Recombinant Human CXCL10/IP-10 Protein, CF

Recombinant Human CXCL10/IP-10/CRG-2 (Catalog # 266-IP/CF) chemoattracts the BaF3 mouse pro-B cell line transfected with human CXCR3. The ED50 for this effect is 0.03-0.18 μg/mL.

1 µg/lane of Recombinant Human CXCL10/IP-10/CRG-2 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 9 kDa.

• Reactivity: Hu
• Applications: Bioactivity
• Format: Carrier-Free

Recombinant Human CXCL10/IP-10 Protein, CF Summary

• Details of Functionality: Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CXCR3. The ED 50 for this effect is 0.03-0.18 µg/mL.
• Source: E. coli-derived human CXCL10/IP-10/CRG-2 protein Val22-Pro98, with an N-terminal Met
• Accession #: P02778.2
• N-terminal Sequence: Met
• Protein/Peptide Type: Recombinant Proteins
• Gene: CXCL10
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain
• Endotoxin Note: <0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 8.7 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 3 months, -20 to -70 degreesC under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS.
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain
• Reconstitution Instructions: Reconstitute at 100 μg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human CXCL10/IP-10 Protein, CF

• C7
• chemokine (C-X-C motif) ligand 10
• CRG2
• CRG-2
• CXCL10
• gIP-10
• IFI10
• INP10
• IP-10
• mob-1
• SCYB10

Background

CXCL10 was originally identified as an IFN-gamma -inducible gene in monocytes, fibroblasts and endothelial cells. It has since been shown that CXCL10 mRNA is also induced by LPS, IL-1 beta , TNF-alpha , IL-12 and viruses. Additional cell types that have been shown to express CXCL10 include activated T-lymphocytes, splenocytes, keratinocytes, osteoblasts, astrocytes, and smooth muscle cells. CXCL10 is also expressed in psoriatic and lepromatous lesions of skin. The mouse homologue of human CXCL10, Crg-2, has been cloned and shown to share approximately 67% amino acid sequence identity with human CXCL10. Human CXCL10 cDNA encodes a 98 amino acid (aa) residue precursor protein with a 21 aa residue signal peptide that is cleaved to form the 77 aa residue secreted protein. The amino acid sequence of CXCL10 identified the protein as a member of the chemokine alpha subfamily that lacks the ELR domain. CXCL10 has been shown to be a chemoattractant for activated T-lymphocytes. CXCL10 has been reported to be a potent inhibitor of angiogenesis and to display a potent thymus-dependent antitumor effect. A chemokine receptor specific for CXCL10 and Mig has been cloned and shown to be highly expressed in IL-2-activated T-lymphocytes.

1. Loetscher, M. et al. (1996) J. Exp. Med. 184:963.
2. Wang, X. et al .(1996) J. Biol. Chem. 271:24286.

Publications for CXCL10/IP-10/CRG-2 (266-IP/CF)(53)

