Recombinant Human CXCL11/I-TAC Protein

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Summary
Reactivity HuSpecies Glossary
Applications Bioactivity

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Recombinant Human CXCL11/I-TAC Protein Summary

Details of Functionality
Measured by its ability to chemoattract human peripheral blood lymphocytes (PBL) cultured in the presence of IL-2 for 21 days. The ED50 for this effect is 10‑20 ng/mL. Measured by its ability to chemoattract BaF3 mouse pro‑B cells transfected with human CXCR3. The ED50 for this effect is 1‑5 ng/mL.
Source
E. coli-derived human CXCL11/I-TAC protein
Phe22-Phe94
Accession #
N-terminal Sequence
Phe22
Protein/Peptide Type
Recombinant Proteins
Gene
CXCL11
Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Theoretical MW
8.3 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publications using
672-IT in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Reconstitution Instructions
Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human CXCL11/I-TAC Protein

  • beta-R1
  • b-R1
  • chemokine (C-X-C motif) ligand 11
  • CXCL11
  • H174
  • H174IP9
  • Interferon gamma-inducible protein 9
  • Interferon-inducible T-cell alpha chemoattractant
  • IP-9member 11
  • ITAC
  • I-TAC
  • I-TACMGC102770
  • SCYB9B
  • small inducible cytokine subfamily B (Cys-X-Cys), member 9B
  • Small-inducible cytokine B11

Background

CXCL11, also known as I-TAC, SCYB9B, H174 and beta -R1, is a non-ELR CXC chemokine. CXCL11 cDNA encodes a 94 amino acid (aa) residue precursor protein with a 21 aa residue putative signal sequence, which is cleaved to form the mature 73 aa residue protein. CXCL11 shares 36% and 37% amino acid sequence homology with IP-10 and MIG (two other known human non-ELR CXC chemokines), respectively. CXCL11 is expressed at low levels in normal tissues including thymus, spleen and pancreas. The expression of CXCL11 mRNA is radically up regulated in IFN-gamma and IL-1 stimulated astrocytes. Moderate increase in expression is also observed in stimulated monocytes. CXCL11 has potent chemoattractant activity for IL-2 activated T cells and transfected cell lines expressing CXCR3, but not freshly isolated T-cells, neutrophils or monocytes. The gene encoding CXCL11 has been mapped to chromosome 4.

  1. Cole, K. et al. (1998) J. Exp. Med. 187:2009.
  2. Sandhya Rani, M. et al. (1996) J. Biol. Chem. 271:22878.
  3. Lou, Y. et al. (1998) J. Neurovirol. 4:575.

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672-IT
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Applications: Bioactivity

Publications for CXCL11/I-TAC (672-IT)(13)

We have publications tested in 3 confirmed species: Human, Hamster, N/A.

We have publications tested in 3 applications: Bioassay, Competitive Binding Assay, ELISA Standard.


Filter By Application
Bioassay
(11)
Competitive Binding Assay
(1)
ELISA Standard
(1)
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Human
(11)
Hamster
(1)
N/A
(1)
All Species
Showing Publications 1 - 10 of 13. Show All 13 Publications.
Publications using 672-IT Applications Species
Hsiao J, Ng B, Smits M, Wang J, Jasavala R, Martinez H, Lee J, Alston J, Misonou H, Trimmer J, Wright M Androgen receptor and chemokine receptors 4 and 7 form a signaling axis to regulate CXCL12-dependent cellular motility. BMC Cancer, 2015;15(0):204. 2015 [PMID: 25884570] (Bioassay, Human) Bioassay Human
Liu, Che, Pham, Kien, Luo, Defang, Reynolds, Brent A, Hothi, Parvinde, Foltz, Gregory, Harrison, Jeffrey Expression and functional heterogeneity of chemokine receptors CXCR4 and CXCR7 in primary patient-derived glioblastoma cells. PLoS ONE, 2013;8(3):e59750. 2013 [PMID: 23555768] (Bioassay, Human) Bioassay Human
Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 2012;487(7408):505-9. 2012 [PMID: 22763448] (Bioassay, Human) Bioassay Human
Berahovich RD, Zabel BA, Penfold ME, Lewen S, Wang Y, Miao Z, Gan L, Pereda J, Dias J, Slukvin II, McGrath KE, Jaen JC, Schall TJ CXCR7 protein is not expressed on human or mouse leukocytes. J. Immunol., 2010;185(9):5130-9. 2010 [PMID: 20889540] (Competitive Binding Assay, Human) Competitive Binding Assay Human
Leick M, Catusse J, Follo M, Nibbs RJ, Hartmann TN, Veelken H, Burger M CCL19 is a specific ligand of the constitutively recycling atypical human chemokine receptor CRAM-B. Immunology, 2010;129(4):536-46. 2010 [PMID: 20002784] (Bioassay, Human) Bioassay Human
Hartl D, Krauss-Etschmann S, Koller B, Hordijk PL, Kuijpers TW, Hoffmann F, Hector A, Eber E, Marcos V, Bittmann I, Eickelberg O, Griese M, Roos D Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases. J. Immunol., 2008;181(11):8053-67. 2008 [PMID: 19017998] (Bioassay, Human) Bioassay Human
Loos T, Mortier A, Gouwy M, Ronsse I, Put W, Lenaerts JP, Van Damme J, Proost P Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation. Blood, 2008;112(7):2648-56. 2008 [PMID: 18645041] (Bioassay, Hamster) Bioassay Hamster
Winter D, Moser J, Kriehuber E, Wiesner C, Knobler R, Trautinger F, Bombosi P, Stingl G, Petzelbauer P, Rot A, Maurer D Down-modulation of CXCR3 surface expression and function in CD8+ T cells from cutaneous T cell lymphoma patients. J. Immunol., 2007;179(6):4272-82. 2007 [PMID: 17785868] (Bioassay, Human) Bioassay Human
Proost P, Mortier A, Loos T, Vandercappellen J, Gouwy M, Ronsse I, Schutyser E, Put W, Parmentier M, Struyf S, Van Damme J Proteolytic processing of CXCL11 by CD13/aminopeptidase N impairs CXCR3 and CXCR7 binding and signaling and reduces lymphocyte and endothelial cell migration. Blood, 2007;110(1):37-44. 2007 [PMID: 17363734] (Bioassay, Human) Bioassay Human
Nguyen AN, Stebbins EG, Henson M, O&amp;amp;apos;Young G, Choi SJ, Quon D, Damm D, Reddy M, Ma JY, Haghnazari E, Kapoun AM, Medicherla S, Protter A, Schreiner GF, Kurihara N, Anderson J, Roodman GD, Navas TA, Higgins LS Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and suppresses osteoclast formation. Exp. Cell Res., 2006;312(10):1909-23. 2006 [PMID: 16600214] (Bioassay, Human) Bioassay Human
Show All 13 Publications.

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Bioinformatics

Gene Symbol CXCL11
Entrez
Uniprot