RBPMS Antibody (1090828) [Alexa Fluor™ Plus 647]

• Reactivity: Hu
• Clone: 1090828
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 647

RBPMS Antibody (1090828) [Alexa Fluor™ Plus 647] Summary

• Specificity: Detects a peptide specific for human RBPMS around amino acid 150 in Direct ELISA.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for RBPMS Antibody (1090828) [Alexa Fluor™ Plus 647]

• FLJ32971
• Heart and RRM expressed sequence
• HERMES
• HERMESRNA-binding protein with multiple splicing
• RBPMS
• RBP-MS
• RNA binding protein with multiple splicing

Background

RBPMS is a 22kDa protein that is a member of the RRM family of RNA-binding proteins.  RBPMS has been identified as a critical splicing regulator in differentiated vascular smooth muscle cells.  RBPMS is expressed at high levels in the heart, breasts, lungs, kidneys, stomach, muscles, liver, eyes, adipose tissue, and ovaries.  Studies in breast cancer and ovarian cancer show that RBPMS has a potential role as a tumor suppressor.

1. Nakagaki-Silva EE, Gooding C, Llorian M, Jacob AG, Richards F, Buckroyd A, Sinha S, Smith CWJ. Identification of RBPMS as a mammalian smooth muscle master splicing regulator via proximity of its gene with super-enhancers. Elife. 2019 Jul 8;8:e46327. doi: 10.7554/eLife.46327. PMID: 31283468; PMCID: PMC6613909. 
2. Rabelo-Fernández RJ, Santiago-Sánchez GS, Sharma RK, Roche-Lima A, Carrion KC, Rivera RAN, Quiñones-Díaz BI, Rajasekaran S, Siddiqui J, Miles W, Rivera YS, Valiyeva F, Vivas-Mejia PE. Reduced RBPMS Levels Promote Cell Proliferation and Decrease Cisplatin Sensitivity in Ovarian Cancer Cells. Int J Mol Sci. 2022 Jan 4;23(1):535. doi: 10.3390/ijms23010535. PMID: 35008958; PMCID: PMC8745614.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.