Recombinant Human IL-13 Protein, CF

Recombinant human IL-13 (213-ILB/CF) stimulates proliferation in the TF-1 human erythroleukemic cell line. The ED50 for this effect is 0.5-2.5 ng/mL.

• Reactivity: Hu
• Applications: Bioactivity
• Format: Carrier-Free

Recombinant Human IL-13 Protein, CF Summary

• Details of Functionality: Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. Kitamura, T. et al. (1989) J. Cell Physiol. 140:323. The ED₅₀ for this effect is 0.5-2.5 ng/mL.
• Source: E. coli-derived human IL-13 protein
  Gly21-Asn132
• Accession #: AAK53823
• N-terminal Sequence: Gly21
• Protein/Peptide Type: Recombinant Proteins
• Gene: IL13
• Purity: >95%, by SDS-PAGE under reducing conditions and visualized by silver stain
• Endotoxin Note: <0.01 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 12.3 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• SDS-PAGE: 9 kDa, reducing conditions

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS.
• Purity: >95%, by SDS-PAGE under reducing conditions and visualized by silver stain
• Reconstitution Instructions: Reconstitute at 100 μg/mL in PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human IL-13 Protein, CF

• ALRHMGC116789
• BHR1interleukin-13
• IL13
• IL-13
• IL-13MGC116788
• interleukin 13
• MGC116786
• NC30
• P600

Background

Interleukin-13 (IL-13) is a monomeric 17 kDa immunoregulatory cytokine that plays a key role in the pathogenesis of allergy, cancer, and tissue fibrosis. It is secreted by several helper T cell subsets, NK cells, mast cells, eosinophils, basophils, and visceral smooth muscle cells (1‑3). Mature human IL-13 shares approximately 58% amino acid sequence identity with mouse and rat IL-13. Despite the low homology, it exhibits cross‑species activity between human, mouse, and rat (4). IL-13 suppresses the production of proinflammatory cytokines and other cytotoxic substances by macrophages, fibroblasts, and endothelial cells. On B cells, it promotes cellular activation, immunoglobulin class switching to IgE, and the up‑regulation of CD23/Fc epsilon RII (1, 5). IL-13 binds with low affinity to the transmembrane IL-13 R alpha 1 which then forms a signaling complex with the transmembrane IL-4 R alpha (6‑8). This high affinity receptor complex also functions as the type 2 IL-4 receptor (6, 7). IL‑13 R alpha 2 inhibits responses to both IL-13 and IL-4. It binds IL-13 with high affinity (9, 10) and prevents IL-13 from signaling through the IL-13 R alpha 1/IL-4 R alpha complex (11, 12). It also blocks signaling through IL-4-occupied IL-13 R alpha 1/IL-4 R alpha receptor complexes (12, 13). In addition, IL-13-bound IL-13 R alpha 2 can directly promote tumor cell invasiveness and the development of tissue fibrosis (14‑16).

1. Saggini, A. et al. (2011) Int. J. Immunopathol. Pharmacol. 24:305.
2. Gallo, E. et al. (2012) Eur. J. Immunol. 42:2322.
3. Liang, H.E. et al. (2012) Nat. Immunol. 13:58.
4. Ruetten, H. and C. Thiemermann (1997) Shock 8:409.
5. McKenzie, A.N. et al. (1993) Proc. Natl. Acad. Sci. USA 90:3735.
6. Aman, M.J. et al. (1996) J. Biol. Chem. 271:29265.
7. Zurawski, S.M. et al. (1995) J. Biol. Chem. 270:13869.
8. Andrews, A.L. et al. (2002) J. Biol. Chem. 277:46073.
9. Chen, W. et al. (2009) J. Immunol. 183:7870.
10. Daines, M.O. et al. (2007) J. Allergy Clin. Immunol. 119:375.
11. Kasaian, M.T. et al. (2011) J. Immunol. 187:561.
12. Andrews, A.-L. et al. (2006) J. Allergy Clin. Immunol. 118:858.
13. Rahaman, S.O. et al. (2002) Cancer Res. 62:1103.
14. Fujisawa, T. et al. (2009) Cancer Res. 69:8678.
15. Fujisawa, T. et al. (2011) Int. J. Cancer 131:344.
16. Fichtner-Feigl, S. et al. (2006) Nat. Med. 12:99.

Publications for IL-13 (213-ILB/CF)(119)

Publications using 213-ILB/CF

• Ma, HY;Li, Q;Wong, WR;N'Diaye, EN;Caplazi, P;Bender, H;Huang, Z;Arlantico, A;Jeet, S;Wong, A;Emson, C;Brightbill, H;Tam, L;Newman, R;Roose-Girma, M;Sandoval, W;Ding, N; LOXL4, but not LOXL2, is the critical determinant of pathological collagen cross-linking and fibrosis in the lung Science advances 2023-05-26 [PMID: 37235663] (Bioassay, Human)
• L Lerouge, M Gries, A Chateau, J Daouk, F Lux, P Rocchi, J Cedervall, AK Olsson, O Tillement, C Frochot, S Acherar, N Thomas, M Barberi-He Targeting Glioblastoma-Associated Macrophages for Photodynamic Therapy Using AGuIX�-Design Nanoparticles Pharmaceutics, 2023-03-20;15(3):. 2023-03-20 [PMID: 36986856] (Bioassay, Human)
• K Long, J Liu, S Shen, M Thong, D Wang, N Chen Light-sheet laser speckle imaging for cilia motility assessment Computational and structural biotechnology journal, 2023-02-20;21(0):1661-1669. 2023-02-20 [PMID: 36874161] (Bioassay, Human)
• CW Ku, J Yang, HY Tan, JKY Chan, YH Lee Decreased Innate Migration of Pro-Inflammatory M1 Macrophages through the Mesothelial Membrane Is Affected by Ceramide Kinase and Ceramide 1-P International Journal of Molecular Sciences, 2022-12-15;23(24):. 2022-12-15 [PMID: 36555618] (Polarization, Human)
