Recombinant Mouse IL-13 Protein, CF

Recombinant Mouse IL-13 (Catalog # 413‑ML/CF) stimulates cell proliferation of the TF-1 human erythroleukemic cell line. The ED50 for this effect is 0.75-3 ng/mL.

1 μg/lane of Recombinant Mouse IL-13 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 9 kDa.

• Reactivity: Mu
• Applications: Bioactivity
• Format: Carrier-Free

Recombinant Mouse IL-13 Protein, CF Summary

• Additional Information: Earn double rewards for reviews
• Details of Functionality: Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. Kitamura, T. et al. (1989) J. Cell Physiol. 140:323. The ED₅₀ for this effect is 0.75‑3 ng/mL.
• Source: E. coli-derived mouse IL-13 protein
  Ser26-Phe131
• Accession #: P20109
• N-terminal Sequence: Ser26
• Protein/Peptide Type: Recombinant Proteins
• Gene: Il13
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Endotoxin Note: <0.01 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 11.5 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• SDS-PAGE: 9 kDa, reducing conditions

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS.
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution Instructions: Reconstitute 5 µg vials at 50 µg/mL in sterile PBS. Reconstitute 25 µg or larger vials at 100 µg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse IL-13 Protein, CF

• ALRHMGC116789
• BHR1interleukin-13
• IL13
• IL-13
• IL-13MGC116788
• interleukin 13
• MGC116786
• NC30
• P600

Background

IL-13 is a 17 kDa immunoregulatory cytokine that plays a key role in the pathogenesis of allergic asthma and atopy. It is secreted by Th1 and Th2 CD4⁺ T cells, NK cells, visceral smooth muscle cells, eosinophils, mast cells, and basophils (1 - 3). IL-13 circulates as a monomer with two internal disulfide bonds that contribute to a bundled four alpha -helix configuration (4, 5). Mature mouse IL-13 shares 57%, 75%, and 58% amino acid sequence identity with human, rat, and rhesus IL-13, respectively. Despite the low homology, it exhibits cross-species activity between human, mouse, and rat (6, 7). IL-13 has diverse activities on numerous cell types (8). On macrophages, IL-13 suppresses the production of proinflammatory cytokines and other cytotoxic substances. On B cells, IL-13 induces immunoglobulin class switching to IgE, upregulates the expression of MHC class II, CD71, CD72, and CD23, and costimulates proliferation. IL-13 upregulates IL-6 while downregulating IL-1 and TNF-alpha production by fibroblasts and endothelial cells. IL-13 binds with low affinity to IL-13 R alpha 1, triggering IL-13 R alpha 1 association with IL-4 R alpha . This high affinity receptor complex also functions as the type 2 IL-4 receptor complex (9, 10). Additionally, IL-13 binds with high affinity to IL-13 R alpha 2 which is expressed intracellularly, on the cell surface, and as a soluble molecule (11 - 14). IL-13 R alpha 2 regulates the bioavailability of both IL-13 and IL-4 and is overexpressed in glioma and several bronchial pathologies (10, 15, 16). Compared to wild type IL-13, the atopy-associated R110Q variant of IL-13 elicits increased responsiveness from eosinophils that express low levels of IL-13 R alpha 2 (17).

1. Wills-Karp, M. (2004) Immunol. Rev. 202:175.
2. Nakajima, H. and K. Takatsu (2007) Int. Arch. Allergy Immunol. 142:265.
3. Brown, K.D. et al. (1989) J. Immunol. 142:679.
4. Moy, F.J. et al. (2001) J. Mol. Biol. 310:219.
5. Eisenmesser, E.Z. et al. (2001) J. Mol. Biol. 310:231.
6. Ruetten, H. and C. Thiemermann (1997) Shock 8:409.
7. Lakkis, F.G. et al. (1997) Biochem. Biophys. Res. Commun. 235:529.
8. Wynn, T.A. (2003) Annu. Rev. Immunol. 21:425.
9. Andrews, A.L. et al. (2002) J. Biol. Chem. 277:46073.
10. Tabata, Y. et al. (2007) Curr. Allergy Asthma Rep. 7:338.
11. Chiaramonte, M.G. et al. (2003) J. Exp. Med. 197:687.
12. Daines, M.O. and G.K. Hershey (2002) J. Biol. Chem. 227:10387.
13. Matsumura, M. et al. (2007) Biochem. Biophys. Res. Commun. 360:464.
14. Tabata, Y. et al. (2007) J. Immunol. 177:7905.
15. Andrews, A.L. et al. (2006) J. Allergy Clin. Immunol. 118:858.
16. Joshi, B.H. et al. (2006) Vitam. Horm. 74:479.
17. Andrews, A.-L. et al. (2007) J. Allergy Clin. Immunol. 120:91.