Publications using 266-IP/CF

• LJ Pallett, L Swadling, M Diniz, AA Maini, M Schwabenla, AD Gasull, J Davies, S Kucykowicz, JK Skelton, N Thomas, NM Schmidt, OE Amin, US Gill, KA Stegmann, AR Burton, E Stephenson, G Reynolds, M Whelan, J Sanchez, R de Maeyer, C Thakker, K Suveizdyte, I Uddin, AM Ortega-Pri, C Grant, F Froghi, G Fusai, S Lens, S Pérez-Del-, W Al-Akkad, G Mazza, M Noursadegh, A Akbar, PTF Kennedy, BR Davidson, M Prinz, BM Chain, M Haniffa, DW Gilroy, M Dorner, B Bengsch, A Schurich, MK Maini Tissue CD14+CD8+ T cells reprogrammed by myeloid cells and modulated by LPS Nature, 2023-01-25;614(7947):334-342. 2023-01-25 [PMID: 36697826] (Bioassay, Human)
• R Lei, H Arain, M Obaid, N Sabhnani, C Mohan Ultra-Sensitive and Semi-Quantitative Vertical Flow Assay for the Rapid Detection of Interleukin-6 in Inflammatory Diseases Biosensors, 2022-09-14;12(9):. 2022-09-14 [PMID: 36140141] (Bioassay, Human)
• L Rijvers, J van Langel, L Bogers, MJ Melief, SC Koetzier, KM Blok, AF Wierenga-W, HE De Vries, J Rip, OB Corneth, RW Hendriks, R Grenninglo, U Boschert, J Smolders, MM van Luijn Human T-bet+ B cell development is associated with BTK activity and suppressed by evobrutinib JCI Insight, 2022-08-22;0(0):. 2022-08-22 [PMID: 35852869] (Bioassay, Human)
• ST Kim, Y Chu, M Misoi, ME Suarez-Alm, JH Tayar, H Lu, M Buni, J Kramer, E Rodriguez, Z Hussain, SS Neelapu, J Wang, AY Shah, NM Tannir, MT Campbell, DL Gibbons, T Cascone, C Lu, GR Blumensche, M Altan, B Lim, V Valero, ME Loghin, J Tu, SN Westin, A Naing, G Garcia-Man, N Abdel-Waha, HA Tawbi, P Hwu, ICG Oliva, MA Davies, SP Patel, J Zou, A Futreal, A Diab, L Wang, R Nurieva Distinct molecular and immune hallmarks of inflammatory arthritis induced by immune checkpoint inhibitors for cancer therapy Nature Communications, 2022-04-12;13(1):1970. 2022-04-12 [PMID: 35413951] (Bioassay, Human)
• L Déry, G Charest, B Guérin, M Akbari, D Fortin Chemoattraction of Neoplastic Glial Cells with CXCL10, CCL2 and CCL11 as a Paradigm for a Promising Therapeutic Approach for Primary Brain Tumors International Journal of Molecular Sciences, 2021-11-10;22(22):. 2021-11-10 [PMID: 34830041] (Bioassay, In Vivo, Human, Rat)
• M Kim, HY Choi, JW Woo, YR Chung, SY Park Role of CXCL10 in the progression of in situ to invasive carcinoma of the breast Scientific Reports, 2021-09-09;11(1):18007. 2021-09-09 [PMID: 34504204] (Bioassay, Human)
• R Ravindran, C McReynolds, J Yang, BD Hammock, A Ikram, A Ali, A Bashir, T Zohra, WLW Chang, DJ Hartigan-O, HH Rashidi, IH Khan Immune response dynamics in COVID-19 patients to SARS-CoV-2 and other human coronaviruses PLoS ONE, 2021-07-09;16(7):e0254367. 2021-07-09 [PMID: 34242356] (ELISA Standard, Human)
• C Kötting, L Hofmann, R Lotfi, D Engelhardt, S Laban, PJ Schuler, TK Hoffmann, C Brunner, MN Theodoraki Immune-Stimulatory Effects of Curcumin on the Tumor Microenvironment in Head and Neck Squamous Cell Carcinoma Cancers, 2021-03-16;13(6):. 2021-03-16 [PMID: 33809574] (Human)