• R Akter, K Kim, HY Kwon, Y Kim, YW Eom, HM Cho, MY Cho EMR1/ADGRE1 Expression in Cancer Cells Upregulated by Tumor-Associated Macrophages Is Related to Poor Prognosis in Colorectal Cancer Biomedicines, 2022-12-02;10(12):. 2022-12-02 [PMID: 36551877] (Cell Culture, Human)
• FH Wang, CY Hsieh, CI Shen, CH Chuang, YH Chung, CC Kuo, KD Lee, CL Lin, HL Su Induction of type II collagen expression in M2 macrophages derived from peripheral blood mononuclear cells Scientific Reports, 2022-12-15;12(1):21663. 2022-12-15 [PMID: 36522405] (Bioassay, Human)
• A Mentxaka, J Gómez-Ambr, B Ramírez, A Rodríguez, S Becerril, G Neira, V Valentí, R Moncada, C Silva, X Unamuno, JA Cienfuegos, J Escalada, G Frühbeck, V Catalán Netrin-1 Promotes Visceral Adipose Tissue Inflammation in Obesity and Is Associated with Insulin Resistance Nutrients, 2022-10-18;14(20):. 2022-10-18 [PMID: 36297056] (Cell Culture, Human)
• F Real, A Zhu, B Huang, A Belmellat, A Sennepin, T Vogl, C Ransy, M Revol, R Arrigucci, A Lombès, J Roth, ML Gennaro, F Bouillaud, S Cristofari, M Bomsel S100A8-mediated metabolic adaptation controls HIV-1 persistence in macrophages in vivo Nature Communications, 2022-10-11;13(1):5956. 2022-10-11 [PMID: 36220814] (Bioassay, Human)
• H Cho, HY Kwon, A Sharma, SH Lee, X Liu, N Miyamoto, JJ Kim, SH Im, NY Kang, YT Chang Visualizing inflammation with an M1 macrophage selective probe via GLUT1 as the gating target Nature Communications, 2022-10-10;13(1):5974. 2022-10-10 [PMID: 36216803] (Bioassay, Human)
• P Pavlidis, A Tsakmaki, A Treveil, K Li, D Cozzetto, F Yang, U Niazi, BH Hayee, M Saqi, J Friedman, T Korcsmaros, G Bewick, N Powell Cytokine responsive networks in human colonic epithelial organoids unveil a molecular classification of inflammatory bowel disease Cell Reports, 2022-09-27;40(13):111439. 2022-09-27 [PMID: 36170836] (Bioassay, Human)
• V Catalán, P Domench, J Gómez-Ambr, B Ramírez, S Becerril, A Mentxaka, A Rodríguez, V Valentí, R Moncada, J Baixauli, C Silva, J Escalada, G Frühbeck Dermatopontin Influences the Development of Obesity-Associated Colon Cancer by Changes in the Expression of Extracellular Matrix Proteins International Journal of Molecular Sciences, 2022-08-17;23(16):. 2022-08-17 [PMID: 36012487] (Stimulation, Human)
• S Segarra, T Naiken, J Garnier, V Hamon, N Coussay, FX Bernard Enhanced In Vitro Expression of Filaggrin and Antimicrobial Peptides Following Application of Glycosaminoglycans and a Sphingomyelin-Rich Lipid Extract Oncogene, 2022-06-27;9(7):. 2022-06-27 [PMID: 35878340] (Bioassay, Human)
• M Modak, AK Mattes, D Reiss, W Skronska-W, R Langlois, N Sabarth, R Konopitzky, F Ramírez, K Lehr, T Mayr, D Kind, C Viollet, LK Swee, J Petschenka, KC El Kasmi, E Noessner, K Kitt, S Pflanz CD206+ tumor-associated macrophages cross-present tumor antigen and drive anti-tumor immunity JCI Insight, 2022-06-08;0(0):. 2022-06-08 [PMID: 35503656] (Bioassay, Human)
• H Han, Y Kim, H Mo, SH Choi, K Lee, YA Rim, JH Ju Preferential stimulation of melanocytes by M2 macrophages to produce melanin through vascular endothelial growth factor Scientific Reports, 2022-04-19;12(1):6416. 2022-04-19 [PMID: 35440608] (Bioassay, Human)
• Y Imoto, S Ueki, Y Kato, K Yoshida, T Morikawa, Y Kimura, M Kidoguchi, T Tsutsumiuc, K Koyama, N Adachi, Y Ito, K Ogi, M Sakashita, T Yamada, RP Schleimer, T Takabayash, S Fujieda Elevated Serum Leptin Levels in Patients With Eosinophilic Chronic Rhinosinusitis Frontiers in Pharmacology, 2022-01-03;12(0):793607. 2022-01-03 [PMID: 35046816] (Bioassay, Human)
• A Kielczewsk, I D'Angelo, MS Amador, T Wang, A Sudom, X Min, P Rathanaswa, C Pigott, IN Foltz Development of a potent high-affinity human therapeutic antibody via novel application of Recombination Signal Sequence (RSS)-based Affinity Maturation The Journal of Biological Chemistry, 2021-12-29;0(0):101533. 2021-12-29 [PMID: 34973336] (Bioassay, Human)
• S Kim, HW Kim, SH Chang, KH Leem, HJ Park Bee Venom Prevents Mucin 5AC Production through Inhibition of AKT and SPDEF Activation in Airway Epithelia Cells Toxins, 2021-11-01;13(11):. 2021-11-01 [PMID: 34822557] (Bioassay, Human)
• E Kim, H Um, J Park, JW Jung, JE Kim, H Lee, EA Shin, Y Pinanga, H Lee, SH Nam, JW Lee TM4SF5-dependent crosstalk between hepatocytes and macrophages to reprogram the inflammatory environment Cell Reports, 2021-11-16;37(7):110018. 2021-11-16 [PMID: 34788612] (Bioassay, Human)
• L Xiao, Y Shiwaku, R Hamai, K Tsuchiya, K Sasaki, O Suzuki Macrophage Polarization Related to Crystal Phases of Calcium Phosphate Biomaterials International Journal of Molecular Sciences, 2021-10-19;22(20):. 2021-10-19 [PMID: 34681912] (Polarization, Human)
