Recombinant Mouse EGF Protein, CF

• Reactivity: Mu
• Applications: Bioactivity
• Format: Carrier-Free

Recombinant Mouse EGF Protein, CF Summary

• Details of Functionality: Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. Rubin, J.S. et al. (1991) Proc. Natl. Acad. Sci. USA 88:415. The ED₅₀ for this effect is 20-100 pg/mL.
• Source: E. coli-derived mouse EGF protein
  Asn977-Arg1029, with an N-terminal Met
• Accession #: NP_034243
• N-terminal Sequence: Met
• Protein/Peptide Type: Recombinant Proteins
• Gene: Egf
• Purity: >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Endotoxin Note: <0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 6.2 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA.
• Purity: >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Reconstitution Instructions: Reconstitute at 200 μg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse EGF Protein, CF

• beta-urogastrone
• EGF
• epidermal growth factor (beta-urogastrone)
• epidermal growth factor
• hEGF
• HOMG4
• pro-epidermal growth factor
• URG
• Urogastrone

Background

Epidermal growth factor (EGF) is a small, potent growth factor capable of inducing cell proliferation, differentiation, and survival. EGF is the founding member of the EGF family that also includes TGF-alpha, amphiregulin (AR), betacellulin (BTC), epiregulin (EPR), heparin‑binding EGF‑like growth factor (HB‑EGF), epigen, and the neuregulins (NRG)-1 through -6 (1). Members of The EGF family are characterized by a shared structural motif, the EGF‑like domain, which contains three intramolecular disulfide bonds that are formed by six similarly spaced, conserved cysteine residues (2). These disulfide bonds are essential for proper protein conformation and receptor binding. All EGF family members are synthesized as type I transmembrane precursor proteins that may contain several EGF domains in the extracellular region. The mature proteins are released from the cell surface by regulated proteolysis (1). The full length EGF protein is 1207 amino acids (aa) (EGF precursor) containing nine EGF domains and nine LDLR class B repeats. However, the mature protein is much smaller, only 53 aa, and is generated by proteolytic cleavage of the EGF domain proximal to the transmembrane region (3). EGF is well conserved across mammals with mature human EGF 70% identical to mature mouse and rat EGF. Physiologically, EGF is found in various body fluids, including blood, milk, urine, saliva, seminal fluid, pancreatic juice, cerebrospinal fluid, and amniotic fluid (4). EGF is a high affinity ligand of the EGF receptor (ErbB). Four ErbB (HER) family receptor tyrosine kinases including EGFR/ErbB1, ErbB2, ErbB3 and ErbB4, mediate responses to EGF family members (5). EGF binding induces dimerization of the EGF receptor resulting in activation of the protein tyrosine kinase signaling pathway. These receptors undergo a complex pattern of ligand-induced homo- or hetero-dimerization to transduce EGF family signals (6, 7). EGF binds ErbB1 and depending on the context, induces the formation of homodimers or heterodimers containing ErbB2. Dimerization results in autophosphorylation of the receptor at specific tyrosine residues to create docking sites for a variety of signaling molecules (5, 8). Biological activities ascribed to EGF include epithelial development, angiogenesis, inhibition of gastric acid secretion, fibroblast proliferation, and colony formation of epidermal cells in culture.