• D Biasci, M Smoragiewi, CM Connell, Z Wang, Y Gao, JED Thaventhir, B Basu, L Magiera, TI Johnson, L Bax, A Gopinathan, C Isherwood, FA Gallagher, M Pawula, I Hudecova, D Gale, N Rosenfeld, P Barmpounak, EC Popa, R Brais, E Godfrey, F Mir, FM Richards, DT Fearon, T Janowitz, DI Jodrell CXCR4 inhibition in human pancreatic and colorectal cancers induces an integrated immune response Proc Natl Acad Sci U S A, 2020-10-30;0(0):. 2020-10-30 [PMID: 33127761] (Bioassay, Human)
• LA Callender, EC Carroll, EA Bober, AN Akbar, E Solito, SM Henson Mitochondrial mass governs the extent of human T cell senescence Aging Cell, 2019-12-02;0(0):e13067. 2019-12-02 [PMID: 31788930] (Bioassay, Human)
• M Goedhart, S Gessel, R van der Vo, E Slot, B Lucas, E Gielen, M Hoogenboez, T Rademakers, S Geerman, JD van Buul, S Huveneers, H Dolstra, G Anderson, C Voermans, MA Nolte CXCR4, but not CXCR3, drives CD8 T-cell entry into and migration through the murine bone marrow Eur. J. Immunol., 2019-02-15;0(0):. 2019-02-15 [PMID: 30707456] (Bioassay, Human)
• HK Lee, KH Kim, HS Kim, JS Kim, JH Lee, A Ji, KS Kim, TY Lee, IY Chang, SC Bae, JT Hong, Y Kim, SB Han Effect of a Combination of Prednisone or Mycophenolate Mofetil and Mesenchymal Stem Cells on Lupus Symptoms in MRL.Faslpr Mice Stem Cells Int, 2018-07-03;2018(0):4273107. 2018-07-03 [PMID: 30057623] (Bioassay, Human)
• B Gao, J Lin, Z Jiang, Z Yang, H Yu, L Ding, M Yu, Q Cui, N Dunavin, M Zhang, M Li Upregulation of chemokine CXCL10 enhances chronic pulmonary inflammation in tree shrew collagen-induced arthritis Sci Rep, 2018-07-03;8(1):9993. 2018-07-03 [PMID: 29968810] (Bioassay, Tree Shrew)
• M Liu, W Solomon, JC Cespedes, NO Wilson, B Ford, JK Stiles Neuregulin-1 attenuates experimental cerebral malaria (ECM) pathogenesis by regulating ErbB4/AKT/STAT3 signaling J Neuroinflammation, 2018-04-10;15(1):104. 2018-04-10 [PMID: 29636063] (Bioassay, Human)
• Z Jiang, Y Li, X Ji, Y Tang, H Yu, L Ding, M Yu, Q Cui, M Zhang, Y Ma, M Li Protein profiling identified key chemokines that regulate the maintenance of human pluripotent stem cells Sci Rep, 2017-11-06;7(1):14510. 2017-11-06 [PMID: 29109449] (Bioassay, Human)
• B Schludi, ASM Moin, C Montemurro, T Gurlo, AV Matveyenko, D Kirakossia, DW Dawson, SM Dry, PC Butler, AE Butler Islet inflammation and ductal proliferation may be linked to increased pancreatitis risk in type 2 diabetes JCI Insight, 2017-07-06;2(13):. 2017-07-06 [PMID: 28679961] (Bioassay, Human)
• H Bronger, A Karge, T Dreyer, D Zech, S Kraeft, S Avril, M Kiechle, M Schmitt Induction of cathepsin B by the CXCR3 chemokines CXCL9 and CXCL10 in human breast cancer cells Oncol Lett, 2017-04-05;13(6):4224-4230. 2017-04-05 [PMID: 28599423] (Bioassay, Human)
• N Rahman, PM Brauer, L Ho, T Usenko, M Tewary, JC Zúñiga-Pfl, PW Zandstra Engineering the haemogenic niche mitigates endogenous inhibitory signals and controls pluripotent stem cell-derived blood emergence Nat Commun, 2017-05-25;8(0):15380. 2017-05-25 [PMID: 28541275] (Bioassay, Human)
• Jung Yong Hong Serum level of CXCL10 is associated with inflammatory prognostic biomarkers in patients with diffuse large B-cell lymphoma Hematol Oncol, 2016-12-12;0(0):. 2016-12-12 [PMID: 27943355] (Bioassay, Human)
• Valentina Cecchinato Impairment of CCR6+ and CXCR3+ Th Cell Migration in HIV-1 Infection Is Rescued by Modulating Actin Polymerization J. Immunol, 2016-11-28;0(0):. 2016-11-28 [PMID: 27895171] (Bioassay, Human, Primate - Macaca mulatta (Rhesus Macaque))