• A Kuzumi, A Yoshizaki, KM Matsuda, H Kotani, Y Norimatsu, M Fukayama, S Ebata, T Fukasawa, A Yoshizaki-, Y Asano, K Morikawa, Y Kazoe, K Mawatari, T Kitamori, S Sato Interleukin-31 promotes fibrosis and T helper 2 polarization in systemic sclerosis Nature Communications, 2021-10-12;12(1):5947. 2021-10-12 [PMID: 34642338] (Bioassay, Human)
• CN Noto, SG Hoft, KA Bockerstet, NM Jackson, EL Ford, LS Vest, RJ DiPaolo IL-13 acts directly on gastric epithelial cells to promote metaplasia development during chronic gastritis Cellular and Molecular Gastroenterology and Hepatology, 2021-09-26;0(0):. 2021-09-26 [PMID: 34587523] (Bioassay, Mouse)
• S Shao, J Chen, WR Swindell, LC Tsoi, X Xing, F Ma, R Uppala, MK Sarkar, O Plazyo, AC Billi, R Wasikowski, KM Smith, P Honore, VE Scott, E Maverakis, JM Kahlenberg, G Wang, NL Ward, PW Harms, JE Gudjonsson Phospholipase A2 enzymes represent a shared pathogenic pathway in psoriasis and pityriasis rubra pilaris JCI Insight, 2021-10-22;0(0):. 2021-10-22 [PMID: 34491907] (Bioassay, Human)
• I Gómez de S, P Ahechu, J Gómez-Ambr, A Rodríguez, B Ramírez, S Becerril, X Unamuno, A Mentxaka, J Baixauli, V Valentí, R Moncada, C Silva, G Frühbeck, V Catalán Decreased Levels of Microfibril-Associated Glycoprotein (MAGP)-1 in Patients with Colon Cancer and Obesity Are Associated with Changes in Extracellular Matrix Remodelling International Journal of Molecular Sciences, 2021-08-06;22(16):. 2021-08-06 [PMID: 34445187] (Bioassay, Human)
• B Jakiela, A Rebane, J Soja, S Bazan-Soch, A Laanesoo, H Plutecka, M Surmiak, M Sanak, K Sladek, G Bochenek Remodeling of bronchial epithelium caused by asthmatic inflammation affects its response to rhinovirus infection Scientific Reports, 2021-06-17;11(1):12821. 2021-06-17 [PMID: 34140575] (Cell Culture, Human)
• X Huang, T Oshima, T Tomita, H Fukui, H Miwa Butyrate Alleviates Cytokine-Induced Barrier Dysfunction by Modifying Claudin-2 Levels Biology, 2021-03-09;10(3):. 2021-03-09 [PMID: 33803334] (Bioassay, Human)
• LB Richards, M Li, G Folkerts, PAJ Henricks, J Garssen, BCAM van Esch Butyrate and Propionate Restore the Cytokine and House Dust Mite Compromised Barrier Function of Human Bronchial Airway Epithelial Cells International Journal of Molecular Sciences, 2020-12-23;22(1):. 2020-12-23 [PMID: 33374733] (Bioassay, Human)
• T Wang, P Wang, D Chen, Z Xu, L Yang circARRDC3 contributes to interleukin?13?induced inflammatory cytokine and mucus production in nasal epithelial cells via the miR?375/KLF4 axis Molecular Medicine Reports, 2020-12-14;23(2):. 2020-12-14 [PMID: 33313951] (Cell Culture, Human)
• I Hwang, JW Kim, K Ylaya, EJ Chung, H Kitano, C Perry, J Hanaoka, J Fukuoka, JY Chung, SM Hewitt Tumor-associated macrophage, angiogenesis and lymphangiogenesis markers predict prognosis of non-small cell lung cancer patients J Transl Med, 2020-11-23;18(1):443. 2020-11-23 [PMID: 33228719] (Cell Culture, Human)
• HK Min, JY Won, BM Kim, KA Lee, SJ Lee, SH Lee, HR Kim, KW Kim Interleukin (IL)-25 suppresses IL-22-induced osteoclastogenesis in rheumatoid arthritis via STAT3 and p38 MAPK/I&amp;kappaB&amp;alpha pathway Arthritis Research & Therapy, 2020-09-23;22(1):222. 2020-09-23 [PMID: 32972460] (Human)
• X Yang, Q Guo, T Feng, Q Lu, L Ge, J Pan, K Bi, L Qiao, L Tian, T Xie, C Yao, G Song, L Wang IL13Ralpha1 protects against rheumatoid arthritis by combating the apoptotic resistance of fibroblast-like synoviocytes Arthritis Res. Ther., 2020-08-08;22(1):184. 2020-08-08 [PMID: 32771038] (Bioassay, Human)
• KJ Gregory, SM Morin, A Kubosiak, J Ser-Dolans, B Schalet, DJ Jerry, SS Schneider The use of patient-derived breast tissue explants to study macrophage polarization and the effects of environmental chemical exposure Immunol. Cell Biol., 2020-09-09;0(0):. 2020-09-09 [PMID: 32713010] (Cell Culture, Human)
• PF Duffney, HH Kim, NA Porter, I Jaspers Ozone-derived oxysterols impair lung macrophage phagocytosis via adduction of some phagocytosis receptors J. Biol. Chem., 2020-07-20;0(0):. 2020-07-20 [PMID: 32690608] (Cell Culture, Human)
• ND Jackson, JL Everman, M Chioccioli, L Feriani, KC Goldfarbmu, SP Sajuthi, CL Rios, R Powell, M Armstrong, J Gomez, C Michel, C Eng, SS Oh, J Rodriguez-, P Cicuta, N Reisdorph, EG Burchard, MA Seibold Single-Cell and Population Transcriptomics Reveal Pan-epithelial Remodeling in Type 2-High Asthma Cell Rep, 2020-07-07;32(1):107872. 2020-07-07 [PMID: 32640237] (Cell Culture, Human)
• J Yan, SP Pandey, BJ Barnes, JR Turner, C Abraham T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation Cell Rep, 2020-06-30;31(13):107820. 2020-06-30 [PMID: 32610123] (Bioassay, Human)
• Y Kubo, K Ishikawa, K Mori, Y Kobayashi, T Nakama, M Arima, S Nakao, T Hisatomi, M Haruta, KH Sonoda, S Yoshida Periostin and tenascin-C interaction promotes angiogenesis in ischemic proliferative retinopathy Sci Rep, 2020-06-09;10(1):9299. 2020-06-09 [PMID: 32518264] (Bioassay, Human)
