Recombinant Human LBP Protein, CF

Images

 
There are currently no images for LBP (870-LP/CF).

Every product we sell is backed by Novus' 100% Guarantee. If you have used this product, please submit your images and reviews to earn reward points.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Bioactivity
Format
Carrier-Free

Order Details

View Available Formulations
Catalog# & Formulation Size Price

Recombinant Human LBP Protein, CF Summary

Additional Information
A New rhLBP is Now Available! The new protein has a His-tag!
New Product 6445-LP/CF
Details of Functionality
Measured by its ability to enhance LPS-stimulated IL-8 secretion by THP‑1 human acute monocytic leukemia cells. The ED50 for this effect is 0.25‑2.5 ng/mL.
Source
Mouse myeloma cell line, NS0-derived human LBP protein
Ala26-Val481
Accession #
N-terminal Sequence
Ala26
Protein/Peptide Type
Recombinant Proteins
Gene
LBP
Purity
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Theoretical MW
51 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
SDS-PAGE
55-60 kDa, reducing conditions
Publications
Read Publications using
870-LP/CF in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in Tris, NaCl and EDTA.
Purity
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Reconstitution Instructions
Reconstitute at 100 μg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human LBP Protein, CF

  • LBP
  • lipopolysaccharide binding protein
  • lipopolysaccharide-binding protein
  • LPS-binding protein
  • MGC22233

Background

Lipopolysaccharide-binding protein (LBP), a 58 kDa glycoprotein synthesized in hepatocytes, belongs to a family of lipid-binding proteins which includes bactericidal/permeability increasing protein (BPI), phospholipid ester transfer protein (PLTP), and cholesterol ester transfer protein (CETP). LBP binds to the lipid A portion of lipopolysaccharide (LPS) to facilitate the process of LPS monomerization, catalyze the binding of LPS monomers to CD14, and promote LPS-induced immune response. LBP is present at low concentrations in normal human serum and may increase up to 30-fold during the acute phase response. Studies indicate that LBP also acts catalytically in the transfer of LPS to HDL, thus accelerating LPS detoxification. In addition, LBP and soluble CD14 can also function in phospholipid transport.

  1. Hailman, E. et al. (1994) J. Exp. Med. 179:269.
  2. Jack, R.S. et al. (1997) Nature 389:742.
  3. Schumann, R.R. et al. (2000) Chem. Immunol. 74:42.

Customers Who Viewed This Item Also Viewed...

NB100-56566
Species: Hu, Mu, Rt
Applications: WB, ChIP, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, In vitro, CyTOF-ready, ELISA(Cap), Flow-CS, Flow-IC
NBP2-37982
Species: Hu
Applications: IHC, IHC-P
NB100-56655
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P
NB100-524
Species: Hu, Mu
Applications: WB, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, Flow-IC
AF-386-PB
Species: Hu
Applications: WB, Flow, CyTOF-ready, ICC
NBP1-84550
Species: Hu
Applications: WB, IHC, IHC-P
NB100-56722
Species: Hu, Ca
Applications: WB, Flow, ICC/IF, IHC-P, IP, B/N, Flow-CS
AF5739
Species: Hu, Mu, Rt
Applications: WB
MAB208
Species: Hu
Applications: WB, CyTOF-ready, ELISA(Cap), ELISA(Det), ICC, ICFlow, Neut, ELISA(Sta)
NB100-56583
Species: Hu
Applications: WB, Flow, IHC-P
NBP2-66881
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
NB600-41532
Species: Mu
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
870-LP/CF
Species: Hu
Applications: Bioactivity

Publications for LBP (870-LP/CF)(11)

We have publications tested in 2 confirmed species: Human, Chicken.

We have publications tested in 3 applications: Bioassay, Bioassay - Ctrl, EnzAct.