• Fc receptor-mediated phagocytosis in tissues as a potent mechanism for preventive and therapeutic HIV vaccine strategies Mucosal Immunol, 2016-02-17;9(6):1584-1595. 2016-02-17 [PMID: 26883728] (Bioassay, Human)
• Altara , Raffaele, Manca , Marco, Hessel , Marleen, Janssen , Ben J, Struijker-Boudier , Harry H, Hermans , Rob J J, Blankesteijn , W Matthi Improving membrane based multiplex immunoassays for semi-quantitative detection of multiple cytokines in a single sample. BMC Biotechnol, 2014-07-15;14(0):63. 2014-07-15 [PMID: 25022797] (ELISA (Standard))
• Karta , Maya R, Wickert , Lisa E, Curran , Colleen, Gavala , Monica L, Denlinger , Loren C, Gern , James E, Bertics , Paul J Allergen challenge in vivo alters rhinovirus-induced chemokine secretion from human airway macrophages. J Allergy Clin Immunol, 2014-02-14;133(4):1227-30. 2014-02-14 [PMID: 24529411] (Human)
• Lo H, Lai T, Li C, Wu W TNF-alpha induces CXCL1 chemokine expression and release in human vascular endothelial cells in vitro via two distinct signaling pathways. Acta Pharmacol Sin, 2014-02-03;35(3):339-50. 2014-02-03 [PMID: 24487964] (Bioassay, Human)
• Craig V, Quintero P, Fyfe S, Patel A, Knolle M, Kobzik L, Owen C Profibrotic activities for matrix metalloproteinase-8 during bleomycin-mediated lung injury. J Immunol, 2013-03-13;190(8):4283-96. 2013-03-13 [PMID: 23487425] (Enzyme Assay, Mouse)
• Sela H, Goldman-Wohl D, Haimov-Kochman R, Greenfield C, Natanson-Yaron S, Hamani Y, Revel A, Lavy Y, Singer O, Yachimovich-Cohen N, Turetsky T, Mandelboim O, Reubinoff B, Yagel S Human trophectoderm apposition is regulated by interferon gamma-induced protein 10 (IP-10) during early implantation. Placenta, 2013-01-08;34(3):222-30. 2013-01-08 [PMID: 23306067] (Bioassay, Human)
• Macrophages induce differentiation of plasma cells through CXCL10/IP-10. J. Exp. Med., 2012-09-17;209(10):1813-23. 2012-09-17 [PMID: 22987802] (Bioassay, Human)
• Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 2012-07-26;487(7408):505-9. 2012-07-26 [PMID: 22763448] (Bioassay, Human)
• Vujanovic , Lazar, Ballard , Wenners, Thorne , Stephen, Vujanovic , Nikola L, Butterfield , Lisa H Adenovirus-engineered human dendritic cells induce natural killer cell chemotaxis via CXCL8/IL-8 and CXCL10/IP-10. Oncoimmunology, 2012-07-01;1(4):448-457. 2012-07-01 [PMID: 22754763] (Bioassay, Human)
• Badr G, Lefevre EA, Mohany M Thymoquinone inhibits the CXCL12-induced chemotaxis of multiple myeloma cells and increases their susceptibility to Fas-mediated apoptosis. PLoS ONE, 2011-09-01;6(9):e23741. 2011-09-01 [PMID: 21912642] (Bioassay, Human)
• Liu C, Luo D, Reynolds BA Chemokine receptor CXCR3 promotes growth of glioma. Carcinogenesis, 2010-11-03;32(2):129-37. 2010-11-03 [PMID: 21051441] (Bioassay, Human)
• Shan M, Cheng HF, Song LZ Lung myeloid dendritic cells coordinately induce TH1 and TH17 responses in human emphysema. Sci Transl Med, 2009-10-28;1(4):4ra10. 2009-10-28 [PMID: 20368170] (Bioassay, Human)