• RA Lu, AA Zeki, S Ram-Mohan, N Nguyen, Y Bai, K Chmiel, S Pecic, X Ai, R Krishnan, CC Ghosh Inhibiting Airway Smooth Muscle Contraction Using Pitavastatin: A Role for the Mevalonate Pathway in Regulating Cytoskeletal Proteins Front Pharmacol, 2020-05-06;11(0):469. 2020-05-06 [PMID: 32435188] (Cell Culture, Human)
• YD Kim, SM Park, HC Ha, AR Lee, H Won, H Cha, S Cho, JM Cho HDAC Inhibitor, CG-745, Enhances the Anti-Cancer Effect of Anti-PD-1 Immune Checkpoint Inhibitor by Modulation of the Immune Microenvironment J Cancer, 2020-04-06;11(14):4059-4072. 2020-04-06 [PMID: 32368288] (Bioassay, Human)
• X Unamuno, J Gómez-Ambr, B Ramírez, A Rodríguez, S Becerril, V Valentí, R Moncada, C Silva, J Salvador, G Frühbeck, V Catalán Dermatopontin, A Novel Adipokine Promoting Adipose Tissue Extracellular Matrix Remodelling and Inflammation in Obesity J Clin Med, 2020-04-09;9(4):. 2020-04-09 [PMID: 32283761] (Cell Culture, Human)
• YJ Chen, CY Tsai, YM Cheng, SW Nieh, TK Yeh, CP Chen, MH Wang, LH Chou, TY Chiu, L Liu, C Ho, CT Chen, TW Liu Impacts of Intralipid on Nanodrug Abraxane Therapy and on the Innate Immune System Sci Rep, 2020-02-18;10(1):2838. 2020-02-18 [PMID: 32071352] (Cell Culture, Human)
• YT Chang, HY Peng, CM Hu, SC Huang, SC Tien, YM Jeng Pancreatic cancer-derived small extracellular vesical Ezrin regulates macrophage polarization and promotes metastasis Am J Cancer Res, 2020-01-01;10(1):12-37. 2020-01-01 [PMID: 32064151] (Bioassay, Human)
• V Delprat, C Tellier, C Demazy, M Raes, O Feron, C Michiels Cycling hypoxia promotes a pro-inflammatory phenotype in macrophages via JNK/p65 signaling pathway Sci Rep, 2020-01-21;10(1):882. 2020-01-21 [PMID: 31964911] (Bioassay, Human)
• G Liu, L Yin, X Ouyang, K Zeng, Y Xiao, Y Li M2 Macrophages Promote HCC Cells Invasion and Migration via miR-149-5p/MMP9 Signaling J Cancer, 2020-01-01;11(5):1277-1287. 2020-01-01 [PMID: 31956374] (Cell Culture, Human)
• SC Lee, MS Tang, AV Easton, JC Devlin, LL Chua, I Cho, FM Moy, TF Khang, YAL Lim, P Loke Linking the effects of helminth infection, diet and the gut microbiota with human whole-blood signatures PLoS Pathog., 2019-12-16;15(12):e1008066. 2019-12-16 [PMID: 31841569] (Cell Culture, Human)
• SD Pauls, LA Rodway, T Winter, CG Taylor, P Zahradka, HM Aukema Alpha-linolenic acid enhances the phagocytic and secretory functions of alternatively activated macrophages in part via changes to the oxylipin profile Int. J. Biochem. Cell Biol., 2019-12-04;119(0):105662. 2019-12-04 [PMID: 31811954] (Bioassay, Human)
• N Berges, MS Nawaz, T Børresdatt, L Hagen, M Bjørås, JK Laerdahl, I Alseth Complex alternative splicing of human Endonuclease V mRNA, but evidence for only a single protein isoform PLoS ONE, 2019-11-08;14(11):e0225081. 2019-11-08 [PMID: 31703097] (Cell Culture, Human)
• X Unamuno, J Gómez-Ambr, B Ramírez, A Rodríguez, S Becerril, V Valentí, R Moncada, C Silva, J Salvador, G Frühbeck, V Catalán NLRP3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling Cell. Mol. Immunol., 2019-09-24;0(0):. 2019-09-24 [PMID: 31551515] (Bioassay, Human)
• Y Wu, MM Konaté, J Lu, H Makhlouf, R Chuaqui, S Antony, JL Meitzler, MJ Difilippan, H Liu, A Juhasz, G Jiang, I Dahan, K Roy, JH Doroshow IL-4 and IL-17A Cooperatively Promote Hydrogen Peroxide Production, Oxidative DNA Damage, and Upregulation of Dual Oxidase 2 in Human Colon and Pancreatic Cancer Cells J. Immunol., 2019-09-23;0(0):. 2019-09-23 [PMID: 31548328] (Bioassay, Human)
• S Sugihara, S Sugimoto, K Tachibana, M Kobashi, H Nomura, T Miyake, Y Hirai, O Yamasaki, S Morizane TNF-α and IL-17A induce the expression of lympho-epithelial Kazal-type inhibitor in epidermal keratinocytes J. Dermatol. Sci., 2019-08-21;0(0):. 2019-08-21 [PMID: 31501002] (Cell Culture, Human)
• KJ Pahk, CH Shin, IY Bae, Y Yang, SH Kim, K Pahk, H Kim, SJ Oh Boiling Histotripsy-induced Partial Mechanical Ablation Modulates Tumour Microenvironment by Promoting Immunogenic Cell Death of Cancers Sci Rep, 2019-06-21;9(1):9050. 2019-06-21 [PMID: 31227775] (Bioassay, Human)
• X Qin, M Liu, S Zhang, C Wang, T Zhang The role of IL-36? and its regulation in eosinophilic inflammation in allergic rhinitis Cytokine, 2019-03-01;117(0):84-90. 2019-03-01 [PMID: 30831444] (Bioassay, Human)
• G Cantero-Re, CM Butnaru, N Brouwers, S Mitrovic, MA Valverde, V Malhotra Sodium channel TRPM4 and sodium/calcium exchangers (NCX) cooperate in the control of Ca2+-induced mucin secretion from goblet cells J. Biol. Chem., 2018-11-27;0(0):. 2018-11-27 [PMID: 30482841] (Bioassay, Human)
• L She, Y Qin, J Wang, C Liu, G Zhu, G Li, M Wei, C Chen, G Liu, D Zhang, X Chen, Y Wang, Y Qiu, Y Tian, X Zhang, Y Liu, D Huang Tumor-associated macrophages derived CCL18 promotes metastasis in squamous cell carcinoma of the head and neck Cancer Cell Int., 2018-08-28;18(0):120. 2018-08-28 [PMID: 30181713] (Bioassay, Human)