Publications for IL-13 (413-ML/CF)(86)

Publications using 413-ML/CF

• N Beckmann, A Neuhaus, S Zurbruegg, P Volkmer, C Patino, S Joller, D Feuerbach, A Doelemeyer, T Schweizer, S Rudin, U Neumann, R Berth, W Frieauff, F Gasparini, DR Shimshek Genetic models of cleavage-reduced and soluble TREM2 reveal distinct effects on myelination and microglia function in the cuprizone model Journal of Neuroinflammation, 2023-02-08;20(1):29. 2023-02-08 [PMID: 36755323] (Bioassay, Mouse)
• RK Gurram, D Wei, Q Yu, MJ Butcher, X Chen, K Cui, G Hu, M Zheng, X Zhu, J Oh, B Sun, JF Urban, K Zhao, WJ Leonard, J Zhu Crosstalk between ILC2s and Th2 cells varies among mouse models Cell Reports, 2023-02-02;42(2):112073. 2023-02-02 [PMID: 36735533] (Bioassay, Human)
• A Mironov, M Fisher, P Narayanan, R Elsayed, M Karabuluto, N Akhtar Rac1 controls cell turnover and reversibility of the involution process in postpartum mammary glands PloS Biology, 2023-01-19;21(1):e3001583. 2023-01-19 [PMID: 36656812] (Bioassay, Mouse)
• MMA de Almeida, AES Watson, S Bibi, NL Dittmann, K Goodkey, P Sharafodin, D Galleguill, M Nakhaei-Ne, J Kosaraju, N Steinberg, BS Wang, T Footz, F Giuliani, J Wang, S Sipione, JM Edgar, A Voronova Fractalkine enhances oligodendrocyte regeneration and remyelination in a demyelination mouse model Stem Cell Reports, 2023-01-05;0(0):. 2023-01-05 [PMID: 36608690] (Bioassay, Mouse)
• H Cho, HY Kwon, A Sharma, SH Lee, X Liu, N Miyamoto, JJ Kim, SH Im, NY Kang, YT Chang Visualizing inflammation with an M1 macrophage selective probe via GLUT1 as the gating target Nature Communications, 2022-10-10;13(1):5974. 2022-10-10 [PMID: 36216803] (Bioassay, Mouse)
• Y Inoue, CW Liao, Y Tsunakawa, IL Tsai, S Takahashi, M Hamada Macrophage-Specific, Mafb-Deficient Mice Showed Delayed Skin Wound Healing International Journal of Molecular Sciences, 2022-08-19;23(16):. 2022-08-19 [PMID: 36012611] (Cell Culture, Mouse)
• R Guo, X Jia, Z Ding, G Wang, M Jiang, B Li, S Chen, B Xia, Q Zhang, J Liu, R Zheng, Z Gao, X Xie Loss of MLKL ameliorates liver fibrosis by inhibiting hepatocyte necroptosis and hepatic stellate cell activation Theranostics, 2022-07-04;12(11):5220-5236. 2022-07-04 [PMID: 35836819] (Bioassay, Mouse)
• MK Ameka, WN Beavers, CM Shaver, LB Ware, VE Kerchberge, KQ Schoenfelt, L Sun, T Koyama, EP Skaar, L Becker, AH Hasty An Iron Refractory Phenotype in Obese Adipose Tissue Macrophages Leads to Adipocyte Iron Overload International Journal of Molecular Sciences, 2022-07-03;23(13):. 2022-07-03 [PMID: 35806422] (Bioassay, Mouse)
• AP Leinroth, AJ Mirando, D Rouse, Y Kobayahsi, PR Tata, HE Rueckert, Y Liao, JT Long, JV Chakkalaka, MJ Hilton Identification of distinct non-myogenic skeletal-muscle-resident mesenchymal cell populations Cell Reports, 2022-05-10;39(6):110785. 2022-05-10 [PMID: 35545045] (Bioassay, Mouse)
• X Xiao, Y Li, Y Wang, Y Zhang, J Chen, W Liu, J Tang, F Yue, J Yang Dihydroartemisinin inhibits Lewis Lung carcinoma progression by inducing macrophages M1 polarization via AKT/mTOR pathway International immunopharmacology, 2021-12-15;103(0):108427. 2021-12-15 [PMID: 34922249] (Polarization, Mouse)
• RD Hu, W Zhang, L Li, ZQ Zuo, M Ma, JF Ma, TT Yin, CY Gao, SH Yang, ZB Zhao, ZJ Li, GB Qiao, ZX Lian, K Qu Chromatin accessibility analysis identifies the transcription factor ETV5 as a suppressor of adipose tissue macrophage activation in obesity Cell Death & Disease, 2021-10-29;12(11):1023. 2021-10-29 [PMID: 34716308] (Bioassay, Mouse)