• Kelly-Scumpia KM, Scumpia PO, Delano MJ, Weinstein JS, Cuenca AG, Wynn JL, Moldawer LL Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10. J. Exp. Med., 2010-01-13;207(2):319-26. 2010-01-13 [PMID: 20071504] (Bioassay, In Vivo, Human, Mouse)
• Zhu Y, Vergote D, Pardo C, Noorbakhsh F, McArthur JC, Hollenberg MD, Overall CM, Power C CXCR3 activation by lentivirus infection suppresses neuronal autophagy: neuroprotective effects of antiretroviral therapy. FASEB J., 2009-04-20;23(9):2928-41. 2009-04-20 [PMID: 19380511] (Bioassay, Human)
• Skrzeczynska-Moncznik J, Wawro K, Stefanska A, Oleszycka E, Kulig P, Zabel BA, Sulkowski M, Kapinska-Mrowiecka M, Czubak-Macugowska M, Butcher EC, Cichy J Potential role of chemerin in recruitment of plasmacytoid dendritic cells to diseased skin. Biochem. Biophys. Res. Commun., 2009-01-23;380(2):323-7. 2009-01-23 [PMID: 19168032] (Bioassay, Human)
• Biancotto A, Iglehart SJ, Lisco A, Vanpouille C, Grivel JC, Lurain NS, Reichelderfer PS, Margolis LB Upregulation of human cytomegalovirus by HIV type 1 in human lymphoid tissue ex vivo. AIDS Res. Hum. Retroviruses, 2008-03-01;24(3):453-62. 2008-03-01 [PMID: 18327985] (ELISA (Standard))
• Qui H, Ferrell EP, Nolan N, Phelps BH, Tabibiazar R, Whitney DH, Naelfski EA Fluorescence single-molecule counting assays for high-sensitivity detection of cytokines and chemokines. Clin. Chem., 2007-11-01;53(11):2010-2. 2007-11-01 [PMID: 18030696] (ELISA (Standard))
• Pfleger C, Schloot N, ter Veld F Effect of serum content and diluent selection on assay sensitivity and signal intensity in multiplex bead-based immunoassays. J. Immunol. Methods, 2007-10-22;329(1):214-8. 2007-10-22 [PMID: 17964594] (ELISA (Standard))
• Liu LY, Bates ME, Jarjour NN, Busse WW, Bertics PJ, Kelly EA Generation of Th1 and Th2 chemokines by human eosinophils: evidence for a critical role of TNF-alpha. J. Immunol., 2007-10-01;179(7):4840-8. 2007-10-01 [PMID: 17878383] (ELISA (Standard))
• Facco M, Baesso I, Miorin M, Bortoli M, Cabrelle A, Boscaro E, Gurrieri C, Trentin L, Zambello R, Calabrese F, Cassatella MA, Semenzato G, Agostini C Expression and role of CCR6/CCL20 chemokine axis in pulmonary sarcoidosis. J. Leukoc. Biol., 2007-07-05;82(4):946-55. 2007-07-05 [PMID: 17615381] (Bioassay, Human)
• Grivel JC, Elliott J, Lisco A, Biancotto A, Condack C, Shattock RJ, McGowan I, Margolis L, Anton P HIV-1 pathogenesis differs in rectosigmoid and tonsillar tissues infected ex vivo with CCR5- and CXCR4-tropic HIV-1. AIDS, 2007;21(10):1263-72. 2007 [PMID: 17545702] (ELISA (Standard), N/A)
• Biancotto A, Grivel JC, Iglehart SJ, Vanpouille C, Lisco A, Sieg SF, Debernardo R, Garate K, Rodriguez B, Margolis LB, Lederman MM Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1. Blood, 2007-02-08;109(10):4272-9. 2007-02-08 [PMID: 17289812] (ELISA (Standard))
• Datta D, Flaxenburg JA, Laxmanan S, Geehan C, Grimm M, Waaga-Gasser AM, Briscoe DM, Pal S Ras-induced modulation of CXCL10 and its receptor splice variant CXCR3-B in MDA-MB-435 and MCF-7 cells: relevance for the development of human breast cancer. Cancer Res., 2006-10-01;66(19):9509-18. 2006-10-01 [PMID: 17018607] (Bioassay, Human)