• SR Kim, JM Lewis, BM Cyrenne, PF Monico, FN Mirza, KR Carlson, FM Foss, M Girardi BET inhibition in advanced cutaneous T cell lymphoma is synergistically potentiated by BCL2 inhibition or HDAC inhibition Oncotarget, 2018-06-26;9(49):29193-29207. 2018-06-26 [PMID: 30018745] (Bioassay, Human)
• G Genard, AC Wera, C Huart, B Le Calve, S Penninckx, A Fattacciol, T Tabarrant, C Demazy, N Ninane, AC Heuskin, S Lucas, C Michiels Proton irradiation orchestrates macrophage reprogramming through NF?B signaling Cell Death Dis, 2018-06-27;9(7):728. 2018-06-27 [PMID: 29950610] (Bioassay, Human)
• I Pop?na, A ?bols, L Saul?te, K Pleiko, E Zandberga, K J?kabsons, E Endzeli?š, A Llorente, A Lin?, U Rieksti?a Effect of colorectal cancer-derived extracellular vesicles on the immunophenotype and cytokine secretion profile of monocytes and macrophages Cell Commun. Signal, 2018-04-24;16(1):17. 2018-04-24 [PMID: 29690889] (Differentiation, Differentiation, Human)
• Y Ito, R Al Mubarak, N Roberts, K Correll, W Janssen, J Finigan, R Mishra, HW Chu IL-13 induces periostin and eotaxin expression in human primary alveolar epithelial cells: Comparison with paired airway epithelial cells PLoS ONE, 2018-04-19;13(4):e0196256. 2018-04-19 [PMID: 29672593] (Bioassay, Human)
• R da Silva A, AK Mehta, L Madge, J Tocker, M Croft TNFSF14 (LIGHT) Exhibits Inflammatory Activities in Lung Fibroblasts Complementary to IL-13 and TGF-β Front Immunol, 2018-03-19;9(0):576. 2018-03-19 [PMID: 29616048] (Cell Culture, Human)
• EY Huang, JC Chang, HH Chen, CY Hsu, HC Hsu, KL Wu Carcinoembryonic antigen as a marker of radioresistance in colorectal cancer: a potential role of macrophages BMC Cancer, 2018-03-27;18(1):321. 2018-03-27 [PMID: 29580202] (Bioassay, Human)
• E Berdyshev, E Goleva, I Bronova, N Dyjack, C Rios, J Jung, P Taylor, M Jeong, CF Hall, BN Richers, KA Norquest, T Zheng, MA Seibold, DY Leung Lipid abnormalities in atopic skin are driven by type 2 cytokines JCI Insight, 2018-02-22;3(4):. 2018-02-22 [PMID: 29467325] (Bioassay, Human)
• M Gwiggner, RT Martinez-N, SR Whiteoak, VP Bondanese, A Claridge, JE Collins, JRF Cummings, T Sanchez-El MicroRNA-31 and MicroRNA-155 Are Overexpressed in Ulcerative Colitis and Regulate IL-13 Signaling by Targeting Interleukin 13 Receptor ?-1 Genes (Basel), 2018-02-13;9(2):. 2018-02-13 [PMID: 29438285] (Bioassay, Human)
• R Bruen, S Curley, S Kajani, D Crean, ME O'Reilly, MB Lucitt, CG Godson, FC McGillicud, O Belton Liraglutide dictates macrophage phenotype in apolipoprotein E null mice during early atherosclerosis Cardiovasc Diabetol, 2017-11-06;16(1):143. 2017-11-06 [PMID: 29110715] (Bioassay, Human)
• Y Wang, JB Mumm, R Herbst, R Kolbeck, Y Wang IL-22 Increases Permeability of Intestinal Epithelial Tight Junctions by Enhancing Claudin-2 Expression J. Immunol., 2017-09-22;0(0):. 2017-09-22 [PMID: 28939759] (Bioassay, Human)
• J Zeitvogel, N Jokmin, S Rieker, I Klug, C Brandenber, T Werfel GATA3 regulates FLG and FLG2 expression in human primary keratinocytes Sci Rep, 2017-09-19;7(1):11847. 2017-09-19 [PMID: 28928464] (Bioassay, Human)
• S Bartel, N Schulz, F Alessandri, AC Schamberge, P Pagel, FJ Theis, K Milger, E Noessner, SM Stick, A Kicic, O Eickelberg, RJ Freishtat, S Krauss-Ets Pulmonary microRNA profiles identify involvement of Creb1 and Sec14l3 in bronchial epithelial changes in allergic asthma Sci Rep, 2017-04-06;7(0):46026. 2017-04-06 [PMID: 28383034] (Bioassay, Human)
• T Nakama, S Yoshida, K Ishikawa, Y Kubo, Y Kobayashi, Y Zhou, S Nakao, T Hisatomi, Y Ikeda, K Takao, K Yoshikawa, A Matsuda, J Ono, S Ohta, K Izuhara, A Kudo, KH Sonoda, T Ishibashi Therapeutic Effect of Novel Single-Stranded RNAi Agent Targeting Periostin in Eyes with Retinal Neovascularization Mol Ther Nucleic Acids, 2017-02-09;6(0):279-289. 2017-02-09 [PMID: 28325294] (Bioassay, Human)
• BF Wang, PP Cao, ZC Wang, ZY Li, ZZ Wang, J Ma, B Liao, YK Deng, XB Long, K Xu, H Wang, H Wang, M Zeng, X Lu, Z Liu Interferon-? induced insufficient autophagy contributes to p62-dependent apoptosis of epithelial cells in chronic rhinosinusitis with nasal polyps Allergy, 2017-04-04;0(0):. 2017-04-04 [PMID: 28258963] (Bioassay, Human)
• J Ji, A Hedelin, M Malml”f, V Kessler, G Seisenbaev, P Gerde, L Palmberg Development of Combining of Human Bronchial Mucosa Models with XposeALI? for Exposure of Air Pollution Nanoparticles PLoS ONE, 2017-01-20;12(1):e0170428. 2017-01-20 [PMID: 28107509] (Bioassay, Human)
• B Popovic Structural Characterisation Reveals Mechanism of IL-13 Neutralising Monoclonal Antibody Tralokinumab as Inhibition of Binding to IL-13R?1 and IL-13R?2 J. Mol. Biol, 2016-12-09;0(0):. 2016-12-09 [PMID: 27956146] (Bioassay)