1. Harris, R.C. et al. (2003) Exp. Cell Res. 284:2.
2. Carpenter, G. and Cohen, S. (1990) J. Biol. Chem. 265:7709.
3. Gray, A. et al. (1983) Nature 303:722.
4. Carpenter, G. and Zendegui, J.G. (1986) Exp. Cell Res. 164:1.
5. Jorissen, R.N. et al. (2003) Exp. Cell Res. 284:31.
6. Gamett, D.C. et al. (1997) J. Biol. Chem. 272:12052.
7. Qian, X. et al. (1994) Proc. Natl. Acad. Sci. 91:1500.
8. Qian, X. et al. (1999) J. Biol. Chem. 274:574.

Publications for EGF (2028-EG)(179)

Publications using 2028-EG

• Gu, J;Lv, YF;Xia, JY;Bai, FH;Gong, J;Pan, GQ;Liu, B;Huang, L;Guo, QN;Hao, XL; TC2N maintains stem cell-like characteristics to accelerate lung carcinogenesis by blockade of dual specificity protein phosphatase 3 Cell & bioscience 2025-01-23 [PMID: 39849581] (Bioassay, Mouse)
• Wang, C;Jalali Motlagh, N;Wojtkiewicz, GR;Yang, H;Kim, HH;Chen, JW; A specific and adaptable approach to track CD206+ macrophages by molecular MRI and fluorescence imaging Theranostics 2025-01-01 [PMID: 39776805] (Bioassay, Mouse)
• Mason, DE;Madsen, TD;Gasparski, AN;Jiwnani, N;Lechler, T;Weigert, R;Iglesias-Bartolome, R;Mili, S; Control of Epithelial Tissue Organization by mRNA Localization bioRxiv : the preprint server for biology 2024-12-02 [PMID: 39677649] (Bioassay, Mouse)
• Tresenrider, A;Hooper, M;Todd, L;Kierney, F;Blasdel, NA;Trapnell, C;Reh, TA; A multiplexed, single-cell sequencing screen identifies compounds that increase neurogenic reprogramming of murine Muller glia eLife 2024-12-12 [PMID: 39665620] (Bioassay, Transgenic Mouse)
• Kokkali, M;Karali, K;Thanou, E;Papadopoulou, MA;Zota, I;Tsimpolis, A;Efstathopoulos, P;Calogeropoulou, T;Li, KW;Sidiropoulou, K;Gravanis, A;Charalampopoulos, I; Multimodal beneficial effects of BNN27, a nerve growth factor synthetic mimetic, in the 5xFAD mouse model of Alzheimer's disease Molecular psychiatry 2024-11-25 [PMID: 39587294] (Bioassay, Mouse)
• Ji, X;Sun, Z;Wu, H;Zhang, J;Liu, S;Cao, X;Wang, B;Wang, F;Zhang, Y;Li, B;Feng, J;Zhao, H; More powerful dysregulation of Helicobacter pylori East Asian-type CagA on intracellular signalings BMC microbiology 2024-11-11 [PMID: 39528935] (Bioassay, Mouse)
• Lehle, JD;Lin, YH;Gomez, A;Chavez, L;McCarrey, JR; An in vitro approach reveals molecular mechanisms underlying endocrine disruptor-induced epimutagenesis eLife 2024-10-03 [PMID: 39361026] (Bioassay, Transgenic Mouse)
• Priego, N;de Pablos-Aragoneses, A;Perea-García, M;Pieri, V;Hernandez-Oliver, C;Alvaro-Espinosa, L;Rojas, A;Sanchez, O;Steindl, A;Caleiras, E;Garcia, F;Garcia-Martin, S;Grana-Castro, O;Garcia-Mulero, S;Serrano, D;Velasco-Beltran, P;Jimenez-Lasheras, B;Egia-Mendikute, L;Rupp, L;Stammberger, A;Meinhardt, M;Chaachou-Charradi, A;Martínez-Saez, E;Bertero, L;Cassoni, P;Mangherini, L;Pellerino, A;Ruda, R;Soffietti, R;Al-Shahrour, F;Saftig, P;Sanz-Pamplona, R;Schmitz, M;Crocker, SJ;Calvo, A;Palazon, A;Group, R;Valiente, M; TIMP1 mediates astrocyte-dependent local immunosuppression in brain metastasis acting on infiltrating CD8+ T cells Cancer discovery 2024-10-02 [PMID: 39354883] (Bioassay, Mouse)
• Feng, M;Wang, J;Zhao, X;Du, H;Dai, Y; Novel Insight into the mechanism of di (2-ethylhexyl) phthalate (DEHP) impairing early follicle development Ecotoxicology and environmental safety 2024-09-17 [PMID: 39293100] (Bioassay, Mouse)