• CN Noto, SG Hoft, KA Bockerstet, NM Jackson, EL Ford, LS Vest, RJ DiPaolo IL-13 acts directly on gastric epithelial cells to promote metaplasia development during chronic gastritis Cellular and Molecular Gastroenterology and Hepatology, 2021-09-26;0(0):. 2021-09-26 [PMID: 34587523] (Bioassay, Mouse)
• M Qadri, GD Jay, LX Zhang, TA Schmidt, J Totonchy, KA Elsaid Proteoglycan-4 is an essential regulator of synovial macrophage polarization and inflammatory macrophage joint infiltration Arthritis Research & Therapy, 2021-09-14;23(1):241. 2021-09-14 [PMID: 34521469] (Bioassay, Mouse)
• AE Engler, AB Ysasi, RMF Pihl, C Villacorta, HM Heston, HMK Richardson, BR Thapa, NR Moniz, AC Belkina, SA Mazzilli, JR Rock Airway-Associated Macrophages in Homeostasis and Repair Cell Reports, 2020-12-29;33(13):108553. 2020-12-29 [PMID: 33378665] (Bioassay, Transgenic Mouse)
• JPM Luiz, JE Toller-Kaw, PR Viacava, DC Nascimento, PT Pereira, AL Saraiva, DS Prado, M LeBert, E Giurisato, C Tournier, TM Cunha, FQ Cunha, V Quesniaux, B Ryffel, JC Alves-Filh MEK5/ERK5 signaling mediates IL-4-induced M2 macrophage differentiation through regulation of c-Myc expression J. Leukoc. Biol., 2020-08-03;0(0):. 2020-08-03 [PMID: 32745297] (Bioassay, Mouse)
• P Raju, N Shashikant, PY Tsai, P Pongkorpsa, S Chanez-Par, PR Steinhagen, WT Kuo, G Singh, S Tsukita, JR Turner Inactivation of paracellular cation-selective claudin-2 channels attenuates immune-mediated experimental colitis in mice J. Clin. Invest., 2020-10-01;0(0):. 2020-10-01 [PMID: 32516134] (Bioassay, Mouse)
• V Delprat, C Tellier, C Demazy, M Raes, O Feron, C Michiels Cycling hypoxia promotes a pro-inflammatory phenotype in macrophages via JNK/p65 signaling pathway Sci Rep, 2020-01-21;10(1):882. 2020-01-21 [PMID: 31964911] (Bioassay, Mouse)
• PAM Cavalcante, N Alenina, A Budu, LC Freitas-Li, T Alves-Silv, JSH Agudelo, F Qadri, NOS Camara, M Bader, RC Araújo Nephropathy in Hypertensive Animals Is Linked to M2 Macrophages and Increased Expression of the YM1/Chi3l3 Protein Mediators Inflamm., 2019-07-10;2019(0):9086758. 2019-07-10 [PMID: 31360120] (Cell Culture, Mouse)
• CP Hans, N Sharma, S Sen, S Zeng, R Dev, Y Jiang, A Mahajan, T Joshi Transcriptomics Analysis Reveals New Insights into the Roles of Notch1 Signaling on Macrophage Polarization Sci Rep, 2019-05-29;9(1):7999. 2019-05-29 [PMID: 31142802] (Bioassay, Mouse)
• K Paduch, A Debus, B Rai, U Schleicher, C Bogdan Resolution of Cutaneous Leishmaniasis and Persistence of Leishmania major in the Absence of Arginase 1 J. Immunol., 2019-01-21;0(0):. 2019-01-21 [PMID: 30665936] (Bioassay, Mouse)
• W Fonseca, AJ Rasky, C Ptaschinsk, SH Morris, SKK Best, M Phillips, CA Malinczak, NW Lukacs Group 2 innate lymphoid cells (ILC2) are regulated by stem cell factor during chronic asthmatic disease Mucosal Immunol, 2019-01-07;12(2):445-456. 2019-01-07 [PMID: 30617299] (Bioassay, Mouse)
• R Sugamata, A Donko, Y Murakami, HE Boudreau, CF Qi, J Kwon, TL Leto Duox1 Regulates Primary B Cell Function under the Influence of IL-4 through BCR-Mediated Generation of Hydrogen Peroxide J. Immunol., 2018-12-17;0(0):. 2018-12-17 [PMID: 30559322] (Bioassay, Mouse)
• C Farruggia, MB Kim, M Bae, Y Lee, TX Pham, Y Yang, MJ Han, YK Park, JY Lee Astaxanthin exerts anti-inflammatory and antioxidant effects in macrophages in NRF2-dependent and independent manners J. Nutr. Biochem., 2018-09-19;62(0):202-209. 2018-09-19 [PMID: 30308382] (Bioassay, Mouse)
