Recombinant Human P-Selectin/CD62P Protein, CF


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Reactivity HuSpecies Glossary
Applications Bioactivity

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Recombinant Human P-Selectin/CD62P Protein, CF Summary

Details of Functionality
Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells. When 5 x 104 cells/well are added to human sP-Selectin coated plates (10 μg/mL with 100 μL/well), >50% will adhere after 1 hour incubation at room temperature.
Chinese Hamster Ovary cell line, CHO-derived human P-Selectin/CD62P protein
Accession #
N-terminal Sequence
Protein/Peptide Type
Recombinant Proteins
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.


Theoretical MW
80 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
121-124 kDa, reducing conditions
Read Publications using
ADP3 in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS containing Calcium and Magnesium with Sorbitol.
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Reconstitution Instructions
Reconstitute at 1 mg/mL in sterile, deionized water.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human P-Selectin/CD62P Protein, CF

  • CD62P antigen
  • CD62P
  • FLJ45155
  • GMP140
  • GRMP
  • PADGEMantigen CD62)
  • PSEL
  • P-Selectin
  • selectin P (granule membrane protein 140kDa, antigen CD62)
  • SELP


Human P-Selectin (GMP-140, LECAM-3, PADGEM, CD62P), a member of the Selectin family, is a cell surface glycoprotein expressed by activated platelets and endothelial cells. P-Selectin is translocated to the cell surface within minutes, from alpha granules of platelets or Weibel-Palade bodies of endothelial cells, following stimulation with thrombin, histamine, PMA or peroxides. P-Selectin binds to a 106 kDa protein present on myeloid cells, neutrophils, monocytes and lymphocytes, termed PSGL-1 (P-Selectin glycoprotein ligand-1).

P-Selectin plays a role in the adhesion of leukocytes and neutrophils to the endothelium. Acting in cooperation with L Selectin,P-Selectin mediates the initial interaction of circulating leukocytes with endothelial cells that produces a characteristic ‘rolling' of the leukocytes on the endothelium. This initial interaction is followed by a stronger interaction involving E-Selectin, and later ICAM-1 and VCAM-1, that leads eventually to extravasation of the white blood cell through the blood vessel wall into the extracellular matrix tissue.

ELISA techniques have shown that detectable levels of soluble P-Selectin are present in the biological fluids of apparently normal individuals. Furthermore, a number of studies have reported that levels of P-Selectin may be elevated or lowered in subjects with a variety of pathological conditions.

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Publications for P-Selectin/CD62P (ADP3)(14)

We have publications tested in 3 confirmed species: Human, Rat, N/A.

We have publications tested in 5 applications: Binding Assay, Bioassay, Cell Culture, ELISA Developmet, In Vivo.

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Showing Publications 1 - 10 of 14. Show All 14 Publications.
Publications using ADP3 Applications Species
R Fitterer, T Lajqi, SA Kranig, M Braun, N Theissig, N Kuss, J Pöschl, D Frommhold, H Hudalla L-Arginine Modulates Neonatal Leukocyte Recruitment in a Gestational Age-Dependent Manner J Clin Med, 2020;9(9):. 2020 [PMID: 32867030] (Bioassay, Human) Bioassay Human
V Rolfes, LS Ribeiro, I Hawwari, L Böttcher, N Rosero, S Maasewerd, MLS Santos, T Próchnicki, CMS Silva, CWS Wanderley, M Rothe, SV Schmidt, HJ Stunden, D Bertheloot, MN Rivas, CJ Fontes, LH Carvalho, FQ Cunha, E Latz, M Arditi, BS Franklin Platelets Fuel the Inflammasome Activation of Innate Immune Cells Cell Rep, 2020;31(6):107615. 2020 [PMID: 32402278] (Cell Culture, Human) Cell Culture Human
Z Ye, L Zhong, S Zhu, Y Wang, J Zheng, S Wang, J Zhang, R Huang The P-selectin and PSGL-1 axis accelerates atherosclerosis via activation of dendritic cells by the TLR4 signaling pathway Cell Death Dis, 2019;10(7):507. 2019 [PMID: 31263109] (Bioassay, Human) Bioassay Human
J Perdomo, HHL Leung, Z Ahmadi, F Yan, JJH Chong, FH Passam, BH Chong Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia Nat Commun, 2019;10(1):1322. 2019 [PMID: 30899022] (Bioassay, Human) Bioassay Human
MJ Domínguez-, E Armas-Gonz, A Herrera-Ga, M Arce-Franc, M Feria, M Vicente-Ma, A Martínez-R, F Sánchez-Ma, F Díaz-Gonzá L-selectin expression is regulated by CXCL8-induced reactive oxygen species produced during human neutrophil rolling Eur. J. Immunol., 2018;0(0):. 2018 [PMID: 30443903] (Bioassay, Human) Bioassay Human
Soluble Siglec-5 associates to PSGL-1 and displays anti-inflammatory activity Sci Rep, 2016;6(0):37953. 2016 [PMID: 27892504] (ELISA Developmet, N/A) ELISA Developmet N/A
Platelets Guide Leukocytes to Their Sites of Extravasation PLoS Biol, 2016;14(5):e1002459. 2016 [PMID: 27152726] (Bioassay, Human) Bioassay Human
Jung C, Yeh C, Hsu R, Lee C, Shun C, Chia J Endocarditis pathogen promotes vegetation formation by inducing intravascular neutrophil extracellular traps through activated platelets. Circulation, 2015;131(6):571-81. 2015 [PMID: 25527699] (Bioassay, Human) Bioassay Human
Jang M, Kim Y, Bae E, Oh T, Choi H, Lee J, Oh H, Lee S Saikosaponin D isolated from Bupleurum falcatum inhibits selectin-mediated cell adhesion. Molecules, 2014;19(12):20340-9. 2014 [PMID: 25486247] (Bioassay, Human) Bioassay Human
Schneider-Hohendorf T, Rossaint J, Mohan H, Boning D, Breuer J, Kuhlmann T, Gross C, Flanagan K, Sorokin L, Vestweber D, Zarbock A, Schwab N, Wiendl H VLA-4 blockade promotes differential routes into human CNS involving PSGL-1 rolling of T cells and MCAM-adhesion of TH17 cells. J Exp Med, 2014;211(9):1833-46. 2014 [PMID: 25135296] (Bioassay, Human) Bioassay Human
Show All 14 Publications.

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Gene Symbol SELP