• Leonardo J Galvão-Lim Classical and alternative macrophages have impaired function during acute and chronic HIV-1 infection Braz J Infect Dis, 2016-11-29;0(0):. 2016-11-29 [PMID: 27912071] (Bioassay, Human)
• Nathalie Castex-Riz Anti-inflammatory and immunomodulatory effects of Aquaphilus dolomiae extract on in vitro models Clin Cosmet Investig Dermatol, 2016-11-10;9(0):421-434. 2016-11-10 [PMID: 27877060] (Bioassay, Human)
• Thymic stromal chemokine TSLP acts through Th2 cytokine production to induce cutaneous T cell lymphoma Cancer Res, 2016-09-06;0(0):. 2016-09-06 [PMID: 27634769] (Bioassay, Human)
• Victoria Catalán Increased Interleukin-32 Levels in Obesity Promote Adipose Tissue Inflammation and Extracellular Matrix Remodeling: Effect of Weight Loss Diabetes, 2016-09-14;65(12):3636-3648. 2016-09-14 [PMID: 27630206] (Bioassay, Human)
• Edaire Cheng JAK-STAT6 Pathway Inhibitors Block Eotaxin-3 Secretion by Epithelial Cells and Fibroblasts from Esophageal Eosinophilia Patients: Promising Agents to Improve Inflammation and Prevent Fibrosis in EoE PLoS ONE, 2016-06-16;11(6):e0157376. 2016-06-16 [PMID: 27310888] (Bioassay, Human)
• S O'Reilly, M Ciechomska, N Fullard, S Przyborski, JM van Laar IL-13 mediates collagen deposition via STAT6 and microRNA-135b: a role for epigenetics Sci Rep, 2016-04-26;6(0):25066. 2016-04-26 [PMID: 27113293] (Bioassay, Human)
• Knight J, Mak G, Shaw J, Porter P, McDermott C, Roberts L, You R, Yuan X, Millien V, Qian Y, Song L, Frazier V, Kim C, Kim J, Bond R, Milner J, Zhang Y, Mandal P, Luong A, Kheradmand F, McMurray J, Corry D Long-Acting Beta Agonists Enhance Allergic Airway Disease. PLoS ONE, 2015-11-25;10(11):e0142212. 2015-11-25 [PMID: 26605551] (Bioassay, Human)
• Shipkowski K, Taylor A, Thompson E, Glista-Baker E, Sayers B, Messenger Z, Bauer R, Jaspers I, Bonner J An Allergic Lung Microenvironment Suppresses Carbon Nanotube-Induced Inflammasome Activation via STAT6-Dependent Inhibition of Caspase-1. PLoS ONE, 2015-06-19;10(6):e0128888. 2015-06-19 [PMID: 26091108] (Bioassay, Human)
• Lee J, Komatsu K, Lee B, Miyata M, O'Neill Bohn A, Xu H, Yan C, Li J Vinpocetine inhibits Streptococcus pneumoniae-induced upregulation of mucin MUC5AC expression via induction of MKP-1 phosphatase in the pathogenesis of otitis media. J Immunol, 2015-05-13;194(12):5990-8. 2015-05-13 [PMID: 25972475] (Bioassay, Human)
• Yao , Xiujuan, Wang , Wei, Li , Yan, Huang , Ping, Zhang , Qian, Wang , Jingjing, Wang , Wen, Lv , Zhe, An , Yunqing, Qin , Jianguo, Corrigan , Chris J, Huang , Kewu, Sun , Yongchan, Ying , Sun IL-25 induces airways angiogenesis and expression of multiple angiogenic factors in a murine asthma model. Respir Res, 2015-03-18;16(0):39. 2015-03-18 [PMID: 25889697] (Bioassay, Human)
• Kwofie K, Scott M, Rodrigues R, Guerette J, Radford K, Nair P, Richards C Regulation of IL-17A responses in human airway smooth muscle cells by Oncostatin M. Respir Res, 2015-02-07;16(0):14. 2015-02-07 [PMID: 25849622] (Bioassay, Human)
• Xu J, Singhera G, Dorscheid D Expression of surfactant protein D in airways of asthmatics and interleukin-13 modulation of surfactant protein D in human models of airway epithelium. Respir Res, 2015-02-15;16(0):26. 2015-02-15 [PMID: 25848896] (Neutralization, Human)
• Zafra M, Canas J, Mazzeo C, Gamez C, Sanz V, Fernandez-Nieto M, Quirce S, Barranco P, Ruiz-Hornillos J, Sastre J, del Pozo V SOCS3 silencing attenuates eosinophil functions in asthma patients. Int J Mol Sci, 2015-03-10;16(3):5434-51. 2015-03-10 [PMID: 25764157] (Bioassay, Human)
• Herova M, Schmid M, Gemperle C, Hersberger M ChemR23, the receptor for chemerin and resolvin E1, is expressed and functional on M1 but not on M2 macrophages. J Immunol, 2015-01-30;194(5):2330-7. 2015-01-30 [PMID: 25637017] (Bioassay, Human)
• Xie M, Mustovich A, Jiang Y, Trudeau J, Ray A, Ray P, Hu H, Holguin F, Freeman B, Wenzel S IL-27 and type 2 immunity in asthmatic patients: association with severity, CXCL9, and signal transducer and activator of transcription signaling. J Allergy Clin Immunol, 2014-10-11;135(2):386-94. 2014-10-11 [PMID: 25312760] (Bioassay, Human)
• Iwaisako K, Jiang C, Zhang M, Cong M, Moore-Morris T, Park T, Liu X, Xu J, Wang P, Paik Y, Meng F, Asagiri M, Murray L, Hofmann A, Iida T, Glass C, Brenner D, Kisseleva T Origin of myofibroblasts in the fibrotic liver in mice. Proc Natl Acad Sci U S A, 2014-07-29;111(32):E3297-305. 2014-07-29 [PMID: 25074909] (Bioassay, Human)
• Park , Jason Y, Zhang , Xi, Nguyen , Nathalie, Souza , Rhonda F, Spechler , Stuart J, Cheng , Edaire Proton pump inhibitors decrease eotaxin-3 expression in the proximal esophagus of children with esophageal eosinophilia. PLoS ONE, 2014-07-02;9(7):e101391. 2014-07-02 [PMID: 24988451] (Bioassay, Human)
