The immunogen recognized by this antibody maps to a region between residues 500 and 550 of human Ring Finger and CCCH-type finder domains 1 using the numbering given in entry NP_742068.1 (GeneID 149041).
Porcine (100%), Primate (100%), Equine (100%)
Immunogen affinity purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
Based on 100% sequence identity, this antibody is predicted to react with Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, White-tufted-ear marmoset, Crab-eating macaque, African elephant, Naked mole rat, Thirteen-lined ground squirrel and Northern white-cheeked gibbon.
Alternate Names for Roquin Antibody
RING finger and C3H zinc finger protein 1
ring finger and CCCH-type domains 1
RING finger protein 198
RNF198ring finger and CCCH-type zinc finger domains 1
Roquin is a member of the RING-type E3 ubiquitin ligase protein family. It was recently found to contribute to autoimmune diseases such as type 1 diabetes and lupus. Research has found that a mutation in roquin causes T-cells to attack their own tissues. Roquin stops T-cells from displaying a stimulatory receptor, ICOS, that may cause the cells to attack normal body tissues. (1)
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.