• Boucherie, C;Alkailani, M;Jossin, Y;Ruiz-Reig, N;Mahdi, A;Aldaalis, A;Aittaleb, M;Tissir, F; Auts2 enhances neurogenesis and promotes expansion of the cerebral cortex Journal of advanced research 2024-07-14 [PMID: 39013538] (Bioassay, Mouse)
• Milani, M;Canepari, C;Assanelli, S;Merlin, S;Borroni, E;Starinieri, F;Biffi, M;Russo, F;Fabiano, A;Zambroni, D;Annoni, A;Naldini, L;Follenzi, A;Cantore, A; GP64-pseudotyped lentiviral vectors target liver endothelial cells and correct hemophilia A mice EMBO molecular medicine 2024-04-29 [PMID: 38684862] (Bioassay, Mouse, Transgenic Mouse)
• Namoto, K;Baader, C;Orsini, V;Landshammer, A;Breuer, E;Dinh, KT;Ungricht, R;Pikiolek, M;Laurent, S;Lu, B;Aebi, A;Schönberger, K;Vangrevelinghe, E;Evrova, O;Sun, T;Annunziato, S;Lachal, J;Redmond, E;Wang, L;Wetzel, K;Capodieci, P;Turner, J;Schutzius, G;Unterreiner, V;Trunzer, M;Buschmann, N;Behnke, D;Machauer, R;Scheufler, C;Parker, CN;Ferro, M;Grevot, A;Beyerbach, A;Lu, WY;Forbes, SJ;Wagner, J;Bouwmeester, T;Liu, J;Sohal, B;Sahambi, S;Greenbaum, LE;Lohmann, F;Hoppe, P;Cong, F;Sailer, AW;Ruffner, H;Glatthar, R;Humar, B;Clavien, PA;Dill, MT;George, E;Maibaum, J;Liberali, P;Tchorz, JS; NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo Cell stem cell 2024-04-04 [PMID: 38579685] (Bioassay, Mouse)
• Kawasaki, M;Ambrosini, YM; Accessible luminal interface of bovine rectal organoids generated from cryopreserved biopsy tissues PloS one 2024-03-21 [PMID: 38512940] (Bioassay, Bovine)
• Gaudino, SJ;Singh, A;Huang, H;Padiadpu, J;Jean-Pierre, M;Kempen, C;Bahadur, T;Shiomitsu, K;Blumberg, R;Shroyer, KR;Beyaz, S;Shulzhenko, N;Morgun, A;Kumar, P; Intestinal IL-22RA1 signaling regulates intrinsic and systemic lipid and glucose metabolism to alleviate obesity-associated disorders Nature communications 2024-02-21 [PMID: 38383607] (Bioassay, Mouse)
• Verdikt, R;Armstrong, AA;Cheng, J;Hwang, YS;Clark, AT;Yang, X;Allard, P; Metabolic memory of ?9-tetrahydrocannabinol exposure in pluripotent stem cells and primordial germ cells-like cells eLife 2023-12-27 [PMID: 38150302] (Cell Culture, Mouse)
• Pereira, M;Glogova, A;Haagsma, J;Stewart, J;Shepherd, TG;Petrik, J; Mutant p53 murine oviductal epithelial cells induce progression of high-grade serous carcinoma and are most sensitive to simvastatin therapy in vitro and in vivo Journal of ovarian research 2023-11-20 [PMID: 37986175] (Bioassay, Mouse)
• Read, E;Peña-Cearra, A;Coman, D;Jowett, GM;W H Chung, M;Coales, I;Syntaka, S;Finlay, RE;Tachó-Piñot, R;van Der Post, S;Naizi, U;Roberts, LB;Hepworth, MR;Curtis, MA;Neves, JF; Bi-directional signalling between the intestinal epithelium and type-3 innate lymphoid cells (ILC3) regulates secretory dynamics and IL-22 Mucosal immunology 2023-11-10 [PMID: 37952849] (Bioassay, Mouse)
• Hung, YH;Capeling, M;Villanueva, JW;Kanke, M;Shanahan, MT;Huang, S;Cubitt, R;Rinaldi, VD;Schimenti, JC;Spence, JR;Sethupathy, P; Integrative genome-scale analyses reveal post-transcriptional signatures of early human small intestinal development in a directed differentiation organoid model BMC genomics 2023-10-26 [PMID: 37884859] (Mouse)
