Recombinant Mouse P-Selectin/CD62P Fc Chimera Protein, CF


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Recombinant Mouse P-Selectin/CD62P Fc Chimera Protein, CF Summary

Details of Functionality
Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells. P-Selectin/Fc Chimera immobilized at 10 µg/mL will induce greater than 50% adhesion on U937 cells.
Optimal dilutions should be determined be each laboratory for each application.
Mouse myeloma cell line, NS0-derived mouse P-Selectin/CD62P protein
Mouse P-Selectin
Accession # Q01102
N-terminus C-terminus
Accession #
N-terminal Sequence
Structure / Form
Disulfide-linked homodimer
Protein/Peptide Type
Recombinant Proteins
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Note
<1.0 EU per 1 μg of the protein by the LAL method.


Theoretical MW
99.1 kDa (monomer).
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
127-140 kDa, reducing conditions
Read Publications using
737-PS in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS.
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Reconstitution Instructions
Reconstitute at 100 μg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse P-Selectin/CD62P Fc Chimera Protein, CF

  • CD62P antigen
  • CD62P
  • FLJ45155
  • GMP140
  • GRMP
  • PADGEMantigen CD62)
  • PSEL
  • P-Selectin
  • selectin P (granule membrane protein 140kDa, antigen CD62)
  • SELP


Mouse P-Selectin (GMP-140, LECAM-3, PADGEM, CD62P), a member of the Selectin family, is a cell surface glycoprotein expressed by activated platelets and endothelial cells. P-Selectin is translocated to the cell surface within minutes, from alpha granules of platelets or Weibel-Palade bodies of endothelial cells, following stimulation with thrombin, histamine, PMA or peroxides. P-Selectin binds to a 106 kDa protein present on myeloid cells, neutrophils, monocytes and lymphocytes, termed PSGL-1 (P-Selectin glycoprotein ligand-1).

P-Selectin plays a role in the adhesion of leukocytes and neutrophils to the endothelium. Acting in cooperation with L-Selectin, P-Selectin mediates the initial interaction of circulating leukocytes with endothelial cells that produces a characteristic ‘rolling’ of the leukocytes on the endothelium. This initial interaction is followed by a stronger interaction involving E-Selectin, and later ICAM-1 and VCAM-1, that leads eventually to extravasation of the white blood cell through the blood vessel wall into the extracellular matrix tissue.

Mouse P-Selectin cDNA encodes a 768 amino acid (aa) residue type I transmembrane protein with a 41 aa signal peptide, a 668 aa extracellular domain, a transmembrane domain and a short (35 aa) cytoplasmic domain. The extracellular domain has an NH2-terminal C-type lectin domain and an EGF-like domain followed by a series of complement factor A repeat homology domains. The extracellular domains of human and mouse P-Selectin share approximately 73% sequence homology.

  1. Kansas, G.S. (1996) Blood 88:3259.
  2. McEver, R.P. and R.D. Cummings (1997) J. Clin. Invest. 100:485.

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Publications for P-Selectin/CD62P (737-PS)(23)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 5 applications: Adhesion Assay, Binding Assay, Bioassay, Flow Cytometry, In Vivo.

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Showing Publications 1 - 10 of 23. Show All 23 Publications.
Publications using 737-PS Applications Species
V Barbier, J Erbani, C Fiveash, JM Davies, J Tay, MR Tallack, J Lowe, JL Magnani, DR Pattabiram, AC Perkins, J Lisle, JEJ Rasko, JP Levesque, IG Winkler Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance Nat Commun, 2020;11(1):2042. 2020 [PMID: 32341362] (Bioassay, Mouse) Bioassay Mouse
SJ Hobbs, JC Nolz Targeted Expansion of Tissue-Resident CD8+ T Cells to Boost Cellular Immunity in the Skin Cell Rep, 2019;29(10):2990-2997.e2. 2019 [PMID: 31801067] (Flow Cytometry, Mouse) Flow Cytometry Mouse
FA Moretti, S Klapproth, R Ruppert, A Margraf, J Weber, R Pick, C Scheierman, M Sperandio, R Fässler, M Moser Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus Elife, 2018;7(0):. 2018 [PMID: 30187863]
Y Pan, T Tian, CO Park, SY Lofftus, S Mei, X Liu, C Luo, JT O'Malley, A Gehad, JE Teague, SJ Divito, R Fuhlbrigge, P Puigserver, JG Krueger, GS Hotamislig, RA Clark, TS Kupper Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism Nature, 2017;0(0):. 2017 [PMID: 28219080] (Bioassay, Human) Bioassay Human
X Jiang, CO Park, J Geddes Swe, MJ Yoo, O Gaide, TS Kupper Dermal ?� T Cells Do Not Freely Re-Circulate Out of Skin and Produce IL-17 to Promote Neutrophil Infiltration during Primary Contact Hypersensitivity PLoS ONE, 2017;12(1):e0169397. 2017 [PMID: 28081153] (Flow Cytometry, Mouse) Flow Cytometry Mouse
Sepsis-induced thymic atrophy is associated with defects in early lymphopoiesis Stem Cells, 2016;0(0):. 2016 [PMID: 27422171] (Bioassay, Mouse) Bioassay Mouse
Platelets Guide Leukocytes to Their Sites of Extravasation PLoS Biol, 2016;14(5):e1002459. 2016 [PMID: 27152726] (Bioassay, Mouse) Bioassay Mouse
Velazquez F, Grodecki-Pena A, Knapp A, Salvador A, Nevers T, Croce K, Alcaide P CD43 Functions as an E-Selectin Ligand for Th17 Cells In Vitro and Is Required for Rolling on the Vascular Endothelium and Th17 Cell Recruitment during Inflammation In Vivo. J Immunol, 2016;196(3):1305-16. 2016 [PMID: 26700769] (Bioassay, Mouse) Bioassay Mouse
Nussbaum C, Bannenberg S, Keul P, Graler M, Goncalves-de-Albuquerque C, Korhonen H, von Wnuck Lipinski K, Heusch G, de Castro Faria Neto H, Rohwedder I, Gothert J, Prasad V, Haufe G, Lange-Sperandio B, Offermanns S, Sperandio M, Levkau B Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin. Nat Commun, 2015;6(0):6416. 2015 [PMID: 25832730] (Bioassay, Mouse) Bioassay Mouse
Krishnamurthy V, Sardar M, Ying Y, Song X, Haller C, Dai E, Wang X, Hanjaya-Putra D, Sun L, Morikis V, Simon S, Woods R, Cummings R, Chaikof E Glycopeptide analogues of PSGL-1 inhibit P-selectin in vitro and in vivo. Nat Commun, 2015;6(0):6387. 2015 [PMID: 25824568] (Bioassay, Mouse) Bioassay Mouse
Show All 23 Publications.

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Gene Symbol Selp