Recombinant Mouse TRANCE/RANK L/TNFSF11 (E. coli-expressed)

Recombinant Mouse TRANCE/TNFSF11/RANK L (Catalog # 462-TEC) induces osteoclast differentiation of the RAW 264.7 mouse monocyte/macrophage cell line. The ED50 for this effect is 0.5-2 ng/mL.

1 μg/lane of Recombinant Mouse TRANCE/TNFSF11/RANK L was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 19 kDa.

• Reactivity: Mu
• Applications: Bioactivity

Recombinant Mouse TRANCE/RANK L/TNFSF11 (E. coli-expressed) Summary

• Details of Functionality: Measured by its ability to induce osteoclast differentiation of RAW 264.7 mouse monocyte/macrophage cells. The ED₅₀ for this effect is 0.5‑2 ng/mL.
• Source: E. coli-derived mouse TRANCE/TNFSF11/RANK L protein
  Lys158-Asp316, with an N-terminal Met
• Accession #: Q3TWY5
• N-terminal Sequence: Met
• Protein/Peptide Type: Recombinant Proteins
• Gene: Tnfsf11
• Purity: >95%, by SDS-PAGE under reducing conditions and visualized by silver stain
• Endotoxin Note: <0.01 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 19 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in NaH₂PO₄, NaCl and EDTA with BSA as a carrier protein.
• Purity: >95%, by SDS-PAGE under reducing conditions and visualized by silver stain
• Reconstitution Instructions: Reconstitute at 100 μg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse TRANCE/RANK L/TNFSF11 (E. coli-expressed)

• CD254 antigen
• CD254
• ODF
• OPGL
• OPGLOPTB2
• Osteoclast differentiation factor
• Osteoprotegerin ligand
• RANK L
• RANKL
• RANKLreceptor activator of nuclear factor kappa B ligand
• Receptor activator of nuclear factor kappa-B ligand
• sOdf
• TNF-related activation-induced cytokine
• TNFSF11
• TRANCE
• TRANCEODFhRANKL2
• tumor necrosis factor (ligand) superfamily, member 11
• tumor necrosis factor ligand superfamily member 11

Background

TRANCE (receptor activator of NF-kappa B ligand [RANK L], also called TNF-related activation-induced cytokine [TRANCE], osteoprotegrin ligand [OPGL], and osteoclast differentiation factor [ODF]), is a member of the tumor necrosis factor (TNF) family. TRANCE was originally identified as an immediate early gene up-regulated by T cell receptor stimulation. The mouse TRANCE cDNA encodes a type II transmembrane protein of 316 amino acids with a predicted cytoplasmic domain of 48 amino acids and an extracellular domain of 247 amino acids. The extracellular domain contains two potential N-linked glycosylation sites. Mouse and human TRANCE share 85% amino acid identity. TRANCE is primarily expressed in T cells and T cell rich organs, such as thymus and lymph nodes. The multi-functions of TRANCE include induction of activation of the c-jun N-terminal kinase, enhancement of T cell growth and dendritic cell function, induction of osteoclastogenesis, and lymph node organogenesis. RANK is the cell surface signaling receptor of TRANCE. RANK has been shown to undergo receptor clustering during signal transduction. Osteoprotegrin, a soluble member of the TNF receptor family which binds TRANCE, is a naturally occurring decoy receptor that counterbalances the effects of TRANCE.

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2. Anderson, D.M. et al. (1997) Nature 390:175.
3. Nakagawa, N. et al. (1998) Biochem. Biophys. Res. Commun. 245:382.
4. Kong, Y-Y. et al. (1999) Nature 397:315.

Publications for TRANCE/TNFSF11/RANK L (462-TEC)(106)

Publications using 462-TEC

• Yuan, H;Bao, Y;Li, L;Luan, Y;Li, F; A novel HDAC1-specific inhibitor prevents estrogen deficiency-induced osteoporosis in mice by inhibiting osteoclast function Archives of gerontology and geriatrics 2025-08-29 [PMID: 40907258] (Bioassay, Mouse)
• Xiao, T;Gong, Z;Duan, D;Yu, H;Liu, S;Jiang, Y;Xing, X;Wu, Z;Wang, L;Yang, XB;Tronci, G;Ning, C;Tan, G;Zhou, L; Injectable magnesium-bisphosphonate MOF-based bone adhesive prevents excessive fibrosis for osteoporotic fracture repair Nature communications 2025-07-01 [PMID: 40593608] (Bioassay, Mouse)
• Yang, X;Rong, K;Fu, S;Yang, Y;Liu, S;Zhang, C;Xu, K;Zhang, K;Zhu, Y;Hao, Y;Zhao, J;Fu, J; Engineered Spirulina platensis for treating rheumatoid arthritis and restoring bone homeostasis Nature communications 2025-05-13 [PMID: 40360534] (Bioassay, Mouse)
