Rat IL-6 DuoSet ELISA, 15 Plate

• Reactivity: Rt
• Applications: ELISA
• Conjugate: Biotin

Rat IL-6 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Il6

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Rat IL-6 DuoSet ELISA, 15 Plate

• B-cell differentiation factor
• B-cell stimulatory factor 2
• BSF2
• BSF-2
• CDF
• CTL differentiation factor
• HSF
• hybridoma growth factor
• IFNB2
• IFN-beta-2
• IL6
• IL-6
• Interferon beta-2
• interleukin 6 (interferon, beta 2)
• interleukin BSF-2
• interleukin-6
• MGI-2A

Background

Interleukin 6 (IL-6) is a pleiotropic, a-helical, 22-28 kDa phosphorylated and variably glycosylated cytokine that plays important roles in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression. Mature human IL-6 is 183 amino acids (aa) in length and shares 39% aa sequence identity with mouse and rat IL-6. Alternative splicing generates several isoforms with internal deletions, some of which exhibit antagonistic properties. Cells known to express IL-6 include CD8+ T cells, fibroblasts, synoviocytes, adipocytes, osteoblasts, megakaryocytes, endothelial cells (under the influence of endothelins), sympathetic neurons, cerebral cortex neurons, adrenal medulla chromaffin cells, retinal pigment cells, mast cells, keratinocytes, Langerhans cells, fetal and adult astrocytes, neutrophils, monocytes, eosinophils, colonic epithelial cells, B1 B cells and pancreatic islet beta cells. IL-6 production is generally correlated with cell activation and is normally kept in control by glucocorticoids, catecholamines, and secondary sex steroids. Normal human circulating IL-6 is in the 1 pg/mL range, with slight elevations during the menstrual cycle, modest elevations in certain cancers, and large elevations after surgery.

IL-6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL-6 R alpha) and a signal transducing subunit (gp130). IL-6 binds to IL-6 Ra, triggering IL-6 Ra association with gp130 and gp130 dimerization. gp130 is also a component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM. Soluble forms of IL-6 Ra are generated by both alternative splicing and proteolytic cleavage. In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 Ra elicit responses from gp130-expressing cells that lack cell surface IL-6 Ra. Trans-signaling enables a wider range of cell types to respond to IL-6, as the expression of gp130 is ubiquitous, while that of IL-6 Ra is predominantly restricted to hepatocytes, monocytes, and resting lymphocytes. Soluble splice forms of gp130 block trans-signaling from IL-6/IL-6 Ra but not from other cytokines that use gp130 as a co-receptor.

IL-6, along with TNF-a and IL-1, drives the acute inflammatory response. IL-6 is almost solely responsible for fever and the acute phase response in the liver, and it is important in the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. When dysregulated, it contributes to chronic inflammation in conditions such as obesity, insulin resistance, inflammatory bowel disease, arthritis, and sepsis. IL-6 modulates bone resorption and is a major effector of inflammatory joint destruction in rheumatoid arthritis through its promotion of Th17 cell development and activity. It contributes to atherosclerotic plaque development and destabilization as well as the development of inflammation-associated carcinogenesis.

Publications for IL-6 (DY506)(104)

