RCAN2 Antibody - BSA Free

Western Blot: RCAN2 Antibody [NBP1-76995] - 3T3 cell lysate with RCAN2 antibody at (A) 1 and (B) 2 ug/mL.

Immunohistochemistry: RCAN2 Antibody - BSA Free [NBP1-76995] - Immunohistochemistry of RCAN2 in mouse brain tissue with RCAN2 antibody at 2.5 ug/mL.

Immunocytochemistry/ Immunofluorescence: RCAN2 Antibody - BSA Free [NBP1-76995] - Immunofluorescence of RCAN2 in mouse brain tissue with RCAN2 antibody at 20 ug/mL.

• Reactivity: Hu, Mu, Rt, Bv
• Applications: WB, ELISA, ICC/IF, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

RCAN2 Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit RCAN2 Antibody - BSA Free (NBP1-76995) is a polyclonal antibody validated for use in IHC, WB, ELISA and ICC/IF. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Antibody was raised against a 14 amino acid synthetic peptide near the center of human RCAN2. The immunogen is located within amino acids 70 - 120 of RCAN2. Amino Acid Squence: AQVQTPETDGDKLH
• Predicted Species: Bovine (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: RCAN2
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence 20 ug/ml
  • Immunohistochemistry 2.5 ug/ml
  • Immunohistochemistry-Paraffin 2.5 ug/ml
  • Western Blot 1-2 ug/ml
• Control Peptide:

  RCAN2 Peptide (NBP1-76995PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for RCAN2 Antibody - BSA Free

• Calcipressin 2 (Thyroid hormone-responsive protein ZAKI-4) (Down syndromecandidate region 1-like 1) (Myocyte-enriched calcineurin interacting protein2) (MCIP2)
• calcipressin-2
• Down syndrome candidate region 1-like 1
• Down syndrome critical region gene 1-like 1
• DSCR1L1MCIP2ZAKI4RCN2
• hRCN2
• Myocyte-enriched calcineurin-interacting protein 2
• regulator of calcineurin 2CSP2
• thyroid hormone-responsive (skin fibroblasts)
• Thyroid hormone-responsive protein ZAKI-4
• ZAKI-4

Background

Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle. Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin's activity. Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3. RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome. Multiple isoforms of RCAN2 are known to exist.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: RCAN2
• Uniprot:
  • AAH62141(Mouse)