• Melum G, Farkas L, Scheel C, Van Dieren B, Gran E, Liu Y, Johansen F, Jahnsen F, Baekkevold E A thymic stromal lymphopoietin-responsive dendritic cell subset mediates allergic responses in the upper airway mucosa. J Allergy Clin Immunol, 2014-06-21;134(3):613-621.e7. 2014-06-21 [PMID: 24958565] (Bioassay, Human)
• Voraphani N, Gladwin M, Contreras A, Kaminski N, Tedrow J, Milosevic J, Bleecker E, Meyers D, Ray A, Ray P, Erzurum S, Busse W, Zhao J, Trudeau J, Wenzel S An airway epithelial iNOS-DUOX2-thyroid peroxidase metabolome drives Th1/Th2 nitrative stress in human severe asthma. Mucosal Immunol, 2014-02-12;7(5):1175-85. 2014-02-12 [PMID: 24518246] (Bioassay, Human)
• Tanabe T, Shimokawaji T, Kanoh S, Rubin B IL-33 stimulates CXCL8/IL-8 secretion in goblet cells but not normally differentiated airway cells. Clin Exp Allergy, 2014-04-01;44(4):540-52. 2014-04-01 [PMID: 24479526] (Bioassay, Human)
• Ahmad T, Mukherjee S, Pattnaik B, Kumar M, Singh S, Kumar M, Rehman R, Tiwari B, Jha K, Barhanpurkar A, Wani M, Roy S, Mabalirajan U, Ghosh B, Agrawal A Miro1 regulates intercellular mitochondrial transport &amp; enhances mesenchymal stem cell rescue efficacy. EMBO J, 2014-01-15;33(9):994-1010. 2014-01-15 [PMID: 24431222] (Bioassay, Human)
• Biancheri P, Di Sabatino A, Ammoscato F, Facciotti F, Caprioli F, Curciarello R, Hoque S, Ghanbari A, Joe-Njoku I, Giuffrida P, Rovedatti L, Geginat J, Corazza G, MacDonald T Absence of a role for interleukin-13 in inflammatory bowel disease. Eur J Immunol, 2014-02-01;44(2):370-85. 2014-02-01 [PMID: 24338958] (Bioassay, Human)
• Engstrom A, Erlandsson A, Delbro D, Wijkander J Conditioned media from macrophages of M1, but not M2 phenotype, inhibit the proliferation of the colon cancer cell lines HT-29 and CACO-2. Int J Oncol, 2013-12-02;44(2):385-92. 2013-12-02 [PMID: 24296981] (Bioassay, Human)
• Otsuka A, Doi H, Egawa G, Maekawa A, Fujita T, Nakamizo S, Nakashima C, Nakajima S, Watanabe T, Miyachi Y, Narumiya S, Kabashima K Possible new therapeutic strategy to regulate atopic dermatitis through upregulating filaggrin expression. J Allergy Clin Immunol, 2013-09-20;133(1):139-46.e1-10. 2013-09-20 [PMID: 24055295] (Bioassay, Human)
• Mabalirajan U, Rehman R, Ahmad T, Kumar S, Leishangthem G, Singh S, Dinda A, Biswal S, Agrawal A, Ghosh B 12/15-lipoxygenase expressed in non-epithelial cells causes airway epithelial injury in asthma. Sci Rep, 2013-01-01;3(0):1540. 2013-01-01 [PMID: 23528921] (Bioassay, Human)
• Pellerin L, Henry J, Hsu C, Balica S, Jean-Decoster C, Mechin M, Hansmann B, Rodriguez E, Weindinger S, Schmitt A, Serre G, Paul C, Simon M Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin. J Allergy Clin Immunol, 2013-02-10;131(4):1094-102. 2013-02-10 [PMID: 23403047] (Bioassay, Human)
• Gemperle C, Schmid M, Herova M, Marti-Jaun J, Wuest S, Loretz C, Hersberger M Regulation of the formyl peptide receptor 1 (FPR1) gene in primary human macrophages. PLoS ONE, 2012-11-21;7(11):e50195. 2012-11-21 [PMID: 23185575] (Bioassay, Human)
• Corvaisier M, Delneste Y, Jeanvoine H, Preisser L, Blanchard S, Garo E, Hoppe E, Barre B, Audran M, Bouvard B, Saint-Andre J, Jeannin P IL-26 Is Overexpressed in Rheumatoid Arthritis and Induces Proinflammatory Cytokine Production and Th17 Cell Generation. PLoS Biol, 2012-09-25;10(9):e1001395. 2012-09-25 [PMID: 23055831] (Bioassay, Human)
• Zhang J, Shan L, Koussih L, Redhu NS, Halayko AJ, Chakir J, Gounni AS Pentraxin 3 (PTX3) expression in allergic asthmatic airways: role in airway smooth muscle migration and chemokine production. PLoS ONE, 2012-04-18;7(4):e34965. 2012-04-18 [PMID: 22529962] (Bioassay, Human)
• Joubert P, Lajoie-Kadoch S, Wellemans V, Létuvé S, Tulic MK, Halayko AJ, Hamid Q Expression and regulation of CCL15 by human airway smooth muscle cells. Clin. Exp. Allergy, 2011-11-09;42(1):85-94. 2011-11-09 [PMID: 22092970] (Bioassay, Human)
• Epigenetic modulation enhances the therapeutic effect of anti-IL-13R alpha2 antibody in human mesothelioma xenografts. Clin. Cancer Res., 2011-02-28;17(9):2819-29. 2011-02-28 [PMID: 21357681] (Bioassay, Human)
• Le TA, Takai T, Kinoshita H, Suto H, Ikeda S, Okumura K, Ogawa H Inhibition of double-stranded RNA-induced TSLP in human keratinocytes by glucocorticoids. Allergy, 2009-03-27;64(8):1231-2. 2009-03-27 [PMID: 19416141] (Bioassay, Human)
• Ma P, Bian F, Wang Z, Zheng X, Chotikavanich S, Pflugfelder SC, Li DQ Human corneal epithelium-derived thymic stromal lymphopoietin links the innate and adaptive immune responses via TLRs and Th2 cytokines. Invest. Ophthalmol. Vis. Sci., 2009-01-17;50(6):2702-9. 2009-01-17 [PMID: 19151401] (Bioassay, Human)
• Eyerich K, Pennino D, Scarponi C, Foerster S, Nasorri F, Behrendt H, Ring J, Traidl-Hoffmann C, Albanesi C, Cavani A IL-17 in atopic eczema: linking allergen-specific adaptive and microbial-triggered innate immune response. J. Allergy Clin. Immunol., 2008-12-03;123(1):59-66.e4. 2008-12-03 [PMID: 19056110] (Bioassay, Human)