• Korwin-Mihavics, BR;Dews, EA;Martorelli di Genova, B;Huston, CD; Organoid-based in vitro systems to model Cryptosporidium parvum infection in 2D and 3D bioRxiv : the preprint server for biology 2023-09-29 [PMID: 37808810] (Bioassay, Mouse)
• Tresenrider, A;Hooper, M;Todd, L;Kierney, F;Blasdel, N;Trapnell, C;Reh, TA; A multiplexed, single-cell sequencing screen identifies compounds that increase neurogenic reprogramming of murine Muller glia bioRxiv : the preprint server for biology 2023-09-27 [PMID: 37808650] (Bioassay, Transgenic Mouse)
• Williams, C;Brown, R;Zhao, Y;Wang, J;Chen, Z;Blunt, K;Pilat, J;Parang, B;Choksi, Y;Lau, K;Hiebert, S;Short, S;Jacobse, J;Xu, Y;Yang, Y;Goettel, J; MTGR1 is required to maintain small intestinal stem cell populations Research square 2023-09-21 [PMID: 37790452] (Bioassay, Mouse)
• Loxha, L;Ibrahim, NK;Stasche, AS;Cinar, B;Dolgner, T;Niessen, J;Schreek, S;Fehlhaber, B;Forster, M;Stanulla, M;Hinze, L; GSK3? Regulates Temporally Dynamic Changes in Ribosomal Proteins upon Amino Acid Starvation in Cancer Cells International journal of molecular sciences 2023-08-26 [PMID: 37686063] (Bioassay, Transgenic Mouse)
• S Scharaw, A Sola-Carva, I Belevich, AT Webb, S Das, S Andersson, N Pentinmikk, EJ Villablanc, JR Goldenring, E Jokitalo, RJ Coffey, P Katajisto Golgi organization is a determinant of stem cell function in the small intestine bioRxiv : the preprint server for biology, 2023-03-24;0(0):. 2023-03-24 [PMID: 36993731] (Bioassay, Mouse)
• Qing Luo, Han-pin Pui, Jiayu Chen, Leqian Yu, Paulo R. Jannig, Yu Pei et al. Epiblast-like stem cells established by Wnt/ beta -catenin signaling manifest distinct features of formative pluripotency and germline competence Cell Reports 2023-01-31 [PMID: 36848234] (Bioassay, Mouse)
• L Sun, Y Zhang, J Cai, B Rimal, ER Rocha, JP Coleman, C Zhang, RG Nichols, Y Luo, B Kim, Y Chen, KW Krausz, CC Harris, AD Patterson, Z Zhang, S Takahashi, FJ Gonzalez Bile salt hydrolase in non-enterotoxigenic Bacteroides potentiates colorectal cancer Nature Communications, 2023-02-10;14(1):755. 2023-02-10 [PMID: 36765047] (Bioassay, Mouse)
• FM Yavitt, BE Kirkpatric, MR Blatchley, KF Speckl, E Mohagheghi, R Moldovan, N Wang, PJ Dempsey, KS Anseth In situ modulation of intestinal organoid epithelial curvature through photoinduced viscoelasticity directs crypt morphogenesis Science Advances, 2023-01-20;9(3):eadd5668. 2023-01-20 [PMID: 36662859] (Bioassay, Mouse)
• M Hayashi, V Zywitza, Y Naitou, N Hamazaki, F Goeritz, R Hermes, S Holtze, G Lazzari, C Galli, J Stejskal, S Diecke, TB Hildebrand, K Hayashi Robust induction of primordial germ cells of white rhinoceros on the brink of extinction Science Advances, 2022-12-09;8(49):eabp9683. 2022-12-09 [PMID: 36490332] (Bioassay, Rhinoceros)
• O Weeks, BM Miller, BJ Pepe-Moone, IM Oderberg, SH Freeburg, CJ Smith, TE North, W Goessling Embryonic alcohol exposure disrupts the ubiquitin-proteasome system JCI Insight, 2022-12-08;7(23):. 2022-12-08 [PMID: 36477359] (Cell Culture, Mouse)
• JW Villanueva, L Kwong, T Han, SA Martinez, MT Shanahan, M Kanke, LE Dow, CG Danko, P Sethupathy Comprehensive microRNA analysis across genome-edited colorectal cancer organoid models reveals miR-24 as a candidate regulator of cell survival BMC Genomics, 2022-12-01;23(1):792. 2022-12-01 [PMID: 36457077] (Bioassay, Mouse)
