Recombinant Human LBP Protein, CF


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Product Details

Reactivity HuSpecies Glossary
Applications Bioactivity

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Recombinant Human LBP Protein, CF Summary

Additional Information
A New rh LBP is Now Available! The new protein has a His-tag!
Details of Functionality
Measured by its ability to enhance LPS-stimulated IL-8 secretion by THP‑1 human acute monocytic leukemia cells. The ED50 for this effect is 0.25‑2.5 ng/mL.
Mouse myeloma cell line, NS0-derived human LBP protein
Accession #
N-terminal Sequence
Protein/Peptide Type
Recombinant Proteins
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.


Theoretical MW
51 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
55-60 kDa, reducing conditions
Read Publications using
870-LP/CF in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in Tris, NaCl and EDTA.
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Reconstitution Instructions
Reconstitute at 100 μg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human LBP Protein, CF

  • LBP
  • lipopolysaccharide binding protein
  • lipopolysaccharide-binding protein
  • LPS-binding protein
  • MGC22233


Lipopolysaccharide-binding protein (LBP), a 58 kDa glycoprotein synthesized in hepatocytes, belongs to a family of lipid-binding proteins which includes bactericidal/permeability increasing protein (BPI), phospholipid ester transfer protein (PLTP), and cholesterol ester transfer protein (CETP). LBP binds to the lipid A portion of lipopolysaccharide (LPS) to facilitate the process of LPS monomerization, catalyze the binding of LPS monomers to CD14, and promote LPS-induced immune response. LBP is present at low concentrations in normal human serum and may increase up to 30-fold during the acute phase response. Studies indicate that LBP also acts catalytically in the transfer of LPS to HDL, thus accelerating LPS detoxification. In addition, LBP and soluble CD14 can also function in phospholipid transport.

  1. Hailman, E. et al. (1994) J. Exp. Med. 179:269.
  2. Jack, R.S. et al. (1997) Nature 389:742.
  3. Schumann, R.R. et al. (2000) Chem. Immunol. 74:42.

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Publications for LBP (870-LP/CF)(11)

We have publications tested in 2 confirmed species: Human, Chicken.

We have publications tested in 3 applications: Bioassay, Bioassay - Ctrl, EnzAct.

Filter By Application
Bioassay - Ctrl
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Showing Publications 1 - 10 of 11. Show All 11 Publications.
Publications using 870-LP/CF Applications Species
SJ Higgins, K Ceunynck, J Kellum, X Chen, X Gu, SA Chaudhry, S Schulman, TA Libermann, S Lu, NI Shapiro, DC Christiani, R Flaumenhaf, SM Parikh Tie2 protects the vasculature against thrombus formation in systemic inflammation J. Clin. Invest., 2018;0(0):. 2018 [PMID: 29360642] (Bioassay, Human) Bioassay Human
R Lehmann, MM Müller, TE Klassert, D Driesch, M Stock, A Heinrich, T Conrad, C Moore, UK Schier, R Guthke, H Slevogt Differential regulation of the transcriptomic and secretomic landscape of sensor and effector functions of human airway epithelial cells Mucosal Immunol, 2018;0(0):. 2018 [PMID: 29297499] (Bioassay, Human) Bioassay Human
PH Ding, RP Darveau, CY Wang, L Jin 3LPS-binding protein and its interactions with P. gingivalis LPS modulate pro-inflammatory response and Toll-like receptor signaling in human oral keratinocytes PLoS ONE, 2017;12(4):e0173223. 2017 [PMID: 28384159] (Bioassay, Human) Bioassay Human
B S Lashkari, DO Anumba Estradiol alters the immune-responsiveness of cervical epithelial cells stimulated with ligands of Toll-like receptors 2 and 4 PLoS ONE, 2017;12(3):e0173646. 2017 [PMID: 28296959] (Bioassay, Human) Bioassay Human
Annette C Wensink Granzymes A and K differentially potentiate LPS-induced cytokine response Cell Death Discov, 2016;2(0):16084. 2016 [PMID: 28028441] (Bioassay) Bioassay
Fang L, Xu Z, Wang G, Ji F, Mei C, Liu J, Wu G Directed evolution of an LBP/CD14 inhibitory peptide and its anti-endotoxin activity. PLoS ONE, 2014;9(7):e101406. 2014 [PMID: 25025695] (EnzAct, Human) EnzAct Human
Canault M, Ghalloussi D, Grosdidier C, Guinier M, Perret C, Chelghoum N, Germain M, Raslova H, Peiretti F, Morange P, Saut N, Pillois X, Nurden A, Cambien F, Pierres A, van den Berg T, Kuijpers T, Alessi M, Tregouet D Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding. J Exp Med, 2014;211(7):1349-62. 2014 [PMID: 24958846] (Bioassay, Human) Bioassay Human
Cordeiro, Cristian, Esmaili, Hamed, Ansah, George, Hincke, Maxwell Ovocalyxin-36 is a pattern recognition protein in chicken eggshell membranes. PLoS ONE, 2013;8(12):e84112. 2013 [PMID: 24391897] (Bioassay - Ctrl, Chicken) Bioassay - Ctrl Chicken
Malachowa N, Kobayashi S, Freedman B, Dorward D, DeLeo F Staphylococcus aureus leukotoxin GH promotes formation of neutrophil extracellular traps. J Immunol, 2013;191(12):6022-9. 2013 [PMID: 24190656] (Bioassay, Human) Bioassay Human
Gupta N, Li W, Willard B, Silverstein R, McIntyre T Proteasome proteolysis supports stimulated platelet function and thrombosis. Arterioscler Thromb Vasc Biol, 2014;34(1):160-8. 2014 [PMID: 24177323] (Bioassay, Human) Bioassay Human
Show All 11 Publications.

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Gene Symbol LBP