Publications using DY506

• Kang, S;Choi, G;Kim, D;Kim, H;Cheon, C;Ko, SG; Trichosanthes kirilowii Maxim. and Bioactive Compound Cucurbitacin D Alleviate Cisplatin-Induced Peripheral Neuropathy In Vitro and In Vivo Integrative cancer therapies 2025-05-18 [PMID: 40383960] (Rat)
• Tojo, K;Yazawa, T; A high fraction of inspired oxygen does not mitigate atelectasis-induced lung tissue hypoxia or injury in experimental acute respiratory distress syndrome Scientific reports 2025-01-14 [PMID: 39809828] (Rat)
• Wu, YC;Lian, YZ;Zhao, H;Wang, L;Ning, D;Chao, JC; Ginsenosides, salidroside, and syringin complex exhibits anti-fatigue in exhaustive exercise rats International journal of medical sciences 2025-01-01 [PMID: 39744162] (Rat)
• Ergin, B;Kutucu, DE;Kapucu, A;van Dam, W;Moretto, L;Heyman, P;Ince, C; Hemoadsorption improves kidney microcirculatory oxygenation and oxygen consumption, ameliorates tubular injury, and improves kidney function in a rat model of sepsis-induced AKI Scientific reports 2024-11-18 [PMID: 39558075] (Rat)
• Souza, SS;Lopes Cruz, L;Alves-Reis, AM;Costa, VQ;Moraes-Souza, RQ;Damasceno, DC;Volpato, GT; Periodontitis and diabetes in pregnant rats: Maternal-fetal outcomes Heliyon 2024-09-15 [PMID: 39296079] (Rat)
• Chausse, B;Malorny, N;Lewen, A;Poschet, G;Berndt, N;Kann, O; Metabolic flexibility ensures proper neuronal network function in moderate neuroinflammation Scientific reports 2024-06-22 [PMID: 38909138] (Rat)
• Dutta, D;Liu, J;Xu, E;Xiong, H; Methamphetamine Enhancement of HIV-1 gp120-Mediated NLRP3 Inflammasome Activation and Resultant Proinflammatory Responses in Rat Microglial Cultures International Journal of Molecular Sciences 2024-03-22 [PMID: 38612400] (Rat)
• Ferreira, RO;Pereira, MS;Souza-Monteiro, D;Frazão, DR;de Moura, JDM;Baia-da-Silva, DC;Bittencourt, LO;Balbinot, GS;Collares, FM;Lima, MLS;de Araújo, AA;Lima, RR; Physical training attenuates systemic cytokine response and tissue damage triggered by apical periodontitis Scientific reports 2024-04-05 [PMID: 38580668] (Rat)
• Rahman, Z;Shaikh, AS;Rao, KV;Dandekar, MP; Oxyberberine protects middle cerebral artery occlusion triggered cerebral injury through TLR4/NLRP3 pathway in rats Journal of chemical neuroanatomy 2024-01-19 [PMID: 38246265] (Rat)
• Anttila, JE;Mattila, OS;Liew, HK;Mätlik, K;Mervaala, E;Lindholm, P;Lindahl, M;Lindsberg, PJ;Tseng, KY;Airavaara, M; MANF protein expression is upregulated in immune cells in the ischemic human brain and systemic recombinant MANF delivery in rat ischemic stroke model demonstrates anti-inflammatory effects Acta neuropathologica communications 2024-01-16 [PMID: 38229173] (Rat)
• Sangweni, NF;Gabuza, K;van Aarde, R;Mabasa, L;van Vuuren, D;Huisamen, B;Barry, R;Johnson, R; Doxorubicin-Induced Cardiomyopathy: A Preliminary Study on the Cardioprotective Benefits of 7-Hydroxyflavanone International journal of molecular sciences 2023-10-20 [PMID: 37895075] (Rat)
• Xiao, Q;Chen, YH;Chen, YL;Chien, YS;Hsieh, LH;Shirakawa, H;Yang, SC; Potential Benefits of Epidermal Growth Factor for Inhibiting Muscle Degrative Markers in Rats with Alcoholic Liver Damage International journal of molecular sciences 2023-05-16 [PMID: 37240190] (Rat)
• Farahzadi, R;Fathi, E;Mesbah-Namin, SA;Vietor, I; Granulocyte differentiation of rat bone marrow resident C-kit+ hematopoietic stem cells induced by mesenchymal stem cells could be considered as new option in cell-based therapy Regenerative therapy 2023-06-01 [PMID: 37206538] (Rat)
• FL Haddad, C De Oliveir, S Schmid Investigating behavioral phenotypes related to autism spectrum disorder in a gene-environment interaction model of Cntnap2 deficiency and Poly I:C maternal immune activation Frontiers in Neuroscience, 2023-03-14;17(0):1160243. 2023-03-14 [PMID: 36998729] (Rat)