• L Todd, W Jenkins, C Finkbeiner, MJ Hooper, PC Donaldson, M Pavlou, J Wohlschleg, N Ingram, F Rieke, TA Reh Reprogramming M�ller glia to regenerate ganglion-like cells in adult mouse retina with developmental transcription factors Science Advances, 2022-11-23;8(47):eabq7219. 2022-11-23 [PMID: 36417510] (Bioassay, Transgenic Mouse)
• E Bozzato, N Tsakiris, A Paquot, GG Muccioli, C Bastiancic, V Préat Dual-drug loaded nanomedicine hydrogel as a therapeutic platform to target both residual glioblastoma and glioma stem cells International journal of pharmaceutics, 2022-10-28;628(0):122341. 2022-10-28 [PMID: 36341916] (Bioassay, Mouse)
• N Pentinmikk, R Lozano, S Scharaw, S Andersson, JI Englund, D Castillo-A, A Gallagher, M Broberg, KY Song, A Sola Carva, AT Speidel, M Sundstrom, N Allbritton, MM Stevens, OD Klein, A Teixeira, P Katajisto Cellular shape reinforces niche to stem cell signaling in the small intestine Science Advances, 2022-10-14;8(41):eabm1847. 2022-10-14 [PMID: 36240269] (Bioassay, Mouse)
• G de Medeiro, R Ortiz, P Strnad, A Boni, F Moos, N Repina, L Challet Me, F Maurer, P Liberali Multiscale light-sheet organoid imaging framework Nature Communications, 2022-08-18;13(1):4864. 2022-08-18 [PMID: 35982061] (Cell Culture, Human)
• J Zhong, X Yang, J Chen, K He, X Gao, X Wu, M Zhang, H Zhou, F Xiao, L An, X Wang, Y Shi, N Zhang Circular EZH2-encoded EZH2-92aa mediates immune evasion in glioblastoma via inhibition of surface NKG2D ligands Nature Communications, 2022-08-15;13(1):4795. 2022-08-15 [PMID: 35970825] (Bioassay, Mouse)
• L Kennedy, ER Glesaaen, V Palibrk, M Pannone, W Wang, A Al-Jabri, R Suganthan, N Meyer, ML Austbø, X Lin, LH Bergersen, M Bjørås, JE Rinholm Lactate receptor HCAR1 regulates neurogenesis and microglia activation after neonatal hypoxia-ischemia Elife, 2022-08-09;11(0):. 2022-08-09 [PMID: 35942676] (Cell Culture, Mouse)
• R Mano, T Tanaka, S Hashiguchi, H Takahashi, N Sakata, S Kondo, S Kodama Induction of potassium channel regulator KCNE4 in a submandibular lymph node metastasis model Scientific Reports, 2022-08-01;12(1):13208. 2022-08-01 [PMID: 35915077] (Bioassay, Mouse)
• M von Joest, C Chen, T Douché, J Chantrel, A Chiche, QG Gianetto, M Matondo, H Li Amphiregulin mediates non-cell-autonomous effect of senescence on reprogramming Oncogene, 2022-07-12;40(2):111074. 2022-07-12 [PMID: 35830812] (Bioassay, Mouse)
• C Chen, Q Yu, Y Huang, XQ Shen, ZZ Ding, GW Chen, J Yan, QG Gu, X Mao Research on the function of the Cend1 regulatory mechanism on p75NTR signaling in spinal cord injury Neuropeptides, 2022-06-08;95(0):102264. 2022-06-08 [PMID: 35728483] (Bioassay, Mouse)
• ZZ Hao, JR Wei, D Xiao, R Liu, N Xu, L Tang, M Huang, Y Shen, C Xing, W Huang, X Liu, M Xiang, Y Liu, Z Miao, S Liu Single-cell transcriptomics of adult macaque hippocampus reveals neural precursor cell populations Nature Neuroscience, 2022-05-30;25(6):805-817. 2022-05-30 [PMID: 35637371] (Bioassay, Rhesus Macaque)
• Y Han, M King, E Tikhomirov, P Barasa, CDS Souza, J Lindh, D Baltriukie, L Ferraiuolo, M Azzouz, MR Gullo, EN Kozlova Towards 3D Bioprinted Spinal Cord Organoids International Journal of Molecular Sciences, 2022-05-21;23(10):. 2022-05-21 [PMID: 35628601] (Bioassay, Mouse)