• Wei, Z;You, F;Li, H;Wu, S;Tang, F;Wan, X;Dong, H;Huang, W;Gao, S;Cai, B;Chen, X;Dong, X; Integrating network pharmacology, IPA, and molecular docking to reveal the anti-osteoporosis effects of EA and EB via the FAK pathway Frontiers in pharmacology 2025-07-02 [PMID: 40672377] (Bioassay, Mouse)
• Fukuda, Y;Shimamura, M;Etani, Y;Noguchi, T;Kurihara, T;Goshima, A;Miura, T;Hirao, M;Ochiai, N;Ju, N;Sugimoto, A;Kanamoto, T;Nakata, K;Okada, S;Ebina, K; Receptor activator of nuclear factor-kappa B ligand-derived microglia healing peptide 1-AcN inhibits osteoarthritis progression in mice Arthritis research & therapy 2025-07-09 [PMID: 40635000] (Bioassay, Mouse)
• Jantarawong, S;Khimmaktong, W;Swangphon, P;Lauterbach, N;Nanakorn, N;Panichayupakaranant, P;Pengjam, Y; Binary curcuminoid complex CRE-Bin inhibits osteoclast differentiation by suppressing the canonical NF-?B signaling pathway and modulating microRNA-223 expression Scientific reports 2025-07-01 [PMID: 40592926] (Bioassay, Mouse)
• Shi, M;Li, J;Wang, J;Yao, Y;Shen, X;Xia, Y;Xu, J; LY6E as a new prognostic biomarker of multiple myeloma-related bone disease Scientific reports 2025-04-03 [PMID: 40180998] (Bioassay, Mouse)
• Gai, D;Caviness, PC;Lazarenko, OP;Chen, JF;Randolph, CE;Zhang, Z;Cheng, Y;Sun, F;Xu, H;Blackburn, ML;Tricot, G;Shaughnessy, JD;Chen, JR;Zhan, F; Cystatin M/E Ameliorates Multiple Myeloma-Induced Hyper Osteolytic Bone Resorption Cancers 2025-02-27 [PMID: 40075680] (Bioassay, Mouse)
• Figueiredo, NC;Piacsek, M;Montalvany-Antonucci, CC;Santos, MS;Amaral, FA;Teixeira, MM;Silva, TA;Macari, S;Pandruvada, S;Andrade, I; Deletion of kinin receptor B2 enhances orthodontic tooth movement and alveolar bone remodeling PloS one 2025-02-28 [PMID: 40019931] (Bioassay, Mouse)
• Liu, Y;Shen, S;Wang, X;Chen, H;Ren, W;Wei, H;Li, K;Li, L; GATA3-Driven ceRNA Network in Lung Adenocarcinoma Bone Metastasis Progression and Therapeutic Implications Cancers 2025-02-06 [PMID: 39941924] (Bioassay, Mouse)
• Ray, S;McCall, JL;Tian, JB;Jeon, J;Douglas, A;Tyler, K;Liu, S;Berry, K;Nicewarner, B;Hall, C;Groschner, K;Bacsa, B;Geldenhuys, W;Zhu, MX;Blair, HC;Barnett, JB;Soboloff, J; Targeting TRPC channels for control of arthritis-induced bone erosion Science advances 2025-01-17 [PMID: 39813349] (Bioassay, Mouse)
• De Vos, B;Kasonga, AE;Joubert, AM;Nyakudya, TT; Exploring the In Vitro Effects of Zingerone on Differentiation and Signalling Pathways in Bone Cell Lines Metabolites 2024-12-09 [PMID: 39728474] (Bioassay, Mouse)
• Kong, X;Shan, Z;Zhao, Y;Tao, S;Chen, J;Ji, Z;Jin, J;Liu, J;Lin, W;Wang, X;Wang, J;Zhao, F;Huang, B;Chen, J; NDR2 is critical for the osteoclastogenesis by regulating ULK1-mediated mitophagy JCI insight 2024-11-19 [PMID: 39561008] (Bioassay, Mouse)
• Magnusson, C;Ransjö, M; Orthosilicic acid inhibits human osteoclast differentiation and bone resorption PloS one 2024-10-15 [PMID: 39405281] (Bioassay, Human)
• Dong, S;Ge, J;Meng, Q;Yuan, T;Wang, Y;Li, Y;Lu, Q;Song, W;Li, Z;Sun, S; Crebanine mitigates glucocorticoid-induced osteonecrosis of the femoral head by restoring bone remodelling homeostasis via attenuating oxidative stress Journal of cellular and molecular medicine 2024-08-01 [PMID: 39205463] (Bioassay, Mouse)
• Eijken, M;Krautzberger, AM;Scholze-Wittler, M;Boers-Sijmons, B;Koedam, M;Kosiol, B;Schrewe, H;van Leeuwen, JP;van der Eerden, BC; Vasorin-deficient mice display disturbed vitamin D and mineral homeostasis in combination with a low bone mass phenotype Bone reports 2024-09-01 [PMID: 39157725] (Bioassay, Mouse)
• Park, SH;Peters, M;Aguayo, C;Farris, MK;Hughes, RT;Moore, J;Munley, MT;Reno, KE;Gardin, J;Cline, JM;Peters, CM;Willey, JS; Secretory factors released from high dose radiation-activated osteoclasts increase the expression level of pain-associated neuropeptides in sensory neuronal cultures Research square 2024-07-01 [PMID: 39011106] (Bioassay, Mouse)