• SK Tirunavall, M Kuncha, R Sistla, SB Andugulapa Targeting TGF-beta/periostin signaling by sesamol ameliorates pulmonary fibrosis and improves lung function and survival The Journal of nutritional biochemistry, 2023-03-21;0(0):109294. 2023-03-21 [PMID: 36948431] (Rat)
• NA Lage, MRB de Paiva, DV Vasconcelo, RR Machado, SL Fialho, A Silva-Cunh Efficacy and Safety Evaluation of Mometasone Furoate in Treating Ocular Inflammation Pharmaceutics, 2023-01-05;15(1):. 2023-01-05 [PMID: 36678822] (Rat)
• L Li, ZC Yao, A Parian, YH Yang, J Chao, J Yin, KJ Salimian, SK Reddy, A Zaheer, SL Gearhart, HQ Mao, FM Selaru A nanofiber-hydrogel composite improves tissue repair in a rat model of Crohn's disease perianal fistulas Science Advances, 2023-01-04;9(1):eade1067. 2023-01-04 [PMID: 36598982] (Rat)
• DF Baggio, FMR da Luz, RV Lopes, LEN Ferreira, EI Araya, JG Chichorro Sex dimorphism in Resolvin D5-induced analgesia in rat models of trigeminal pain The journal of pain, 2022-12-28;0(0):. 2022-12-28 [PMID: 36584931] (Rat)
• C Neu, Y Thiele, F Horr, C Beckers, N Frank, G Marx, L Martin, S Kraemer, E Zechendorf DAMPs Released from Proinflammatory Macrophages Induce Inflammation in Cardiomyocytes via Activation of TLR4 and TNFR International Journal of Molecular Sciences, 2022-12-08;23(24):. 2022-12-08 [PMID: 36555168] (Rat)
• I Klein, J Boenert, F Lange, B Christense, MK Wassermann, MHJ Wiesen, DN Olschewski, M Rabenstein, C Müller, HC Lehmann, GR Fink, M Schroeter, MA Rueger, SU Vay Glia from the central and peripheral nervous system are differentially affected by paclitaxel chemotherapy via modulating their neuroinflammatory and neuroregenerative properties Frontiers in Pharmacology, 2022-11-02;13(0):1038285. 2022-11-02 [PMID: 36408236] (Rat)
• RL Jayaraj, S Azimullah, KA Parekh, SK Ojha, R Beiram Effect of citronellol on oxidative stress, neuroinflammation and autophagy pathways in an in vivo model of Parkinson's disease Heliyon, 2022-11-03;8(11):e11434. 2022-11-03 [PMID: 36387498] (Rat)
• D Dominguini, M Michels, LB Wessler, EL Streck, T Barichello, F Dal-Pizzol Mitochondrial protective effects caused by the administration of mefenamic acid in sepsis Journal of Neuroinflammation, 2022-11-04;19(1):268. 2022-11-04 [PMID: 36333747] (Rat)
• R Li, S Bhandari, I Martinez-Z, JA Bruun, I Urbarova, B Smedsrød, J Simón-Sant, KK Sørensen Changes in the proteome and secretome of rat liver sinusoidal endothelial cells during early primary culture and effects of dexamethasone PLoS ONE, 2022-09-02;17(9):e0273843. 2022-09-02 [PMID: 36054185] (Rat)
• M Adeel, CC Chen, BS Lin, HC Chen, JC Liou, YT Li, CW Peng Safety of Special Waveform of Transcranial Electrical Stimulation (TES): In Vivo Assessment International Journal of Molecular Sciences, 2022-06-20;23(12):. 2022-06-20 [PMID: 35743291] (Rat)
• R Shvartsur, G Agam, S Uzzan, AN Azab Low-Dose Aspirin Augments the Anti-Inflammatory Effects of Low-Dose Lithium in Lipopolysaccharide-Treated Rats Pharmaceutics, 2022-04-20;14(5):. 2022-04-20 [PMID: 35631487] (Rat)
• SB Silva, K Honorato-S, SP Costa, TE Domingues, TMM da Cruz, CM Rodrigues, KB Costa, JM Dos Santos, VK da Silva L, TP Gaiad, AP Santos, MF Dias-Peixo, CC Coimbra, AM Dos Reis, RE Szawka, PHS Figueiredo, HS Costa, MX Oliveira, VA Mendonça, ACR Lacerda The superior beneficial effects of exercise training versus hormone replacement therapy on skeletal muscle of ovariectomized rats Scientific Reports, 2022-05-24;12(1):8764. 2022-05-24 [PMID: 35610295] (Rat)
• A Sharma, K Sanjeev, VMJ Selvanatha, M Sekar, N Harikrishn The evaluation of cytotoxicity and cytokine IL-6 production of root canal sealers with and without the incorporation of simvastatin: an invitro study BMC Oral Health, 2022-01-11;22(1):6. 2022-01-11 [PMID: 35012572] (Mouse)
