RCAN1 Antibody [DyLight 550]

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
DyLight 550

RCAN1 Antibody [DyLight 550] Summary

Immunogen
Synthetic peptide made to an internal portion of human RCAN1 (within residues 40-90). [Swiss-Prot# P53805]
Localization
Cytoplasm, nucleus
Specificity
This antibody is specific for isoform 1-1L.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
RCAN1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
This RCAN1 antibody is useful for Western blot and Immunohistochemistry on paraffin-embedded sections. In WB a band is seen at ~38 kDa representing isoform RCAN1-1L.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
38 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human and mouse.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for RCAN1 Antibody [DyLight 550]

  • ADAPT78
  • calcipressin-1
  • calcium and oxidant-inducible mRNA
  • Down syndrome candidate region 1
  • Down syndrome critical region gene 1
  • Down syndrome critical region protein 1
  • DSC1
  • modulatory calcineurin-interacting protein 1
  • Myocyte-enriched calcineurin-interacting protein 1
  • near DSCR proline-rich protein
  • regulator of calcineurin 1CSP1DSCR1MCIP1RCN1

Background

The RCAN1 protein interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. This antibody is specific for Isoform RCAN1-1L, which is overexpressed in Alzheimer's Disease (Harris, C.D. et al) and is downregulated in Huntington's Disease (Ermak, G. et al).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol RCAN1