• Liu, Z;Wu, J;Dong, Z;Wang, Y;Wang, G;Chen, C;Wang, H;Yang, Y;Sun, Y;Yang, M;Fu, J;Li, J;Zhang, Q;Xu, Y;Pi, J; Prolonged Cadmium Exposure and Osteoclastogenesis: A Mechanistic Mouse and in Vitro Study Environmental health perspectives 2024-06-01 [PMID: 38896780] (Bioassay, Mouse, Transgenic Mouse)
• Steinacker, VC;Renner, T;Holzmeister, I;Gubik, S;Müller-Richter, U;Breitenbücher, N;Fuchs, A;Straub, A;Scheurer, M;Kübler, AC;Gbureck, U; Biological and Mechanical Performance of Dual-Setting Brushite-Silica Gel Cements Journal of functional biomaterials 2024-04-18 [PMID: 38667565] (Bioassay, Mouse)
• Li, Z;Yang, X;Fu, R;Wu, Z;Xu, S;Jiao, J;Qian, M;Zhang, L;Wu, C;Xie, T;Yao, J;Wu, Z;Li, W;Ma, G;You, Y;Chen, Y;Zhang, HK;Cheng, Y;Tang, X;Wu, P;Lian, G;Wei, H;Zhao, J;Xu, J;Ai, L;Siwko, S;Wang, Y;Ding, J;Song, G;Luo, J;Liu, M;Xiao, J; Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src Nature communications 2024-02-12 [PMID: 38346942] (Bioassay, Transgenic Mouse)
• Lima Teixeira, JF;Henning, P;Cintra Magalhães, FA;Coletto-Nunes, G;Floriano-Marcelino, T;Westerlund, A;Movérare-Skrtic, S;Oliveira, GJPL;Lerner, UH;Souza, PPC; Osteoprotective effect by interleukin-4 (IL-4) on lipoprotein-induced periodontitis Cytokine 2023-10-26 [PMID: 37898012] (Bioassay, Mouse)
• Sun, H;Wang, S;Tan, W;Li, Y;Ren, Q;Liu, Y;Huang, Y;Shi, C;Li, J; Echinococcus granulosus promotes bone resorption by increasing osteoclasts differentiation Acta tropica 2023-09-16 [PMID: 37722448] (Bioassay, Mouse)
• Chen, K;Chen, X;Lang, C;Yuan, X;Huang, J;Li, Z;Xu, M;Wu, K;Zhou, C;Li, Q;Zhu, C;Liu, L;Shang, X; CircFam190a: a critical positive regulator of osteoclast differentiation via enhancement of the AKT1/HSP90? complex Experimental & molecular medicine 2023-09-01 [PMID: 37653038] (Differentiation, Mouse)
• Kim, SY;Kim, YJ;Kim, S;Momeni, M;Lee, A;Treanor, A;Kim, S;Kim, RH;Park, NH; GV1001 Inhibits the Severity of the Ligature-Induced Periodontitis and the Vascular Lipid Deposition Associated with the Periodontitis in Mice International journal of molecular sciences 2023-08-08 [PMID: 37628753] (Bioassay, Mouse)
• Fu, J;Li, S;Ma, H;Yang, J;Pagnotti, GM;Brown, LM;Weiss, SJ;Mapara, MY;Lentzsch, S; The checkpoint inhibitor PD-1H/VISTA controls osteoclast-mediated multiple myeloma bone disease Nature communications 2023-07-17 [PMID: 37460553] (Bioassay, Mouse, Transgenic Mouse)
• Stavre, Z;Kim, JM;Yang, YS;N�ndel, K;Chaugule, S;Sato, T;Park, KH;Gao, G;Gravallese, EM;Shim, JH; Schnurri-3 inhibition suppresses bone and joint damage in models of rheumatoid arthritis Proceedings of the National Academy of Sciences of the United States of America 2023-05-09 [PMID: 37141171] (Bioassay, Mouse)
• X Ji, J Hong, W Yang, M Yao, J Wang, G Jiang, Y Wang, C Li, J Lin, H Mou, C Li, S Li, Y Chen, M Shi, W Wang, F Lu, H Wu, X Zhao, Y Qi, S Yan GSTP1-mediated S-glutathionylation of Pik3r1 is a redox hub that inhibits osteoclastogenesis through regulating autophagic flux Redox Biology, 2023-02-27;61(0):102635. 2023-02-27 [PMID: 36870110] (Bioassay, Mouse)
• H Choi, L Yang, Y Liu, JK Jeong, ES Cho Npp1 prevents external tooth root resorption by regulation of cervical cementum integrity Scientific Reports, 2022-12-07;12(1):21158. 2022-12-07 [PMID: 36477209] (Cell Culture, Mouse)
• Y Cheng, H Liu, J Li, Y Ma, C Song, Y Wang, P Li, Y Chen, Z Zhang Evaluation of culture conditions for osteoclastogenesis in RAW264.7 cells PLoS ONE, 2022-11-17;17(11):e0277871. 2022-11-17 [PMID: 36395187] (Bioassay, Mouse)
• A Duxfield, J Munkley, MD Briggs, EP Dennis CRELD2 is a novel modulator of calcium release and calcineurin-NFAT signalling during osteoclast differentiation Scientific Reports, 2022-08-16;12(1):13884. 2022-08-16 [PMID: 35974042] (Bioassay, Mouse)
• Y Zhang, M Yang, S Zhang, Z Yang, Y Zhu, Y Wang, Z Chen, X Lv, Z Huang, Y Xie, L Cai BHLHE40 promotes osteoclastogenesis and abnormal bone resorption via c-Fos/NFATc1 Cell & bioscience, 2022-05-26;12(1):70. 2022-05-26 [PMID: 35619122] (Bioassay, Mouse)
• N Imerb, C Thonusin, W Pratchayas, B Arunsak, W Nawara, B Ongnok, R Aeimlapa, N Charoenpha, N Chattipako, SC Chattipako D-galactose-induced aging aggravates obesity-induced bone dyshomeostasis Scientific Reports, 2022-05-20;12(1):8580. 2022-05-20 [PMID: 35595806] (Bioassay, Mouse)
