RCOR1/CoREST Antibody [Alexa Fluor™ Plus 405]

• Reactivity: Hu, Mu
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Alexa Fluor Plus 405

RCOR1/CoREST Antibody [Alexa Fluor™ Plus 405] Summary

• Specificity: Detects human and mouse RCOR1/CoREST in direct ELISAs and Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for RCOR1/CoREST Antibody [Alexa Fluor™ Plus 405]

• CoREST
• KIAA0071CORESTRCORREST corepressor
• Protein CoREST
• RCOR1
• RCOR1/CoREST
• REST corepressor 1

Background

RCOR1 (REST [RE-1 silencing transcription factor] CORepressor 1; also CoREST) is a 64‑66 kDa member of the CoREST family of proteins. It is a nuclear protein that is ubiquitously expressed. RCOR1 serves as a molecular bridge, linking REST with Sin3, HDAC, LSD1, histone H3 K9 methyltransferases, and MeCP2. This creates a complex that represses the expression of neuron‑specific genes in nonneuronal cells, principally by coordinating the demethylation of Lys4 in histone H3. Human RCOR1 is 482 amino acids (aa) in length. It contains one ELM2 domain (aa 102‑157) that interacts with HDAC, and two SANT sequences (aa 187‑238 and 378‑429) that bind DNA tandem repeats. There are three potential RCOR1 splice variants. One contains a four aa substitution for aa 296‑482, a second shows an alternative start site 3 aa upstream of the standard site, while a third shares the same upstream start site accompanied by a 15 aa substitution for aa 471‑482. Over aa 394‑482, human RCOR1 shares 93% aa identity with mouse RCOR1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.