• N Chia, RK Kumar, PS Foster, C Herbert Enhanced Pro-Inflammatory Response of Macrophages to Interleukin-33 in an Allergic Environment Int. Arch. Allergy Immunol., 2018-04-05;0(0):. 2018-04-05 [PMID: 29621782] (Bioassay, Mouse)
• T Kobori, S Hamasaki, A Kitaura, Y Yamazaki, T Nishinaka, A Niwa, S Nakao, H Wake, S Mori, T Yoshino, M Nishibori, H Takahashi Interleukin-18 Amplifies Macrophage Polarization and Morphological Alteration, Leading to Excessive Angiogenesis Front Immunol, 2018-03-06;9(0):334. 2018-03-06 [PMID: 29559970] (Bioassay, Mouse)
• Y Kasagi, PM Chandramou, KA Whelan, K Tanaka, V Giroux, M Sharma, J Wang, AJ Benitez, M DeMarshall, JW Tobias, KE Hamilton, GW Falk, JM Spergel, AJ Klein-Szan, AK Rustgi, AB Muir, H Nakagawa The Esophageal Organoid System Reveals Functional Interplay Between Notch and Cytokines in Reactive Epithelial�Changes Cell Mol Gastroenterol Hepatol, 2018-01-03;5(3):333-352. 2018-01-03 [PMID: 29552622] (Bioassay, Mouse)
• L Li, S Zhang, X Jiang, Y Liu, K Liu, C Yang MicroRNA-let-7e regulates the progression and development of allergic rhinitis by targeting suppressor of cytokine signaling 4 and activating Janus kinase 1/signal transducer and activator of transcription 3 pathway Exp Ther Med, 2018-02-01;15(4):3523-3529. 2018-02-01 [PMID: 29545878] (Bioassay, Mouse)
• A Das, CS Yang, S Arifuzzama, S Kim, SY Kim, KH Jung, YS Lee, YG Chai High-Resolution Mapping and Dynamics of the Transcriptome, Transcription Factors, and Transcription Co-Factor Networks in Classically and Alternatively Activated Macrophages Front Immunol, 2018-01-18;9(0):22. 2018-01-18 [PMID: 29403501] (Cell Culture, Mouse)
• Y Ito, N Schaefer, A Sanchez, D Francisco, R Alam, RJ Martin, JG Ledford, C Stevenson, D Jiang, L Li, M Kraft, HW Chu Toll-Interacting Protein, Tollip, Inhibits IL-13-Mediated Pulmonary Eosinophilic Inflammation in Mice J Innate Immun, 2018-01-27;0(0):. 2018-01-27 [PMID: 29393212] (Bioassay, In Vivo, Mouse)
• S Wan, X Sun, F Wu, Z Yu, L Wang, D Lin, Z Li, Z Wu, X Sun Chi3l3: a potential key orchestrator of eosinophil recruitment in meningitis induced by Angiostrongylus cantonensis J Neuroinflammation, 2018-02-02;15(1):31. 2018-02-02 [PMID: 29391024] (Bioassay, Mouse)
• H Yang, Y Chen, C Gao Interleukin-13 reduces cardiac injury and prevents heart dysfunction in viral myocarditis via enhanced M2 macrophage polarization Oncotarget, 2017-08-10;8(59):99495-99503. 2017-08-10 [PMID: 29245918] (Bioassay, In Vivo, Mouse)
• T Kerrinnes, MG Winter, BM Young, VE Diaz-Ochoa, SE Winter, RM Tsolis Utilization of host polyamines in alternatively activated macrophages promotes chronic infection by Brucella abortus Infect. Immun., 2018-02-20;0(0):. 2018-02-20 [PMID: 29203548] (Bioassay, Mouse)
• R Bruen, S Curley, S Kajani, D Crean, ME O'Reilly, MB Lucitt, CG Godson, FC McGillicud, O Belton Liraglutide dictates macrophage phenotype in apolipoprotein E null mice during early atherosclerosis Cardiovasc Diabetol, 2017-11-06;16(1):143. 2017-11-06 [PMID: 29110715] (Bioassay, Mouse)
• A Nasti, Y Sakai, A Seki, GB Buffa, T Komura, H Mochida, M Yamato, K Yoshida, TTB Ho, M Takamura, S Usui, T Wada, M Honda, S Kaneko The CD45(+) fraction in murine adipose tissue-derived stromal cells harbor immune-inhibitory inflammatory cells Eur. J. Immunol., 2017-09-26;0(0):. 2017-09-26 [PMID: 28891216] (Bioassay, Mouse)