• P Cai, S Yan, Y Lu, X Zhou, X Wang, M Wang, Z Yin Carnosol inhibits osteoclastogenesis in�vivo and in�vitro by blocking the RANKL?induced NF?kappaB signaling pathway Molecular Medicine Reports, 2022-05-20;26(1):. 2022-05-20 [PMID: 35593299] (Bioassay, Mouse)
• Z Cui, C Feng, J Chen, Y Wang, Q Meng, S Zhao, Y Zhang, D Feng, Z Li, S Sun Network Pharmacology Deciphers the Action of Bioactive Polypeptide in Attenuating Inflammatory Osteolysis via the Suppression of Oxidative Stress and Restoration of Bone Remodeling Balance Oxidative Medicine and Cellular Longevity, 2022-04-14;2022(0):4913534. 2022-04-14 [PMID: 35578727] (Bioassay, Mouse)
• Y Ma, R Di, H Zhao, R Song, H Zou, Z Liu P2X7 receptor knockdown suppresses osteoclast differentiation by inhibiting autophagy and Ca2+/calcineurin signaling Molecular Medicine Reports, 2022-03-10;25(5):. 2022-03-10 [PMID: 35266012] (Cell Culture, Mouse)
• C Yang, H Tao, H Zhang, Y Xia, J Bai, G Ge, W Li, W Zhang, L Xiao, Y Xu, Z Wang, Y Gu, H Yang, Y Liu, D Geng TET2 regulates osteoclastogenesis by modulating autophagy in OVX-induced bone loss Autophagy, 2022-03-24;0(0):. 2022-03-24 [PMID: 35255774] (Cell Culture, Mouse)
• JM Kim, YS Yang, J Xie, O Lee, J Kim, J Hong, B Boldyreff, O Filhol, H Chun, MB Greenblatt, G Gao, JH Shim Regulation of sclerostin by the SIRT1 stabilization pathway in osteocytes Cell Death and Differentiation, 2022-02-15;0(0):. 2022-02-15 [PMID: 35169297] (Bioassay, Mouse)
• ANM Mamun-Or-R, TT Lucy, M Yagi, Y Yonei Inhibitory Effects of Astaxanthin on CML-HSA-Induced Inflammatory and RANKL-Induced Osteoclastogenic Gene Expression in RAW 264.7 Cells Biomedicines, 2021-12-27;10(1):. 2021-12-27 [PMID: 35052734] (Bioassay, Mouse)
• J Gu, X Zhang, C Zhang, Y Li, J Bian, X Liu, Y Yuan, H Zou, X Tong, Z Liu Galectin-3 Contributes to the Inhibitory Effect of lalpha,25-(OH)2D3 on Osteoclastogenesis International Journal of Molecular Sciences, 2021-12-11;22(24):. 2021-12-11 [PMID: 34948130] (Bioassay, Mouse)
• S Zhou, Q Dai, X Huang, A Jin, Y Yang, X Gong, H Xu, X Gao, L Jiang STAT3 is critical for skeletal development and bone homeostasis by regulating osteogenesis Nature Communications, 2021-11-25;12(1):6891. 2021-11-25 [PMID: 34824272] (Bioassay, Mouse)
• Y Zhang, S Zhang, Y Wang, Z Yang, Z Chen, N Wen, M Yang, Z Huang, Y Xie, L Cai ULK1 Suppresses Osteoclast Differentiation and Bone Resorption via Inhibiting Syk-JNK through DOK3 Oxidative Medicine and Cellular Longevity, 2021-11-15;2021(0):2896674. 2021-11-15 [PMID: 34820053] (Bioassay, Mouse)
• Z Liu, H Wang, Y Hou, Y Yang, J Jia, J Wu, Z Zuo, T Gao, S Ren, Y Bian, S Liu, J Fu, Y Sun, J Li, M Yamamoto, Q Zhang, Y Xu, J Pi CNC-bZIP protein NFE2L1 regulates osteoclast differentiation in antioxidant-dependent and independent manners Redox Biology, 2021-11-06;48(0):102180. 2021-11-06 [PMID: 34763297] (Bioassay, Mouse)
• KH Nilsson, P Henning, ME Shahawy, M Nethander, TL Andersen, C Ejersted, J Wu, KL Gustafsson, A Koskela, J Tuukkanen, PPC Souza, J Tuckermann, M Lorentzon, LE Ruud, T Lehtimäki, JH Tobias, S Zhou, UH Lerner, JB Richards, S Movérare-S, C Ohlsson RSPO3 is important for trabecular bone and fracture risk in mice and humans Nature Communications, 2021-08-13;12(1):4923. 2021-08-13 [PMID: 34389713] (Bioassay, Mouse)
• C Fang, JW Guo, YJ Wang, XQ Li, H Zhang, J Cui, Y Hu, YY Jing, X Chen, JC Su Diterbutyl phthalate attenuates osteoarthritis in ACLT mice via suppressing ERK/c-fos/NFATc1 pathway, and subsequently inhibiting subchondral osteoclast fusion Acta pharmacologica Sinica, 2021-08-11;0(0):. 2021-08-11 [PMID: 34381182] (Bioassay, Mouse)
• K Wang, CR Donnelly, C Jiang, Y Liao, X Luo, X Tao, S Bang, A McGinnis, M Lee, MJ Hilton, RR Ji STING suppresses bone cancer pain via immune and neuronal modulation Nature Communications, 2021-07-27;12(1):4558. 2021-07-27 [PMID: 34315904] (Bioassay, Mouse)
• H Chen, G Shen, Q Shang, P Zhang, D Yu, X Yu, Z Zhang, W Zhao, Z Wu, F Tang, Liang, X Jiang, H Ren Plastrum testudinis extract suppresses osteoclast differentiation via the NF-&amp;kappaB signaling pathway and ameliorates senile osteoporosis Journal of ethnopharmacology, 2021-05-08;276(0):114195. 2021-05-08 [PMID: 33974944] (Bioassay, Mouse)
