Recombinant Human BOC Protein, CF


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Product Details

Reactivity HuSpecies Glossary
Applications Binding Activity

Order Details

Recombinant Human BOC Protein, CF Summary

Details of Functionality
Measured by its binding ability in a functional ELISA. Immobilized rhSHH at 4 µg/mL can bind rhBOC with an apparent KD <5 nM.
Mouse myeloma cell line, NS0-derived human BOC protein
Asp31-Asp852 & Leu417-Asp852, both with a C-terminal 6-His tag
Accession #
N-terminal Sequence
Asp31 & Leu417
Protein/Peptide Type
Recombinant Proteins
>85%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.


Theoretical MW
91.1 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
135 kDa, reducing conditions
Read Publication using
2036-BC in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS.
>85%, by SDS-PAGE under reducing conditions and visualized by silver stain
Reconstitution Instructions
Reconstitute at 100 μg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human BOC Protein, CF

  • Boc homolog (mouse)
  • BOC
  • brother of CDO
  • Protein BOC


BOC (Brother of CDO [CAM-related/down-regulated by oncogenes]) is a member of the Immunoglobulin (Ig) superfamily, Ig/Fibronectin (FN) type III repeat family of cell surface proteins (1). Human BOC is a type I transmembrane (TM) protein. It is synthesized as a 1114 amino acid (aa) precursor that contains a 30 aa signal sequence, an 825 aa extracellular domain (ECD), a 21 aa TM segment and a 238 aa cytoplasmic region (1, 2). The ECD contains four Ig-like domains, followed by three FN type III repeats. The third (or juxtramembrane) FN type III repeat (aa 712 - 809) binds SHH (3). The intracellular region is not essential for BOC-containing receptor complex signaling (1). However, it appears both the ECD and intracellular regions of BOC are used to form functional subunit interactions in cis-oriented receptor complexes (1, 4). One 157 aa BOC alternate splice form is reported that shows a 32 aa substitution for aa 126 - 1114. The ECD of human BOC is 92% aa identical to mouse BOC ECD. BOC is found in the embryo associated with muscle precursors, limb mesenchyme, early chondrocytes and neurons (2, 5, 6). It appears to promote muscle differentiation and axon guidance (2, 6). BOC contributes to two multi-subunit receptor complexes. On myocytes, a BOC-associated complex includes CDO, neogenin, netrin, and at least two cadherin homodimers formed by either M- or N-cadherin (2). A second complex on neurons, somewhat ill-defined, potentially includes BOC, CDO and Gas1. Here, BOC and/or CDO interact with SHH, with subsequent “transfer” or presentation of SHH to PTCH1 (6, 7).

  1. Kang, J.-S. et al. (2002) EMBO J. 21:114.
  2. Krauss, R.S. et al. (2005) J. Cell Sci. 118:2355.
  3. Yao, S. et al. (2006) Cell 125:343.
  4. Kang, J.-S. et al. (2003) Proc. Natl. Acad. Sci. USA 100:3989.
  5. Mulieri, P.J. et al. (2002) Dev. Dyn. 223:379.
  6. Okada, A. et al. (2006) Nature 444:369.
  7. Allen, B.L. et al. (2007) Genes Dev. 21:1244.

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Publications for BOC (2036-BC)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Bioassay.

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Gene Symbol BOC