• CA Sorgi, S Zarini, SA Martin, RL Sanchez, RF Scandiuzzi, MA Gijón, C Guijas, N Flamand, RC Murphy, LH Faccioli Dormant 5-lipoxygenase in inflammatory macrophages is triggered by exogenous arachidonic acid Sci Rep, 2017-09-08;7(1):10981. 2017-09-08 [PMID: 28887514] (Bioassay, Mouse)
• AS Morris, SC Sebag, JD Paschke, A Wongrakpan, K Ebeid, ME Anderson, IM Grumbach, AK Salem Cationic CaMKII Inhibiting Nanoparticles Prevent Allergic Asthma Mol. Pharm., 2017-05-09;0(0):. 2017-05-09 [PMID: 28460526] (Bioassay, Mouse)
• T Sezaki, Y Hirata, T Hagiwara, YI Kawamura, T Okamura, R Takanashi, K Nakano, M Tamura-Nak, LC Burkly, T Dohi Disruption of the TWEAK/Fn14 pathway prevents 5-fluorouracil-induced diarrhea in mice World J. Gastroenterol., 2017-04-07;23(13):2294-2307. 2017-04-07 [PMID: 28428709] (Bioassay, Mouse)
• DC Nascimento, PH Melo, AR Piñeros, RG Ferreira, DF Colón, PB Donate, FV Castanheir, A Gozzi, PG Czaikoski, W Niedbala, MC Borges, DS Zamboni, FY Liew, FQ Cunha, JC Alves-Filh IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population Nat Commun, 2017-04-04;8(0):14919. 2017-04-04 [PMID: 28374774] (Bioassay, Mouse)
• T Eddens, W Elsegeiny, ML Garcia-Her, P Castillo, G Trevejo-Nu, K Serody, BT Campfield, SA Khader, K Chen, J Rangel-Mor, JK Kolls Pneumocystis-Driven Inducible Bronchus-Associated Lymphoid Tissue Formation Requires Th2 and Th17 Immunity Cell Rep, 2017-03-28;18(13):3078-3090. 2017-03-28 [PMID: 28355561] (In Vivo, Mouse)
• W Dawicki, C Li, J Town, X Zhang, JR Gordon Therapeutic reversal of food allergen sensitivity by mature retinoic acid-differentiated dendritic cell induction of LAG3(+)CD49b(-)Foxp3(-) regulatory T�cells J. Allergy Clin. Immunol., 2016-10-26;139(5):1608-1620.e3. 2016-10-26 [PMID: 28277274] (ELISA (Standard), Mouse)
• N Ng Kuet Le, F Brombacher, AH Dalpke, M Weitnauer Crosstalk between glucocorticoids and IL-4 modulates Ym1 expression in alternatively activated myeloid cells Immunobiology, 2017-02-09;0(0):. 2017-02-09 [PMID: 28209270] (Bioassay, Mouse)
• SC Sebag, OM Koval, JD Paschke, CJ Winters, OA Jaffer, R Dworski, FS Sutterwala, ME Anderson, IM Grumbach Mitochondrial CaMKII inhibition in airway epithelium protects against allergic asthma JCI Insight, 2017-02-09;2(3):e88297. 2017-02-09 [PMID: 28194433] (Bioassay, Mouse)
• Identification and Function of Fibrocytes in Skeletal Muscle Injury Repair and Muscular Dystrophy J. Immunol., 2016-11-09;197(12):4750-4761. 2016-11-09 [PMID: 27913649] (Bioassay, Human)
• Roles of endoplasmic reticulum stress-mediated apoptosis in M1-polarized macrophages during mycobacterial infections Sci Rep, 2016-11-15;6(0):37211. 2016-11-15 [PMID: 27845414] (Bioassay, Mouse)
• Niels Olsen Saraiva Camara Early infiltration of p40IL12(+)CCR7(+)CD11b(+) cells is critical for fibrosis development Immun Inflamm Dis, 2016-07-21;4(3):300-14. 2016-07-21 [PMID: 27621813] (Bioassay, Mouse)
• IL4RA on lymphatic endothelial cells promotes T cell egress during sclerodermatous graft versus host disease JCI Insight, 2016-08-04;1(12):. 2016-08-04 [PMID: 27547823] (Bioassay, Mouse)
• Wu K, Byers D, Jin X, Agapov E, Alexander-Brett J, Patel A, Cella M, Gilfilan S, Colonna M, Kober D, Brett T, Holtzman M TREM-2 promotes macrophage survival and lung disease after respiratory viral infection. J Exp Med, 2015-04-20;212(5):681-97. 2015-04-20 [PMID: 25897174] (Bioassay, Mouse)
• Liu K, Zhao E, Ilyas G, Lalazar G, Lin Y, Haseeb M, Tanaka K, Czaja M Impaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization. Autophagy, 2015-01-01;11(2):271-84. 2015-01-01 [PMID: 25650776] (Bioassay, Mouse)
