Human Q5SZR9 Human
Product By Gene ID	6097
Alternate Names	MGC129539 Nuclear receptor ROR gamma Nuclear receptor ROR-gamma Nuclear receptor RZR gamma Nuclear receptor RZR-gamma Nuclear receptor subfamily 1 group F member 3 RAR-Related Orphan Nuclear Receptor Variant 2 RAR-related orphan receptor C RAR-related orphan receptor gamma retinoic acid-binding receptor gamma retinoid-related orphan receptor gamma Retinoid-related orphan receptor-gamma ROR gamma RORG RORGMGC129539 RZRG RZRGRZR-GAMMA TOR

Research Areas for ROR gamma/RORC/NR1F3

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GPCR