RIMS3 Antibody - BSA Free

Western Blot: RIMS3 Antibody [NBP1-76874] - Human brain tissue lysate with Rims3 antibody at 1 ug/mL in the (A) absence and (B) presence of blocking peptide.

Immunocytochemistry/ Immunofluorescence: RIMS3 Antibody - BSA Free [NBP1-76874] - Immunofluorescence of rim3 in human brain tissue with rim3 antibody at 5 ug/mL.

Immunohistochemistry: RIMS3 Antibody - BSA Free [NBP1-76874] - Immunohistochemistry of RIMS3 in human brain tissue with RIMS3 antibody at 2.5 ug/mL.

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA, ICC/IF, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

RIMS3 Antibody - BSA Free Summary

• Immunogen: Antibody was raised against a 17 amino acid synthetic peptide from near the amino terminus of human Rim3. The immunogen is located within amino acids 60 - 110 of Rim3. Amino Acid Squence: LPQPEGATKKLRSNIRR
• Specificity: This antibody is predicted to have no cross-reactivity to other Rim proteins.
• Predicted Species: Rat (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: RIMS3
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence 5 ug/ml
  • Immunohistochemistry 2.5 ug/ml
  • Immunohistochemistry-Paraffin 2.5 ug/ml
  • Western Blot 1 ug/ml
• Control Peptide:

  RIMS3 Peptide (NBP1-76874PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for RIMS3 Antibody - BSA Free

• KIAA0137
• KIAA0237
• Nim3
• NIM3Rab-3 interacting molecule 3
• Rab-3-interacting molecule 3
• regulating synaptic membrane exocytosis 3
• regulating synaptic membrane exocytosis protein 3
• RIM 3
• RIM3 gamma
• RIM3

Background

Rab3-interacting molecules (RIMs) are synaptic proteins are synaptic proteins necessary for neural transmission and plasticity. While both Rim1 and Rim 2 are thought to be effector proteins for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner, less is known of Rim3. Expression of Rim3 in PC12 cells induced a significant increase in calcium-triggered exocytosis, with no appreciable change in the baseline release, suggesting that it plays a role in the regulation of exocytosis. Rim3 protein localizes primarily to neuronal dendrites and the postsynaptic densities, as opposed to Rim1 which is found in presynapse locations, indicating that Rim3 may contribute to synapse transmission and plasticity. This antibody is predicted to have no cross-reactivity to other Rim proteins.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: RIMS3
• Uniprot:
  • NP_055562(Human)