RCAN1 Antibody [DyLight 405]

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
DyLight 405

RCAN1 Antibody [DyLight 405] Summary

Immunogen
Synthetic peptide made to an internal portion of human RCAN1 (within residues 40-90). [Swiss-Prot# P53805]
Localization
Cytoplasm, nucleus
Specificity
This antibody is specific for isoform 1-1L.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
RCAN1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
This RCAN1 antibody is useful for Western blot and Immunohistochemistry on paraffin-embedded sections. In WB a band is seen at ~38 kDa representing isoform RCAN1-1L.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
38 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human and mouse.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for RCAN1 Antibody [DyLight 405]

  • ADAPT78
  • calcipressin-1
  • calcium and oxidant-inducible mRNA
  • Down syndrome candidate region 1
  • Down syndrome critical region gene 1
  • Down syndrome critical region protein 1
  • DSC1
  • modulatory calcineurin-interacting protein 1
  • Myocyte-enriched calcineurin-interacting protein 1
  • near DSCR proline-rich protein
  • regulator of calcineurin 1CSP1DSCR1MCIP1RCN1

Background

RCAN1 (regulator of calcineurin 1) inhibits the calcineurin-dependent transcriptional responses by binding to catalytic domain of calcineurin 1, a protein phosphatase involved in muscle cell differentiation/growth, T cell activation and new memory generation. Unphosphorylated RCAN1 binds/inhibits calcineurin, while RCAN1 phosphorylation at conserved serine residues interefere with this binding, resulting in increased calcineurin activity. RCAN1 over-expression mediated reduction in calcineurin activity alters the phosphorylation/activity of several calcineurin targets such as Munc18, dynamin 1, amphiphysin 1/2 and synaptojanin which are involved in exocytosis and vesicle recycling. Chronic alterations in calcineurin lead to transcriptional effects via calcineurin/NFAT signalling that regulates pre-synaptic neurotransmitter release. RCAN1 also affect exocytosis and quantal release kinetics via direct calcineurin independent mechanisms. RCAN1 is widely expressed in normal tissues/cell types with highest expression in neurons, and RCAN1 levels elevates in Down syndrome fetuses as well as Alzheimer patients, whereas, in Huntington disease RCAN1 - expression is found reduced. RCAN1 has been implicated in a variety of cellular processes, including oxidative stress, angiogenesis, mitochondrial function, immune responses and inflammation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol RCAN1