• Ballinger M, Newstead M, Zeng X, Bhan U, Mo X, Kunkel S, Moore B, Flavell R, Christman J, Standiford T IRAK-M promotes alternative macrophage activation and fibroproliferation in bleomycin-induced lung injury. J Immunol, 2015-01-16;194(4):1894-904. 2015-01-16 [PMID: 25595781] (Bioassay, Mouse)
• Sahin E, Haubenwallner S, Kuttke M, Kollmann I, Halfmann A, Dohnal A, Chen L, Cheng P, Hoesel B, Einwallner E, Brunner J, Kral J, Schrottmaier W, Thell K, Saferding V, Bluml S, Schabbauer G Macrophage PTEN regulates expression and secretion of arginase I modulating innate and adaptive immune responses. J Immunol, 2014-07-11;193(4):1717-27. 2014-07-11 [PMID: 25015834] (Bioassay, Mouse)
• Stouch A, Zaynagetdinov R, Barham W, Stinnett A, Slaughter J, Yull F, Hoffman H, Blackwell T, Prince L IkappaB kinase activity drives fetal lung macrophage maturation along a non-M1/M2 paradigm. J Immunol, 2014-06-30;193(3):1184-93. 2014-06-30 [PMID: 24981452] (Bioassay, Mouse)
• Shibata T, Habiel D, Coelho A, Kunkel S, Lukacs N, Hogaboam C Axl receptor blockade ameliorates pulmonary pathology resulting from primary viral infection and viral exacerbation of asthma. J Immunol, 2014-03-21;192(8):3569-81. 2014-03-21 [PMID: 24659691] (ELISA (Standard), Mouse)
• Hiroshima Y, Hsu K, Tedla N, Chung Y, Chow S, Herbert C, Geczy C S100A8 induces IL-10 and protects against acute lung injury. J Immunol, 2014-02-14;192(6):2800-11. 2014-02-14 [PMID: 24532576] (Bioassay, Mouse)
• Veremeyko , Tatyana, Siddiqui , Shafiudd, Sotnikov , Ilya, Yung , Amanda, Ponomarev , Eugene D IL-4/IL-13-dependent and independent expression of miR-124 and its contribution to M2 phenotype of monocytic cells in normal conditions and during allergic inflammation. PLoS ONE, 2013-12-16;8(12):e81774. 2013-12-16 [PMID: 24358127] (Bioassay, Mouse)
• Palm N, Rosenstein R, Yu S, Schenten D, Florsheim E, Medzhitov R Bee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective immunity. Immunity, 2013-10-24;39(5):976-85. 2013-10-24 [PMID: 24210353] (Bioassay, Mouse)
• Cao Q, Wang Y, Zheng D, Sun Y, Wang C, Wang X, Lee V, Wang Y, Zheng G, Tan T, Wang Y, Alexander S, Harris D Failed renoprotection by alternatively activated bone marrow macrophages is due to a proliferation-dependent phenotype switch in vivo. Kidney Int, 2013-09-18;85(4):794-806. 2013-09-18 [PMID: 24048378] (Bioassay, Mouse)
• McHedlidze T, Waldner M, Zopf S, Walker J, Rankin A, Schuchmann M, Voehringer D, McKenzie A, Neurath M, Pflanz S, Wirtz S Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis. Immunity, 2013-08-15;39(2):357-71. 2013-08-15 [PMID: 23954132] (Bioassay, Mouse)
• Mabalirajan U, Rehman R, Ahmad T, Kumar S, Leishangthem G, Singh S, Dinda A, Biswal S, Agrawal A, Ghosh B 12/15-lipoxygenase expressed in non-epithelial cells causes airway epithelial injury in asthma. Sci Rep, 2013-01-01;3(0):1540. 2013-01-01 [PMID: 23528921] (Bioassay, In Vivo, Mouse)
• Starkey M, Essilfie A, Horvat J, Kim R, Nguyen D, Beagley K, Mattes J, Foster P, Hansbro P Constitutive production of IL-13 promotes early-life Chlamydia respiratory infection and allergic airway disease. Mucosal Immunol, 2012-11-07;6(3):569-79. 2012-11-07 [PMID: 23131786] (In Vivo, Mouse)
