RND3 Products

Description

Members of the Rho family of Ras-related GTPases, such as ARHE, regulate the organization of the actin cytoskeleton in response to extracellular growth factors. Like Ras (MIM 190020), Rho family members appear to cycle between an inactive GDP-bound form and an active GTP-bound form. Three major regulators of Rho activity have been identified: RhoGDIs, which interact with the GDP-bound Rho proteins to keep them in a resting complex (see MIM 601925); GEFs, which promote GDP/GTP exchange leading to activation of Rho proteins (see MIM 601855); and GAPs, which stimulate GTP hydrolysis and return the activated Rho protein to its inactive form (see MIM 602680) (Nobes et al., 1998 [PubMed 9531558]).[supplied by OMIM]

Bioinformatics

Entrez	390 Human
Uniprot	NP_005159 Human
Product By Gene ID	390
Alternate Names	ARHE MemB Protein MemB Rho family GTPase 3member E Rho8 RHOE Rho-related GTP-binding protein Rho8 rho-related GTP-binding protein RhoE RND3 small GTP binding protein Rho8

Research Areas for RND3

Find related products by research area and learn more about each of the different research areas below.

Signal Transduction