• P Xue, X Hu, E Chang, L Wang, M Chen, TH Wu, DJ Lee, BL Foster, HC Tseng, CC Ko Deficiency of optineurin enhances osteoclast differentiation by attenuating the NRF2-mediated antioxidant response Experimental & Molecular Medicine, 2021-04-16;0(0):. 2021-04-16 [PMID: 33864025] (Bioassay, Mouse)
• H Wei, Y Xu, Y Wang, L Xu, C Mo, L Li, B Shen, Y Sun, P Cheng, L Yang, Y Pang, A Qin, Y Cao, SJ Morrison, R Yue Identification of Fibroblast Activation Protein as an Osteogenic Suppressor and Anti-osteoporosis Drug Target Cell Rep, 2020-10-13;33(2):108252. 2020-10-13 [PMID: 33053358] (Bioassay, Mouse)
• Y Chen, Y Wang, R Tang, J Yang, C Dou, Y Dong, D Sun, C Zhang, L Zhang, Y Tang, Q Dai, F Luo, J Xu, S Dong Dendritic cells-derived interferon-lambda1 ameliorated inflammatory bone destruction through inhibiting osteoclastogenesis Cell Death Dis, 2020-06-02;11(6):414. 2020-06-02 [PMID: 32488049] (Bioassay, Mouse)
• K Wang, Y Gu, Y Liao, S Bang, CR Donnelly, O Chen, X Tao, AJ Mirando, MJ Hilton, RR Ji PD-1 blockade inhibits osteoclast formation and murine bone cancer pain J. Clin. Invest., 2020-07-01;0(0):. 2020-07-01 [PMID: 32484460] (Bioassay, Mouse)
• JM Kim, YS Yang, KH Park, X Ge, R Xu, N Li, M Song, H Chun, S Bok, JF Charles, O Filhol-Coc, B Boldyreff, T Dinter, PB Yu, N Kon, W Gu, T Takarada, MB Greenblatt, JH Shim A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation Nat Commun, 2020-05-08;11(1):2289. 2020-05-08 [PMID: 32385263] (Bioassay, Mouse)
• T Du, Z Yan, S Zhu, G Chen, L Wang, Z Ye, W Wang, Q Zhu, Z Lu, X Cao QKI deficiency leads to osteoporosis by promoting RANKL-induced osteoclastogenesis and disrupting bone metabolism Cell Death Dis, 2020-05-07;11(5):330. 2020-05-07 [PMID: 32382069] (Bioassay, Mouse)
• SJ Kim, YT Jeong, SR Jeong, M Park, HS Go, MY Kim, JK Seong, KW Kim, JT Seo, CH Kim, JH Lee, SJ Moon Neural regulation of energy and bone homeostasis by the synaptic adhesion molecule Calsyntenin-3 Exp. Mol. Med., 2020-05-07;0(0):. 2020-05-07 [PMID: 32382066] (Bioassay, Mouse)
• IS Kang, JS Jang, C Kim Opposing roles of hematopoietic-specific small GTPase Rac2 and the guanine nucleotide exchange factor Vav1 in osteoclast differentiation Sci Rep, 2020-04-27;10(1):7024. 2020-04-27 [PMID: 32341385] (Bioassay, Human)
• W Lei, R Duan, J Li, X Liu, A Huston, BF Boyce, Z Yao The IAP Antagonist SM-164 Eliminates Triple-Negative Breast Cancer Metastasis to Bone and Lung in Mice Sci Rep, 2020-04-24;10(1):7004. 2020-04-24 [PMID: 32332865] (Bioassay, Mouse)
• S Kiyohara, N Sakai, K Handa, T Yamakawa, K Ishikawa, M Chatani, A Karakawa, Y Azetsu, M Munakata, M Ozeki, T Negishi-Ko, M Takami Effects of N-methyl-D-aspartate receptor antagonist MK-801 (dizocilpine) on bone homeostasis in mice J Oral Biosci, 2020-04-11;0(0):. 2020-04-11 [PMID: 32289529] (Cell Culture, Mouse)
• Y Zhang, K Yang, J Yang, Y Lao, L Deng, G Deng, J Yi, X Sun, Q Wang SENP3 Suppresses Osteoclastogenesis by De-conjugating SUMO2/3 from IRF8 in Bone Marrow-Derived Monocytes Cell Rep, 2020-02-11;30(6):1951-1963.e4. 2020-02-11 [PMID: 32049023] (Bioassay, Mouse)
• JS Brunner, L Vulliard, M Hofmann, M Kieler, A Lercher, A Vogel, M Russier, JB Brüggenthi, M Kerndl, V Saferding, B Niederreit, A Junza, A Frauenstei, C Scholtysek, Y Mikami, K Klavins, G Krönke, A Bergthaler, JJ O'Shea, T Weichhart, F Meissner, JS Smolen, P Cheng, O Yanes, J Menche, PJ Murray, O Sharif, S Blüml, G Schabbauer Environmental arginine controls multinuclear giant cell metabolism and formation Nat Commun, 2020-01-22;11(1):431. 2020-01-22 [PMID: 31969567] (Cell Culture, Mouse)
• SK Pore, ER Hahm, SH Kim, KB Singh, L Nyiranshut, JD Latoche, CJ Anderson, J Adamik, DL Galson, KR Weiss, RJ Watters, B Lee, PN Kumta, SV Singh A Novel Sulforaphane-Regulated Gene Network in Suppression of Breast Cancer-Induced Osteolytic Bone Resorption Mol. Cancer Ther., 2019-11-29;0(0):. 2019-11-29 [PMID: 31784454] (Bioassay, Mouse)