• J Döhla, E Kuuluvaine, N Gebert, A Amaral, JI Englund, S Gopalakris, S Konovalova, AI Nieminen, ES Salminen, R Torregrosa, K Ahlqvist, Y Yang, H Bui, T Otonkoski, R Käkelä, V Hietakanga, H Tyynismaa, A Ori, P Katajisto Metabolic determination of cell fate through selective inheritance of mitochondria Nature Cell Biology, 2022-02-14;24(2):148-154. 2022-02-14 [PMID: 35165416] (Bioassay, Mouse)
• C Dong, X Wang, L Sun, L Zhu, D Yang, S Gao, W Zhang, B Ling, A Liang, Z Gao, J Xu ATM modulates subventricular zone neural stem cell maintenance and senescence through Notch signaling pathway Stem Cell Research, 2021-12-07;58(0):102618. 2021-12-07 [PMID: 34915311] (Bioassay, Mouse)
• X Yuan, X Ma, L Yang, Q Zhou, Y Li beta-blocker eye drops affect ocular surface through beta2 adrenoceptor of corneal limbal stem cells BMC ophthalmology, 2021-12-05;21(1):419. 2021-12-05 [PMID: 34863129] (Bioassay, Mouse)
• Z Shi, Y Mori-Akiya, W Du, R Fultz, Y Zhao, W Ruan, S Venable, MA Engevik, J Versalovic Loss of H2R signaling disrupts neutrophil homeostasis and promotes inflammation-associated colonic tumorigenesis in mice Cellular and Molecular Gastroenterology and Hepatology, 2021-11-13;0(0):. 2021-11-13 [PMID: 34781022] (Bioassay, Mouse)
• L Todd, MJ Hooper, AK Haugan, C Finkbeiner, N Jorstad, N Radulovich, CK Wong, PC Donaldson, W Jenkins, Q Chen, F Rieke, TA Reh Efficient stimulation of retinal regeneration from M�ller glia in adult mice using combinations of proneural bHLH transcription factors Cell Reports, 2021-10-19;37(3):109857. 2021-10-19 [PMID: 34686336] (Bioassay, Mouse)
• SKT Ooi, H Jiang, Y Kang, P Allard Examining the Developmental Trajectory of an in Vitro Model of Mouse Primordial Germ Cells following Exposure to Environmentally Relevant Bisphenol A Levels Environmental health perspectives, 2021-09-29;129(9):97013. 2021-09-29 [PMID: 34585602] (Bioassay, Mouse)
• Y Ishikura, H Ohta, T Sato, Y Murase, Y Yabuta, Y Kojima, C Yamashiro, T Nakamura, T Yamamoto, T Ogawa, M Saitou In�vitro reconstitution of the whole male germ-cell development from mouse pluripotent stem cells Cell Stem Cell, 2021-09-07;0(0):. 2021-09-07 [PMID: 34496297] (Bioassay, Mouse)
• K Tong, OA Kothari, KS Haro, A Panda, MM Bandari, JN Carrick, JJ Hur, L Zhang, CS Chan, J Xing, ML Gatza, S Ganesan, MP Verzi SMAD4 is critical in suppression of BRAF-V600E serrated tumorigenesis Oncogene, 2021-08-27;0(0):. 2021-08-27 [PMID: 34453124] (Bioassay, Mouse)
• T Sun, S Annunziato, S Bergling, C Sheng, V Orsini, P Forcella, M Pikiolek, V Kancherla, S Holwerda, D Imanci, F Wu, LC Meylan, LF Puehringer, A Waldt, M Oertli, S Schuierer, LM Terraccian, S Reinker, H Ruffner, T Bouwmeeste, AW Sailer, E George, G Roma, A de Weck, S Piscuoglio, F Lohmann, U Naumann, P Liberali, F Cong, JS Tchorz ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation Cell Stem Cell, 2021-06-14;0(0):. 2021-06-14 [PMID: 34129813] (Bioassay, Mouse)
• X Wang, Y Xiang, Y Yu, R Wang, Y Zhang, Q Xu, H Sun, ZA Zhao, X Jiang, X Wang, X Lu, D Qin, Y Quan, J Zhang, N Shyh-Chang, H Wang, N Jing, W Xie, L Li Formative pluripotent stem cells show features of epiblast cells poised for gastrulation Cell Research, 2021-02-19;0(0):. 2021-02-19 [PMID: 33608671] (Bioassay, Mouse)
