RCAN1 Antibody [DyLight 405]


There are currently no images for RCAN1 Antibody (NBP1-46852V).

Every product we sell is backed by Novus' 100% Guarantee. If you have used this product, please submit your images and reviews to earn reward points.

Product Details

Reactivity Hu, MuSpecies Glossary
Applications WB, IHC, IHC-P
Please see the vial label for concentration. If unlisted please contact technical services.

RCAN1 Antibody [DyLight 405] Summary

Synthetic peptide made to an internal portion of human RCAN1 (within residues 40-90). [Swiss-Prot# P53805]
Cytoplasm, nucleus
This antibody is specific for isoform 1-1L.
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Store at 4C in the dark.
DyLight 405
DyLight 405 (A=400, E=420)
50mM Sodium Borate
0.05% Sodium Azide
Please see the vial label for concentration. If unlisted please contact technical services.
Immunogen affinity purified


Application Notes
This RCAN1 antibody is useful for Western blot and Immunohistochemistry on paraffin-embedded sections. In WB a band is seen at ~38 kDa representing isoform RCAN1-1L.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
38 kDa

Reactivity Notes

Human and mouse.

Alternate Names for RCAN1 Antibody [DyLight 405]

  • ADAPT78
  • calcipressin-1
  • calcium and oxidant-inducible mRNA
  • Down syndrome candidate region 1
  • Down syndrome critical region gene 1
  • Down syndrome critical region protein 1
  • DSC1
  • modulatory calcineurin-interacting protein 1
  • Myocyte-enriched calcineurin-interacting protein 1
  • near DSCR proline-rich protein
  • regulator of calcineurin 1CSP1DSCR1MCIP1RCN1


RCAN1 (regulator of calcineurin 1) inhibits the calcineurin-dependent transcriptional responses by binding to catalytic domain of calcineurin 1, a protein phosphatase involved in muscle cell differentiation/growth, T cell activation and new memory generation. Unphosphorylated RCAN1 binds/inhibits calcineurin, while RCAN1 phosphorylation at conserved serine residues interefere with this binding, resulting in increased calcineurin activity. RCAN1 over-expression mediated reduction in calcineurin activity alters the phosphorylation/activity of several calcineurin targets such as Munc18, dynamin 1, amphiphysin 1/2 and synaptojanin which are involved in exocytosis and vesicle recycling. Chronic alterations in calcineurin lead to transcriptional effects via calcineurin/NFAT signalling that regulates pre-synaptic neurotransmitter release. RCAN1 also affect exocytosis and quantal release kinetics via direct calcineurin independent mechanisms. RCAN1 is widely expressed in normal tissues/cell types with highest expression in neurons, and RCAN1 levels elevates in Down syndrome fetuses as well as Alzheimer patients, whereas, in Huntington disease RCAN1 - expression is found reduced. RCAN1 has been implicated in a variety of cellular processes, including oxidative stress, angiogenesis, mitochondrial function, immune responses and inflammation.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
Species: Mu
Applications: WB, IHC
Species: Hu
Applications: WB, IHC
Species: Mu
Applications: IHC
Species: Hu
Applications: ICC/IF, IHC, IHC-P
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Species: Hu, Mu
Applications: WB, Simple Western, ICC/IF
Species: Hu, Mu, Rt
Applications: WB, Simple Western, IHC, IHC-P
Species: Hu, Mu, Rt
Applications: WB, ELISA, IHC, IP, S-ELISA
Species: Hu
Applications: WB, Flow, ICC/IF, IHC, IHC-P, IP
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Species: Hu
Applications: WB, IHC, IHC-P
Species: Hu, Mu
Applications: WB, Simple Western
Species: Hu, Rt, Ca, Mk
Applications: WB, IHC, IHC-P, IP

Publications for RCAN1 Antibody (NBP1-46852V) (0)

There are no publications for RCAN1 Antibody (NBP1-46852V).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for RCAN1 Antibody (NBP1-46852V) (0)

There are no reviews for RCAN1 Antibody (NBP1-46852V). By submitting a review earn points towards our Rewards Program.
  • 250 points for product review
  • 500 additional points for an image with your product review
  • Double points (500) if you are the first to review this product
  • Double points (1000) if you are the first to review this product with an image

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for RCAN1 Antibody (NBP1-46852V) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies


Isotype Controls

Additional RCAN1 Antibody [DyLight 405] Products

Related Products by Gene

Bioinformatics Tool for RCAN1 Antibody (NBP1-46852V)

Discover related pathways, diseases and genes to RCAN1 Antibody (NBP1-46852V). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for RCAN1 Antibody (NBP1-46852V)

Discover more about diseases related to RCAN1 Antibody (NBP1-46852V).

Pathways for RCAN1 Antibody (NBP1-46852V)

View related products by pathway.

PTMs for RCAN1 Antibody (NBP1-46852V)

Learn more about PTMs related to RCAN1 Antibody (NBP1-46852V).

Research Areas for RCAN1 Antibody (NBP1-46852V)

Find related products by research area.

Blogs on RCAN1

There are no specific blogs for RCAN1, but you can read our latest blog posts.

Contact Information

Product PDFs


Gene Symbol RCAN1

Customer Resources

Novus Review - Submit your review and earn rewards points which can be used for merchandise & discounts.
Risk Free Testing - Test on a species/application not listed above to receive a full credit towards a future purchase.

Novus' Quality Guarantee - Novus guarantees that every product we sell will work in the application and species listed on our website and datasheets.

Submit your question on NBP1-46852V below.
During business hours, we will respond to your email within 24 hours. For any questions submitted on the weekend, a response will be received on Monday.
For immediate assistance during business hours M- F (excluding major holidays), please contact us.
Ask a Scientist - We have a lab full of white coats just waiting for your scientific questions and concerns.

Customers Who Bought This Also Bought

RCAN1 Peptide
RCAN1 Peptide