• N Shang, J Wu Egg White Ovotransferrin Attenuates RANKL-Induced Osteoclastogenesis and Bone Resorption Nutrients, 2019-09-19;11(9):. 2019-09-19 [PMID: 31546863] (Bioassay, Mouse)
• L Li, AH Ameri, S Wang, KH Jansson, OM Casey, Q Yang, ML Beshiri, L Fang, RG Lake, S Agarwal, AN Alilin, W Xu, J Yin, K Kelly EGR1 regulates angiogenic and osteoclastogenic factors in prostate cancer and promotes metastasis Oncogene, 2019-07-16;0(0):. 2019-07-16 [PMID: 31312026] (Cell Culture, Mouse)
• SW Wong, BW Huang, X Hu, E Ho Kim, JP Kolb, RJ Padilla, P Xue, L Wang, TH Oguin, PA Miguez, HC Tseng, CC Ko, J Martinez Global deletion of Optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget&#039;s disease Cell Death Differ., 2019-05-10;0(0):. 2019-05-10 [PMID: 31076632] (Bioassay, Mouse)
• A Bergsma, SS Ganguly, ME Wiegand, D Dick, BO Williams, CK Miranti Regulation of cytoskeleton and adhesion signaling in osteoclasts by tetraspanin CD82 Bone Rep, 2019-01-30;10(0):100196. 2019-01-30 [PMID: 30788390] (Bioassay, Mouse)
• D Muschter, AS Beiderbeck, T Späth, C Kirschneck, A Schröder, S Grässel Sensory Neuropeptides and their Receptors Participate in Mechano-Regulation of Murine Macrophages Int J Mol Sci, 2019-01-24;20(3):. 2019-01-24 [PMID: 30682804] (Bioassay, Mouse)
• JD Jones, BP Sinder, D Paige, FN Soki, AJ Koh, S Thiele, Y Shiozawa, LC Hofbauer, S Daignault, H Roca, LK McCauley Trabectedin Reduces Skeletal Prostate Cancer Tumor Size in Association with Effects on M2 Macrophages and Efferocytosis Neoplasia, 2018-12-31;21(2):172-184. 2018-12-31 [PMID: 30591422] (Bioassay, Mouse)
• NKY Wee, BP Sinder, S Novak, X Wang, C Stoddard, BG Matthews, I Kalajzic Skeletal phenotype of the neuropeptide Y knockout mouse Neuropeptides, 2018-11-30;73(0):78-88. 2018-11-30 [PMID: 30522780] (Bioassay, Mouse)
• KM Lee, KH Park, JS Hwang, M Lee, DS Yoon, HA Ryu, HS Jung, KW Park, J Kim, SW Park, SH Kim, YM Chun, WJ Choi, JW Lee Inhibition of STAT5A promotes osteogenesis by DLX5 regulation Cell Death Dis, 2018-11-14;9(11):1136. 2018-11-14 [PMID: 30429452] (Bioassay, Mouse)
• HC Wang, P Wang, YW Chen, Y Zhang Bevacizumab or fibronectin gene editing inhibits the osteoclastogenic effects of fibroblasts derived from human radicular cysts Acta Pharmacol. Sin., 2018-10-31;0(0):. 2018-10-31 [PMID: 30382180] (Bioassay, Mouse)
• Y Mödinger, A Rapp, J Pazmandi, A Vikman, K Holzmann, M Haffner-Lu, M Huber-Lang, A Ignatius C5aR1 interacts with TLR2 in osteoblasts and stimulates the osteoclast-inducing chemokine CXCL10 J. Cell. Mol. Med., 2018-09-24;0(0):. 2018-09-24 [PMID: 30247799] (Bioassay, Mouse)
• GT Ma, SK Lee, KK Park, J Park, SH Son, M Jung, WY Chung Artemisinin-Daumone Hybrid Inhibits Cancer Cell-Mediated Osteolysis by Targeting Cancer Cells and Osteoclasts Cell. Physiol. Biochem., 2018-09-11;49(4):1460-1475. 2018-09-11 [PMID: 30205376] (Bioassay, Mouse)
• JM Ubellacker, N Baryawno, N Severe, MJ DeCristo, J Sceneay, JN Hutchinson, MT Haider, CS Rhee, Y Qin, WM Gregory, AC Garrido-Ca, I Holen, JE Brown, RE Coleman, DT Scadden, SS McAllister Modulating bone marrow hematopoietic lineage potential to prevent bone metastasis in breast cancer Cancer Res., 2018-07-31;0(0):. 2018-07-31 [PMID: 30065048] (Bioassay, Mouse)
• T Niedermair, S Schirner, R Seebröker, RH Straub, S Grässel Substance P modulates bone remodeling properties of murine osteoblasts and osteoclasts Sci Rep, 2018-06-15;8(1):9199. 2018-06-15 [PMID: 29907830] (Bioassay, Mouse)
• Z Yu, LE Surface, CY Park, MA Horlbeck, GA Wyant, M Abu-Remail, TR Peterson, DM Sabatini, JS Weissman, EK O'Shea Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing-bisphosphonates Elife, 2018-05-10;7(0):. 2018-05-10 [PMID: 29745899] (Bioassay, Mouse)
• D Gr?evi?, M Sironi, S Valentino, L Deban, H Cvija, A Inforzato, N Kova?i?, V Katavi?, T Kelava, I Kalajzi?, A Mantovani, B Bottazzi The Long Pentraxin 3 Plays a Role in Bone Turnover and Repair Front Immunol, 2018-03-05;9(0):417. 2018-03-05 [PMID: 29556234] (Bioassay, Mouse)