• Suzukawa M, Morita H, Nambu A, Arae K, Shimura E, Shibui A, Yamaguchi S, Suzukawa K, Nakanishi W, Oboki K, Kajiwara N, Ohno T, Ishii A, Korner H, Cua D, Suto H, Yoshimoto T, Iwakura Y, Yamasoba T, Ohta K, Sudo K, Saito H, Okumura K, Broide D, Matsumoto K, Nakae S Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, Is crucial for murine asthma. J Immunol, 2012-08-31;189(7):3641-52. 2012-08-31 [PMID: 22942422] (Bioassay, Mouse)
• Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A, 2012-06-04;109(25):9971-6. 2012-06-04 [PMID: 22665806] (Bioassay, Mouse)
• Monticelli LA, Sonnenberg GF, Abt MC Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nat. Immunol., 2011-11-01;12(11):1045-54. 2011-11-01 [PMID: 21946417] (Bioassay, In Vivo, Mouse)
• Taube C, Tertilt C, Gyulveszi G, Dehzad N, Kreymborg K, Schneeweiss K, Michel E, Reuter S, Renauld JC, Arnold-Schild D, Schild H, Buhl R, Becher B IL-22 Is Produced by Innate Lymphoid Cells and Limits Inflammation in Allergic Airway Disease. PLoS ONE, 2011-07-18;6(7):e21799. 2011-07-18 [PMID: 21789181] (Bioassay, Mouse)
• Oh MH, Oh SY, Yu J IL-13 induces skin fibrosis in atopic dermatitis by thymic stromal lymphopoietin. J. Immunol., 2011-05-16;186(12):7232-42. 2011-05-16 [PMID: 21576506] (Bioassay, Mouse)
• Asquith KL, Horvat JC, Kaiko GE Interleukin-13 promotes susceptibility to chlamydial infection of the respiratory and genital tracts. PLoS Pathog., 2011-05-05;7(5):e1001339. 2011-05-05 [PMID: 21573182] (In Vivo, Mouse)
• Sehra S, Yao W, Nguyen ET, Ahyi AN, Tuana FM, Ahlfeld SK, Snider P, Tepper RS, Petrache I, Conway SJ, Kaplan MH Periostin regulates goblet cell metaplasia in a model of allergic airway inflammation. J. Immunol., 2011-03-14;186(8):4959-66. 2011-03-14 [PMID: 21402898] (Bioassay, Mouse)
• Zhao A, Urban JF, Sun R Critical role of IL-25 in nematode infection-induced alterations in intestinal function. J. Immunol., 2010-10-25;185(0):6921-9. 2010-10-25 [PMID: 20974983] (In Vivo, Mouse)
• Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. J. Virol., 2010-09-29;84(24):12703-12. 2010-09-29 [PMID: 20881038] (In Vivo, Mouse)
• Mosconi E, Rekima A, Seitz-Polski B Breast milk immune complexes are potent inducers of oral tolerance in neonates and prevent asthma development. Mucosal Immunol, 2010-05-19;3(5):461-74. 2010-05-19 [PMID: 20485331] (ELISA (Standard))
• Horvat JC, Starkey MR, Kim RY, Beagley KW, Preston JA, Gibson PG, Foster PS, Hansbro PM Chlamydial respiratory infection during allergen sensitization drives neutrophilic allergic airways disease. J. Immunol., 2010-03-12;184(8):4159-69. 2010-03-12 [PMID: 20228193] (ELISA (Standard))
• Miyata M, Nakamura Y, Shimokawa N, Ohnuma Y, Katoh R, Matsuoka S, Okumura K, Ogawa H, Masuyama K, Nakao A Thymic stromal lymphopoietin is a critical mediator of IL-13-driven allergic inflammation. Eur. J. Immunol., 2009-11-01;39(11):3078-83. 2009-11-01 [PMID: 19658093] (Bioassay, Mouse)
• Neveu WA, Allard JB, Dienz O, Wargo MJ, Ciliberto G, Whittaker LA, Rincon M IL-6 is required for airway mucus production induced by inhaled fungal allergens. J. Immunol., 2009-07-10;183(3):1732-8. 2009-07-10 [PMID: 19592651] (ELISA (Standard))
• Morimoto M, Zhao A, Sun R, Stiltz J, Madden KB, Mentink-Kane M, Ramalingam T, Wynn TA, Urban JF, Shea-Donohue T IL-13 receptor alpha2 regulates the immune and functional response to Nippostrongylus brasiliensis infection. J. Immunol., 2009-07-08;183(3):1934-9. 2009-07-08 [PMID: 19587021] (In Vivo, Mouse)
• Hudson CA, Christophi GP, Gruber RC, Wilmore JR, Lawrence DA, Massa PT Induction of IL-33 expression and activity in central nervous system glia. J. Leukoc. Biol., 2008-06-13;84(3):631-43. 2008-06-13 [PMID: 18552204] (Bioassay, Mouse)