• Gounni Abdelilah S, Wellemans V, Agouli M, Guenounou M, Hamid Q, Beck LA, Lamkhioued B Increased expression of Th2-associated chemokines in bullous pemphigoid disease. Role of eosinophils in the production and release of these chemokines. Clin. Immunol., 2006-06-16;120(2):220-31. 2006-06-16 [PMID: 16782408] (ELISA (Standard))
• Nakayama T, Shirane J, Hieshima K, Shibano M, Watanabe M, Jin Z, Nagakubo D, Saito T, Shimomura Y, Yoshie O Novel antiviral activity of chemokines. Virology, 2006-04-17;350(2):484-92. 2006-04-17 [PMID: 16603217] (Binding Assay, Bioassay, Virus)
• Nguyen AN, Stebbins EG, Henson M, O&amp;apos;Young G, Choi SJ, Quon D, Damm D, Reddy M, Ma JY, Haghnazari E, Kapoun AM, Medicherla S, Protter A, Schreiner GF, Kurihara N, Anderson J, Roodman GD, Navas TA, Higgins LS Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and suppresses osteoclast formation. Exp. Cell Res., 2006-04-04;312(10):1909-23. 2006-04-04 [PMID: 16600214] (Bioassay, Human)
• Edwards MR, Johnson MW, Johnston SL Combination therapy: Synergistic suppression of virus-induced chemokines in airway epithelial cells. Am. J. Respir. Cell Mol. Biol., 2006-01-19;34(5):616-24. 2006-01-19 [PMID: 16424382] (ELISA (Standard))
• Meller S, Winterberg F, Gilliet M, Muller A, Lauceviciute I, Rieker J, Neumann NJ, Kubitza R, Gombert M, Bunemann E, Wiesner U, Franken-Kunkel P, Kanzler H, Dieu-Nosjean MC, Amara A, Ruzicka T, Lehmann P, Zlotnik A, Homey B Ultraviolet radiation-induced injury, chemokines, and leukocyte recruitment: An amplification cycle triggering cutaneous lupus erythematosus. Arthritis Rheum., 2005-05-01;52(5):1504-16. 2005-05-01 [PMID: 15880822] (Bioassay, Human)
• Wald O, Pappo O, Safadi R, Dagan-Berger M, Beider K, Wald H, Franitza S, Weiss I, Avniel S, Boaz P, Hanna J, Zamir G, Eid A, Mandelboim O, Spengler U, Galun E, Peled A Involvement of the CXCL12/CXCR4 pathway in the advanced liver disease that is associated with hepatitis C virus or hepatitis B virus. Eur. J. Immunol., 2004-04-01;34(4):1164-74. 2004-04-01 [PMID: 15048728] (Bioassay, Human)
• Oynebraten I, Bakke O, Brandtzaeg P, Johansen FE, Haraldsen G Rapid chemokine secretion from endothelial cells originates from 2 distinct compartments. Blood, 2004-03-25;104(2):314-20. 2004-03-25 [PMID: 15044249] (ELISA (Standard))
• Keane MP, Donnelly SC, Belperio JA, Goodman RB, Dy M, Burdick MD, Fishbein MC, Strieter RM Imbalance in the expression of CXC chemokines correlates with bronchoalveolar lavage fluid angiogenic activity and procollagen levels in acute respiratory distress syndrome. J. Immunol., 2002-12-01;169(11):6515-21. 2002-12-01 [PMID: 12444162] (ELISA (Standard))
• Hurst SM, McLoughlin RM, Monslow J, Owens S, Morgan L, Fuller GM, Topley N, Jones SA Secretion of oncostatin M by infiltrating neutrophils: regulation of IL-6 and chemokine expression in human mesothelial cells. J. Immunol., 2002-11-01;169(9):5244-51. 2002-11-01 [PMID: 12391243] (ELISA (Standard))
• de Lavareille A, Roufosse F, Schandene L, Stordeur P, Cogan E, Goldman M Clonal Th2 cells associated with chronic hypereosinophilia: TARC-induced CCR4 down-regulation in vivo. Eur. J. Immunol., 2001-04-01;31(4):1037-46. 2001-04-01 [PMID: 11298328] (Bioassay, Human)

Bioinformatics

• Gene Symbol: CXCL10
• Uniprot:
  • P02778.2()