• T Ishii, M Ruiz-Torru, A Ikeda, S Shindo, A Movila, H Mawardi, A Albassam, RA Kayal, AA Al-Dharrab, K Egashira, W Wisitrasam, K Yamamoto, AI Mira, K Sueishi, X Han, MA Taubman, T Miyamoto, T Kawai OC-STAMP promotes osteoclast fusion for pathogenic bone resorption in periodontitis via up-regulation of permissive fusogen CD9 FASEB J., 2018-03-13;0(0):fj201701424R. 2018-03-13 [PMID: 29533736] (Bioassay, Mouse)
• ZK Jia, HY Li, YL Liang, LA Potempa, SR Ji, Y Wu Monomeric C-Reactive Protein Binds and Neutralizes Receptor Activator of NF-?B Ligand-Induced Osteoclast Differentiation Front Immunol, 2018-02-19;9(0):234. 2018-02-19 [PMID: 29520264] (Bioassay, Mouse)
• A Mediero, T Wilder, L Shah, BN Cronstein Adenosine Areceptor (A2AR) stimulation modulates expression of semaphorins 4D and 3A, regulators of bone homeostasis FASEB J., 2018-02-02;0(0):fj201700217R. 2018-02-02 [PMID: 29394106] (Differentiation, Differentiation, Mouse)
• Q Ye, G Li, S Liu, Y Guan, Y Li, J Li, H Jia, X Li, Q Li, R Huang, H Wang, Y Zhang Targeted disruption of adenosine kinase in myeloid monocyte cells increases osteoclastogenesis and bone resorption in mice Int. J. Mol. Med., 2018-01-17;0(0):. 2018-01-17 [PMID: 29344645] (Bioassay, Mouse)
• CJ Kim, SH Shin, BJ Kim, CH Kim, JH Kim, HM Kang, BS Park, IR Kim The Effects of Kaempferol-Inhibited Autophagy on Osteoclast Formation Int J Mol Sci, 2018-01-02;19(1):. 2018-01-02 [PMID: 29301320] (Bioassay, Mouse)
• D Quach, F Collins, N Parameswar, L McCabe, RA Britton Microbiota Reconstitution Does Not Cause Bone Loss in Germ-Free Mice mSphere, 2018-01-03;3(1):. 2018-01-03 [PMID: 29299532] (Bioassay, Mouse)
• HC Park, YB Son, SL Lee, GJ Rho, YH Kang, BW Park, SH Byun, SC Hwang, IA Cho, YC Cho, IY Sung, DK Woo, JH Byun Effects of Osteogenic-Conditioned Medium from Human Periosteum-Derived Cells on Osteoclast Differentiation Int J Med Sci, 2017-11-02;14(13):1389-1401. 2017-11-02 [PMID: 29200953] (Human)
• V Kram, TM Kilts, N Bhattachar, L Li, MF Young Small leucine rich proteoglycans, a novel link to osteoclastogenesis Sci Rep, 2017-10-03;7(1):12627. 2017-10-03 [PMID: 28974711] (Bioassay, Mouse)
• EL Stattin, P Henning, J Klar, E McDermott, C Stecksen-B, PE Sandström, TG Kellgren, P Rydén, G Hallmans, T Lönnerholm, A Ameur, MH Helfrich, FP Coxon, N Dahl, J Wikström, UH Lerner SNX10 gene mutation leading to osteopetrosis with dysfunctional osteoclasts Sci Rep, 2017-06-07;7(1):3012. 2017-06-07 [PMID: 28592808] (Bioassay, Human)
• F Strålberg, A Kassem, F Kasprzykow, M Abrahamson, A Grubb, C Lindholm, UH Lerner Inhibition of lipopolysaccharide-induced osteoclast formation and bone resorption in vitro and in vivo by cysteine proteinase inhibitors J. Leukoc. Biol, 2017-02-14;0(0):. 2017-02-14 [PMID: 28196851] (Bioassay, Mouse)
• Erivan S Ramos-Juni Adipokine Chemerin Bridges Metabolic Dyslipidemia and Alveolar Bone Loss in Mice J. Bone Miner. Res, 2017-03-01;0(0):. 2017-03-01 [PMID: 28029186] (Bioassay, Mouse)
• Sarit Batsir Dynamics of the sealing zone in cultured osteoclasts Cytoskeleton (Hoboken), 2017-02-08;0(0):. 2017-02-08 [PMID: 27997747] (Bioassay, Mouse)
• Tumor Cell-Derived Exosomes from the Prostate Cancer Cell Line TRAMP-C1 Impair Osteoclast Formation and Differentiation PLoS ONE, 2016-11-10;11(11):e0166284. 2016-11-10 [PMID: 27832183] (Bioassay, Mouse)
• Khor E, Fanshawe B, Qi Y, Zolotukhin S, Kulkarni R, Enriquez R, Purtell L, Lee N, Wee N, Croucher P, Campbell L, Herzog H, Baldock P Prader-Willi Critical Region, a Non-Translated, Imprinted Central Regulator of Bone Mass: Possible Role in Skeletal Abnormalities in Prader-Willi Syndrome. PLoS ONE, 2016-01-29;11(1):e0148155. 2016-01-29 [PMID: 26824232] (Bioassay, Mouse)
• Beier E, Sheu T, Dang D, Holz J, Ubayawardena R, Babij P, Puzas J Heavy Metal Ion Regulation of Gene Expression: MECHANISMS BY WHICH LEAD INHIBITS OSTEOBLASTIC BONE-FORMING ACTIVITY THROUGH MODULATION OF THE Wnt/beta-CATENIN SIGNALING PATHWAY. J Biol Chem, 2015-05-14;290(29):18216-26. 2015-05-14 [PMID: 25975268] (Bioassay, Mouse)
• Fowler T, Kamalakar A, Akel N, Kurten R, Suva L, Gaddy D Activin A inhibits RANKL-mediated osteoclast formation, movement and function in murine bone marrow macrophage cultures. J Cell Sci, 2015-01-20;128(4):683-94. 2015-01-20 [PMID: 25609708] (Bioassay, Mouse)
