LBP Products

Description

The protein encoded by the LBP gene is involved in the acute-phase immunologic response to gram-negative bacterialinfections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Togetherwith bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that theencoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS fromcirculation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasmacholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). Finally, this gene is found onchromosome 20, immediately downstream of the BPI gene. (provided by RefSeq)

Bioinformatics

Entrez	16803 Mouse 3929 Human
Uniprot	AAH22256 Human AAH22256.1 Human NP_004130 Human P18428 Human
Product By Gene ID	3929
Alternate Names	lipopolysaccharide binding protein lipopolysaccharide-binding protein LPS-binding protein MGC22233

Research Areas for LBP

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Phospho-Specific