• Miller R, Sadhukhan R, Wu C Development of an in vitro potency bioassay for therapeutic IL-13 antagonists: the A-549 cell bioassay. J. Immunol. Methods, 2008-03-07;334(1):134-41. 2008-03-07 [PMID: 18355834] (Bioassay, Human)
• Khaled WT, Read EK, Nicholson SE, Baxter FO, Brennan AJ, Came PJ, Sprigg N, McKenzie AN, Watson CJ The IL-4/IL-13/Stat6 signalling pathway promotes luminal mammary epithelial cell development. Development, 2007-07-04;134(15):2739-50. 2007-07-04 [PMID: 17611223] (Bioassay, Mouse)
• Lama VN, Harada H, Badri LN, Flint A, Hogaboam CM, McKenzie A, Martinez FJ, Toews GB, Moore BB, Pinsky DJ Obligatory role for interleukin-13 in obstructive lesion development in airway allografts. Am. J. Pathol., 2006-07-01;169(1):47-60. 2006-07-01 [PMID: 16816360] (In Vivo, Mouse)
• Wen H, Hogaboam CM, Gauldie J, Kunkel SL Severe sepsis exacerbates cell-mediated immunity in the lung due to an altered dendritic cell cytokine profile. Am. J. Pathol., 2006-06-01;168(6):1940-50. 2006-06-01 [PMID: 16723709] (ELISA (Standard))
• Howell MD, Gallo RL, Boguniewicz M, Jones JF, Wong C, Streib JE, Leung DY Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus. Immunity, 2006-03-01;24(3):341-8. 2006-03-01 [PMID: 16546102] (In Vivo, Mouse)
• Schmitz J, Owyang A, Oldham E, Song Y, Murphy E, McClanahan TK, Zurawski G, Moshrefi M, Qin J, Li X, Gorman DM, Bazan JF, Kastelein RA IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity, 2005-11-01;23(5):479-90. 2005-11-01 [PMID: 16286016] (ELISA (Standard))
• Jakubzick C, Choi ES, Kunkel SL, Joshi BH, Puri RK, Hogaboam CM Impact of interleukin-13 responsiveness on the synthetic and proliferative properties of Th1- and Th2-type pulmonary granuloma fibroblasts. Am. J. Pathol., 2003-05-01;162(5):1475-86. 2003-05-01 [PMID: 12707030] (Bioassay, Mouse)
• Herrick CA, Xu L, McKenzie AN, Tigelaar RE, Bottomly K IL-13 is necessary, not simply sufficient, for epicutaneously induced Th2 responses to soluble protein antigen. J. Immunol., 2003-03-01;170(5):2488-95. 2003-03-01 [PMID: 12594274] (In Vivo, Mouse)
• Huaux F, Liu T, McGarry B, Ullenbruch M, Phan SH Dual roles of IL-4 in lung injury and fibrosis. Proteins containing BRCA1 C-terminal (BRCT) domains play crucial roles in response to and repair of DNA damage. Epithelial cell transforming factor ECT2 is a member of the BRCT protein family, but it , 2003-02-15;170(4):2083-92. 2003-02-15 [PMID: 12574379] (Bioassay, Mouse)
• Larbi KY, Dangerfield JP, Culley FJ, Marshall D, Haskard DO, Jose PJ, Williams TJ, Nourshargh S P-selectin mediates IL-13-induced eosinophil transmigration but not eotaxin generation in vivo: a comparative study with IL-4-elicited responses. J. Leukoc. Biol., 2003-01-01;73(1):65-73. 2003-01-01 [PMID: 12525563] (In Vivo, Mouse)
• Kim S, Shim JJ, Burgel PR, Ueki IF, Dao-Pick T, Tam DC, Nadel JA IL-13-induced Clara cell secretory protein expression in airway epithelium: role of EGFR signaling pathway. Am. J. Physiol. Lung Cell Mol. Physiol., 2002-07-01;283(1):L67-75. 2002-07-01 [PMID: 12060562] (In Vivo, Mouse)
• Shi ZO, Fischer MJ, De Sanctis GT, Schuyler MR, Tesfaigzi Y IFN-gamma, but not Fas, mediates reduction of allergen-induced mucous cell metaplasia by inducing apoptosis. J. Immunol., 2002-05-01;168(9):4764-71. 2002-05-01 [PMID: 11971027] (In Vivo, Mouse)

Bioinformatics

• Gene Symbol: Il13
• Uniprot:
  • P20109()