RIG-I Antibody

Images

 
Western Blot: RIG-I Antibody [NBP2-27419] - Analysis of 293 lysate in the 1) absence and 2) presence of immunizing peptide using RIG-I antibody at 3 ug/ml. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL ...read more
Immunohistochemistry-Paraffin: RIG-I Antibody [NBP2-27419] - Formalin-fixed, paraffin-embedded human breast stained with RIG-I antibody at 10 ug/ml.
Immunohistochemistry-Paraffin: RIG-I Antibody [NBP2-27419] - Formalin-fixed, paraffin-embedded human uterus stained with RIG-I antibody at 10 ug/ml.

Product Details

Summary
Reactivity Hu, PmSpecies Glossary
Applications WB, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

RIG-I Antibody Summary

Immunogen
A portion of amino acid 200-250 of human RIG-I was used as the immunogen.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
DDX58
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 2-4ug/ml~
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 5-10ug/ml
Publications
Read Publication using NBP2-27419.

Reactivity Notes

The amino acid sequence used as immunogen for the RIG-I antibody is 100% homologous in human and monkey, 78% homologous in mouse and 82% homologous in rat.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
0.1 ml PBS
Preservative
0.02% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for RIG-I Antibody

  • DDX58
  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
  • DEAD box protein 58
  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide
  • DKFZp686N19181
  • EC 3.6.4.13
  • FLJ13599
  • probable ATP-dependent RNA helicase DDX58
  • retinoic acid inducible gene I
  • Retinoic acid-inducible gene 1 protein
  • Retinoic acid-inducible gene I protein
  • RIG-1
  • RIGI
  • RIG-I
  • RIG-IDKFZp434J1111
  • RNA helicase RIG-I

Background

RIG-I belongs to the Helicase family and contains two CARD domains, one helicase ATP-binding domain and one helicase C-terminal domain. It is involved in innate immune defense against viruses. It triggers a transduction cascade involving MAVS/IPS1 which leads to activation of NF-kappa-B, IRF3 and IRF7 inducing expression of antiviral cytokines such as INF-beta and RANTES (CCL5) during viral replication. Reports also says that TLR3 and RIG-like receptor on myeloid dendritic cells and Rig-like receptor on human Nk cells are both required for production of IFN-gamma in response to double-stranded RNA during viral infection.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol DDX58
Uniprot
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