RND3 Antibody (687202) [Alexa Fluor® 647]

• Applications: WB
• Clone: 687202
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 647

RND3 Antibody (687202) [Alexa Fluor® 647] Summary

• Immunogen: RND3 (RD1 peptide)
  Cys197-Arg207
  Accession # P61587
• Specificity: Detects human RND3 in direct ELISAs and Western blots.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

RND3, also known as RhoE, is an approximately 27 kDa member of the Rho family, small GTPase superfamily of molecules.  It is 244 amino acids (aa) in length, and the mature chain extends from aa 1-241.  RND3 is ubiquitously expressed and is involved in keratinocyte differentiation and stratification.  RND3 overexpression results in cell size enlargement and an increase in the number of stratified cells.  RND3 depletion results in hyperproliferation and delays initiation of keratinocyte differentiation.  Human RND3 shares 100% aa sequence identity with mouse RND3.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.