• Mancino A, Schioppa T, Larghi P, Pasqualini F, Nebuloni M, Chen IH, Sozzani S, Austyn JM, Mantovani A, Sica A Divergent effects of hypoxia on dendritic cell functions. Blood, 2008-08-11;112(9):3723-34. 2008-08-11 [PMID: 18694997] (Bioassay, Human)
• Kato A, Peters A, Suh L, Carter R, Harris KE, Chandra R, Conley D, Grammer LC, Kern R, Schleimer RP Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps. J. Allergy Clin. Immunol., 2008-04-14;121(6):1385-92, 1392. 2008-04-14 [PMID: 18410958] (Bioassay, Human)
• Miller R, Sadhukhan R, Wu C Development of an in vitro potency bioassay for therapeutic IL-13 antagonists: the A-549 cell bioassay. J. Immunol. Methods, 2008-03-07;334(1):134-41. 2008-03-07 [PMID: 18355834] (Bioassay, Human)
• Liu TY, Uemura Y, Suzuki M, Narita Y, Hirata S, Ohyama H, Ishihara O, Matsushita S Distinct subsets of human invariant NKT cells differentially regulate T helper responses via dendritic cells. Eur. J. Immunol., 2008-04-01;38(4):1012-23. 2008-04-01 [PMID: 18350544] (Bioassay, Human)
• Joubert P, Lajoie-Kadoch S, Welman M, Dragon S, Letuvee S, Tolloczko B, Halayko AJ, Gounni AS, Maghni K, Hamid Q Expression and regulation of CCR1 by airway smooth muscle cells in asthma. J. Immunol., 2008-01-15;180(2):1268-75. 2008-01-15 [PMID: 18178867] (Bioassay, Human)
• Kato A, Favoreto S, Avila PC, Schleimer RP TLR3- and Th2 cytokine-dependent production of thymic stromal lymphopoietin in human airway epithelial cells. J. Immunol., 2007-07-15;179(2):1080-7. 2007-07-15 [PMID: 17617600] (Bioassay, Human)
• Beisswenger C, Kandler K, Hess C, Garn H, Felgentreff K, Wegmann M, Renz H, Vogelmeier C, Bals R Allergic airway inflammation inhibits pulmonary antibacterial host defense. J. Immunol., 2006-08-01;177(3):1833-7. 2006-08-01 [PMID: 16849494] (Bioassay, Human)
• Howell MD, Gallo RL, Boguniewicz M, Jones JF, Wong C, Streib JE, Leung DY Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus. Immunity, 2006-03-01;24(3):341-8. 2006-03-01 [PMID: 16546102] (Bioassay, Human)
• Baginski TK, Dabbagh K, Satjawatcharaphong C, Swinney DC Cigarette smoke synergistically enhances respiratory mucin induction by proinflammatory stimuli. Am. J. Respir. Cell Mol. Biol., 2006-03-16;35(2):165-74. 2006-03-16 [PMID: 16543607] (Bioassay, Human)
• Kiryushko D, Pavon L, Novitskaya V, Sandoval-Lopez G, Soroka V, Eugenia Hernandez M, Klingelhofer J, Loria F, Lukanidin E, Estrada I, Berezin V, Perez M, Bock E, Moreno J, Avila U, Leff P, Anton B, Heinze G Th2 cytokine response in Major Depressive Disorder patients before treatment. J. Neuroimmunol., 2006-02-02;172(1):156-65. 2006-02-02 [PMID: 16457895] (ELISA (Standard))
• Fujitsu Y, Fukuda K, Kimura K, Seki K, Kumagai N, Nishida T Protection of human conjunctival fibroblasts from NO-induced apoptosis by interleukin-4 or interleukin-13. Invest. Ophthalmol. Vis. Sci., 2005-03-01;46(3):797-802. 2005-03-01 [PMID: 15728533] (Bioassay, Human)
• Kahlon KS, Brown C, Cooper LJ, Raubitschek A, Forman SJ, Jensen MC Specific recognition and killing of glioblastoma multiforme by interleukin 13-zetakine redirected cytolytic T cells. Cancer Res., 2004-12-15;64(24):9160-6. 2004-12-15 [PMID: 15604287] (Bioassay, Human)
• Kao CY, Chen Y, Thai P, Wachi S, Huang F, Kim C, Harper RW, Wu R IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways. J. Immunol., 2004-09-01;173(5):3482-91. 2004-09-01 [PMID: 15322213] (Bioassay, Human)
• Kajiwara K, Shinazawa M, Morishima H, Yanagihara Y Differential effect of IL-4 and IL-13 on the expression of recombination-activating genes in mature B cells from human peripheral blood. Cell. Immunol., 2004-02-01;227(2):121-8. 2004-02-01 [PMID: 15135294] (Bioassay, Human)
• Bellinghausen I, Brand P, Bottcher I, Klostermann B, Knop J, Saloga J Production of interleukin-13 by human dendritic cells after stimulation with protein allergens is a key factor for induction of T helper 2 cytokines and is associated with activation of signal transducer and activator of transcription-6. Immunology, 2003-02-01;108(2):167-76. 2003-02-01 [PMID: 12562325] (Bioassay, Human)
• Schmid-Grendelmeier P, Altznauer F, Fischer B, Bizer C, Straumann A, Menz G, Blaser K, Wuthrich B, Simon HU Eosinophils express functional IL-13 in eosinophilic inflammatory diseases. J. Immunol., 2002-07-15;169(2):1021-7. 2002-07-15 [PMID: 12097410] (Bioassay, Human)
• Liu X, Kohyama T, Wang H, Zhu YK, Wen FQ, Kim HJ, Romberger DJ, Rennard SI Th2 cytokine regulation of type I collagen gel contraction mediated by human lung mesenchymal cells. Am. J. Physiol. Lung Cell Mol. Physiol., 2002-05-01;282(5):L1049-56. 2002-05-01 [PMID: 11943670] (Bioassay, Human)

Bioinformatics

• Gene Symbol: IL13
• Uniprot:
  • AAK53823()