Filter By Application
Bioassay
(9)
Bioassay - Ctrl
(1)
EnzAct
(1)
All Applications
Filter By Species
Human
(9)
Chicken
(1)
All Species
Showing Publications 1 - 10 of 11. Show All 11 Publications.
Publications using 870-LP/CF Applications Species
SJ Higgins, K Ceunynck, J Kellum, X Chen, X Gu, SA Chaudhry, S Schulman, TA Libermann, S Lu, NI Shapiro, DC Christiani, R Flaumenhaf, SM Parikh Tie2 protects the vasculature against thrombus formation in systemic inflammation J. Clin. Invest., 2018;0(0):. 2018 [PMID: 29360642] (Bioassay, Human) Bioassay Human
R Lehmann, MM Müller, TE Klassert, D Driesch, M Stock, A Heinrich, T Conrad, C Moore, UK Schier, R Guthke, H Slevogt Differential regulation of the transcriptomic and secretomic landscape of sensor and effector functions of human airway epithelial cells Mucosal Immunol, 2018;0(0):. 2018 [PMID: 29297499] (Bioassay, Human) Bioassay Human
PH Ding, RP Darveau, CY Wang, L Jin 3LPS-binding protein and its interactions with P. gingivalis LPS modulate pro-inflammatory response and Toll-like receptor signaling in human oral keratinocytes PLoS ONE, 2017;12(4):e0173223. 2017 [PMID: 28384159] (Bioassay, Human) Bioassay Human
B S Lashkari, DO Anumba Estradiol alters the immune-responsiveness of cervical epithelial cells stimulated with ligands of Toll-like receptors 2 and 4 PLoS ONE, 2017;12(3):e0173646. 2017 [PMID: 28296959] (Bioassay, Human) Bioassay Human
Annette C Wensink Granzymes A and K differentially potentiate LPS-induced cytokine response Cell Death Discov, 2016;2(0):16084. 2016 [PMID: 28028441] (Bioassay) Bioassay
Fang L, Xu Z, Wang G, Ji F, Mei C, Liu J, Wu G Directed evolution of an LBP/CD14 inhibitory peptide and its anti-endotoxin activity. PLoS ONE, 2014;9(7):e101406. 2014 [PMID: 25025695] (EnzAct, Human) EnzAct Human
Canault M, Ghalloussi D, Grosdidier C, Guinier M, Perret C, Chelghoum N, Germain M, Raslova H, Peiretti F, Morange P, Saut N, Pillois X, Nurden A, Cambien F, Pierres A, van den Berg T, Kuijpers T, Alessi M, Tregouet D Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding. J Exp Med, 2014;211(7):1349-62. 2014 [PMID: 24958846] (Bioassay, Human) Bioassay Human
Cordeiro, Cristian, Esmaili, Hamed, Ansah, George, Hincke, Maxwell Ovocalyxin-36 is a pattern recognition protein in chicken eggshell membranes. PLoS ONE, 2013;8(12):e84112. 2013 [PMID: 24391897] (Bioassay - Ctrl, Chicken) Bioassay - Ctrl Chicken
Malachowa N, Kobayashi S, Freedman B, Dorward D, DeLeo F Staphylococcus aureus leukotoxin GH promotes formation of neutrophil extracellular traps. J Immunol, 2013;191(12):6022-9. 2013 [PMID: 24190656] (Bioassay, Human) Bioassay Human
Gupta N, Li W, Willard B, Silverstein R, McIntyre T Proteasome proteolysis supports stimulated platelet function and thrombosis. Arterioscler Thromb Vasc Biol, 2014;34(1):160-8. 2014 [PMID: 24177323] (Bioassay, Human) Bioassay Human
Show All 11 Publications.

Reviews for LBP (870-LP/CF) (0)

There are no reviews for LBP (870-LP/CF). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen
  • 1st to review with an image -- $50/€35/£30/$50 CAD/¥300 Yuan/¥5000 Yen

FAQs for LBP (870-LP/CF) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Customers Who Bought This Also Bought

Contact Information

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our Recombinant Human LBP Protein, CF and receive a gift card or discount.

Bioinformatics

Gene Symbol LBP
Entrez
Uniprot