• Mediero A, Ramkhelawon B, Perez-Aso M, Moore K, Cronstein B Netrin-1 is a critical autocrine/paracrine factor for osteoclast differentiation. J Bone Miner Res, 2015-05-01;30(5):837-54. 2015-05-01 [PMID: 25483983] (Bioassay, Mouse)
• Abe T, Shin J, Hosur K, Udey M, Chavakis T, Hajishengallis G Regulation of osteoclast homeostasis and inflammatory bone loss by MFG-E8. J Immunol, 2014-06-23;193(3):1383-91. 2014-06-23 [PMID: 24958900] (Bioassay, Mouse)
• Schwarzer R, Nickel N, Godau J, Willie B, Duda G, Schwarzer R, Cirovic B, Leutz A, Manz R, Bogen B, Dorken B, Jundt F Notch pathway inhibition controls myeloma bone disease in the murine MOPC315.BM model. Blood Cancer J, 2014-06-13;4(0):e217. 2014-06-13 [PMID: 24927406] (Bioassay, Mouse)
• Zhang H, Hilton M, Anolik J, Welle S, Zhao C, Yao Z, Li X, Wang Z, Boyce B, Xing L NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-kappaB. J Clin Invest, 2014-06-02;124(7):3200-14. 2014-06-02 [PMID: 24892805] (Bioassay, Mouse)
• Tiwari , Meenaksh, Sharma , Lokendra, Vanegas , Difernan, Callaway , Danielle, Bai , Yidong, Lechleiter , James D, Herman , Brian A nonapoptotic role for CASP2/caspase 2: modulation of autophagy. Autophagy, 2014-06-01;10(6):1054-70. 2014-06-01 [PMID: 24879153] (Bioassay, Mouse)
• Xiu Y, Xu H, Zhao C, Li J, Morita Y, Yao Z, Xing L, Boyce B Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation. J Clin Invest, 2013-12-09;124(1):297-310. 2013-12-09 [PMID: 24316970] (Bioassay, Mouse)
• Stalvey M, Clines K, Havasi V, McKibbin C, Dunn L, Chung W, Clines G Osteoblast CFTR inactivation reduces differentiation and osteoprotegerin expression in a mouse model of cystic fibrosis-related bone disease. PLoS ONE, 2013-11-13;8(11):e80098. 2013-11-13 [PMID: 24236172] (Bioassay, Mouse)
• Sun Q, Sammut B, Wang F, Kurihara N, Windle J, Roodman G, Galson D TBK1 mediates critical effects of measles virus nucleocapsid protein (MVNP) on pagetic osteoclast formation. J Bone Miner Res, 2014-01-01;29(1):90-102. 2014-01-01 [PMID: 23794264] (Bioassay, Mouse)
• Muruganandan S, Dranse H, Rourke J, McMullen N, Sinal C Chemerin neutralization blocks hematopoietic stem cell osteoclastogenesis. Stem Cells, 2013-10-01;31(10):2172-82. 2013-10-01 [PMID: 23766088] (Bioassay, Mouse)
• Fujiwara T, Fukushi J, Yamamoto S, Matsumoto Y, Setsu N, Oda Y, Yamada H, Okada S, Watari K, Ono M, Kuwano M, Kamura S, Iida K, Okada Y, Koga M, Iwamoto Y Macrophage infiltration predicts a poor prognosis for human ewing sarcoma. Am. J. Pathol., 2011-07-21;179(3):1157-70. 2011-07-21 [PMID: 21771572] (Bioassay, Mouse)
• Kulkarni RN, Bakker AD, Everts V, Klein-Nulend J Inhibition of osteoclastogenesis by mechanically loaded osteocytes: involvement of MEPE. Calcif. Tissue Int., 2010-08-20;87(5):461-8. 2010-08-20 [PMID: 20725825] (Bioassay, Mouse)
• Binder NB, Niederreiter B, Hoffmann O, Stange R, Pap T, Stulnig TM, Mack M, Erben RG, Smolen JS, Redlich K Estrogen-dependent and C-C chemokine receptor-2-dependent pathways determine osteoclast behavior in osteoporosis. Nat. Med., 2009-03-29;15(4):417-24. 2009-03-29 [PMID: 19330010] (Bioassay, Flow Cytometry, Mouse)
• Johansson MK, de Vries TJ, Schoenmaker T, Ehinger M, Brun AC, Fasth A, Karlsson S, Everts V, Richter J Hematopoietic stem cell-targeted neonatal gene therapy reverses lethally progressive osteopetrosis in oc/oc mice. Blood, 2007-03-01;109(12):5178-85. 2007-03-01 [PMID: 17332244] (Bioassay, Mouse)
• de Vries TJ, Schoenmaker T, Wattanaroonwong N, van den Hoonaard M, Nieuwenhuijse A, Beertsen W, Everts V Gingival fibroblasts are better at inhibiting osteoclast formation than periodontal ligament fibroblasts. J. Cell. Biochem., 2006-05-15;98(2):370-82. 2006-05-15 [PMID: 16440316] (Bioassay, Mouse)
• Liao TS, Yurgelun MB, Chang SS, Zhang HZ, Murakami K, Blaine TA, Parisien MV, Kim W, Winchester RJ, Lee FY Recruitment of osteoclast precursors by stromal cell derived factor-1 (SDF-1) in giant cell tumor of bone. J. Orthop. Res., 2005-01-01;23(1):203-9. 2005-01-01 [PMID: 15607894] (Bioassay, Mouse)

Bioinformatics

• Gene Symbol: Tnfsf11
• Uniprot:
  • Q3TWY5()