• A Shintani, M Higuchi Isolation of PRRX1-positive adult pituitary stem/progenitor cells from the marginal cell layer of the mouse anterior lobe Stem Cell Research, 2021-02-02;52(0):102223. 2021-02-02 [PMID: 33561660] (Bioassay, Mouse)
• I Paredes, JR Vieira, B Shah, CF Ramunno, J Dyckow, H Adler, M Richter, G Schermann, E Giannakour, L Schirmer, HG Augustin, C Ruiz de Al Oligodendrocyte precursor cell specification is regulated by bidirectional neural progenitor-endothelial cell crosstalk Nature Neuroscience, 2021-01-28;0(0):. 2021-01-28 [PMID: 33510480] (Bioassay, Mouse)
• M Kubota, M Scheibinge, TA Jan, S Heller Greater epithelial ridge cells are the principal organoid-forming progenitors of the mouse cochlea Cell Reports, 2021-01-19;34(3):108646. 2021-01-19 [PMID: 33472062] (Bioassay, Mouse)
• S Tanigawa, M Fujita, C Moyama, S Ando, H Ii, Y Kojima, T Fujishita, M Aoki, H Takeuchi, T Yamanaka, Y Takahashi, N Hashimoto, S Nakata Inhibition of Gli2 suppresses tumorigenicity in glioblastoma stem cells derived from a de novo murine brain cancer model Cancer Gene Therapy, 2021-01-07;0(0):. 2021-01-07 [PMID: 33414520] (Bioassay, Mouse)
• AE Engler, AB Ysasi, RMF Pihl, C Villacorta, HM Heston, HMK Richardson, BR Thapa, NR Moniz, AC Belkina, SA Mazzilli, JR Rock Airway-Associated Macrophages in Homeostasis and Repair Cell Reports, 2020-12-29;33(13):108553. 2020-12-29 [PMID: 33378665]
• L Todd, C Finkbeiner, CK Wong, MJ Hooper, TA Reh Microglia Suppress Ascl1-Induced Retinal Regeneration in Mice Cell Reports, 2020-12-15;33(11):108507. 2020-12-15 [PMID: 33326790] (Bioassay, Transgenic Mouse)
• MF Leyton-Jai, P Ivert, J Hoeber, Y Han, A Feiler, C Zhou, S Pankratova, V Shoshan-Ba, A Israelson, EN Kozlova Empty mesoporous silica particles significantly delay disease progression and extend survival in a mouse model of ALS Sci Rep, 2020-11-26;10(1):20675. 2020-11-26 [PMID: 33244084] (Cell Culture, Mouse)
• AJ Bilotta, C Ma, W Yang, Y Yu, Y Yu, X Zhao, Z Zhou, S Yao, SM Dann, Y Cong Propionate Enhances Cell Speed and Persistence to Promote Intestinal Epithelial Turnover and Repair Cell Mol Gastroenterol Hepatol, 2020-11-22;0(0):. 2020-11-22 [PMID: 33238220] (Cell Culture, Mouse)
• D Chakravart, B Hu, X Mao, A Rashid, J Li, J Li, WT Liao, EM Whitley, P Dey, P Hou, KA LaBella, A Chang, G Wang, DJ Spring, P Deng, D Zhao, X Liang, Z Lan, Y Lin, S Sarkar, C Terranova, YL Deribe, SE Blutt, P Okhuysen, J Zhang, E Vilar, OH Nielsen, A Dupont, M Younes, KR Patel, NF Shroyer, K Rai, MK Estes, YA Wang, AA Bertuch, RA DePinho Telomere dysfunction activates YAP1 to drive tissue inflammation Nat Commun, 2020-09-21;11(1):4766. 2020-09-21 [PMID: 32958778] (Bioassay, Mouse)
• T Horai, S Boku, S Okazaki, I Otsuka, W Ratta-Apha, K Mouri, N Yamaki, T Hirata, A Hishimoto miR-19b is elevated in peripheral blood of schizophrenic patients and attenuates proliferation of hippocampal neural progenitor cells J Psychiatr Res, 2020-09-11;131(0):102-107. 2020-09-11 [PMID: 32950706] (Cell Culture, Mouse)
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Bioinformatics

• Gene Symbol: Egf
• Uniprot:
  • NP_034243()