• MJ Jeong, S Jeon, HS Yu, WS Cho, S Lee, D Kang, Y Kim, YJ Kim, SY Kim Exposure to Nickel Oxide Nanoparticles Induces Acute and Chronic Inflammatory Responses in Rat Lungs and Perturbs the Lung Microbiome International Journal of Environmental Research and Public Health, 2022-01-04;19(1):. 2022-01-04 [PMID: 35010784] (Rat)
• D Galleguill, Q Wang, N Steinberg, A Zaidi, G Shrivastav, K Dhami, GC Daskhan, EN Schmidt, Z Dworsky-Fr, F Giuliani, M Churchward, C Power, K Todd, A Taylor, MS Macauley, S Sipione Anti-inflammatory role of GM1 and other gangliosides on microglia Journal of Neuroinflammation, 2022-01-06;19(1):9. 2022-01-06 [PMID: 34991625] (Rat)
• A Jung, SH Kim, JY Yang, J Jeong, JK Lee, JH Oh, JH Lee Effect of Pulmonary Inflammation by Surface Functionalization of Zinc Oxide Nanoparticles Toxics, 2021-12-06;9(12):. 2021-12-06 [PMID: 34941770] (Rat)
• ME Brien, K Hughes, S Girard Prenatal administration of IL-1Ra attenuate the neurodevelopmental impacts following non-pathogenic inflammation during pregnancy Scientific Reports, 2021-12-03;11(1):23404. 2021-12-03 [PMID: 34862457] (Rat)
• ACA da Silva, JS Severo, BLB Dos Santos, PHM Mendes, LMS Nobre, AP de Oliveir, FCS Ferreira, JVR Medeiros, RC Lima-Junio, A Havt, RC Palheta-Ju, AA Dos Santos, M Tolentino Moderate Physical Exercise Activates ATR2 Receptors, Improving Inflammation and Oxidative Stress in the Duodenum of 2K1C Hypertensive Rats Frontiers in Physiology, 2021-10-14;12(0):734038. 2021-10-14 [PMID: 34777003] (Rat)
• H Peng, BT Harvey, CI Richards, K Nixon Neuron-Derived Extracellular Vesicles Modulate Microglia Activation and Function Biology, 2021-09-22;10(10):. 2021-09-22 [PMID: 34681047] (Rat)
• Q Xiao, YH Chen, SA Pratama, YL Chen, H Shirakawa, HC Peng, SC Yang The Prophylactic Effects of Glutamine on Muscle Protein Synthesis and Degradation in Rats with Ethanol-Induced Liver Damage Nutrients, 2021-08-14;13(8):. 2021-08-14 [PMID: 34444950] (Rat)
• M Guibourden, H El Khayat, N Djekkoun, H Khorsi-Cau, V Bach, PM Anton, J Gay-Quéhei Programming of intestinal homeostasis in male rat offspring after maternal exposure to chlorpyrifos and/or to a high fat diet Scientific Reports, 2021-06-01;11(1):11420. 2021-06-01 [PMID: 34075131] (Rat)
• SE Huang, E Sulistyowa, YY Chao, BN Wu, ZK Dai, JH Hsu, JL Yeh In Vitro Evaluation of the Anti-Inflammatory Effect of KMUP-1 and In Vivo Analysis of Its Therapeutic Potential in Osteoarthritis Biomedicines, 2021-05-28;9(6):. 2021-05-28 [PMID: 34071594] (Mouse)
• F ?aja, D Stakheev, O Chernyavsk, L Kubinová, J K?ížan, J Dvo?ák, P Rossmann, R Št?pánková, P Makovický, P Makovický, V Vymetalkov, P Sou?ek, P Vodi?ka, L Vodi?ková, M Levý, LE Vannucci Local Immune Changes in Early Stages of Inflammation and Carcinogenesis Correlate with the Collagen Scaffold Changes of the Colon Mucosa Cancers, 2021-05-18;13(10):. 2021-05-18 [PMID: 34070183] (Rat)
• S Schilling, B Chausse, HO Dikmen, F Almouhanna, JO Hollnagel, A Lewen, O Kann TLR2- and TLR3-activated microglia induce different levels of neuronal network dysfunction in a context-dependent manner Brain, Behavior, and Immunity, 2021-05-17;0(0):. 2021-05-17 [PMID: 34015428] (Rat)
• SJB Jesudasan, SJ Gupta, MA Churchward, KG Todd, IR Winship Inflammatory Cytokine Profile and Plasticity of Brain and Spinal Microglia in Response to ATP and Glutamate Frontiers in Cellular Neuroscience, 2021-04-06;15(0):634020. 2021-04-06 [PMID: 33889075] (Rat)
• N Perez Diaz, LA Lione, V Hutter, LS Mackenzie Co-Incubation with PPAR&beta/&delta Agonists and Antagonists Modeled Using Computational Chemistry: Effect on LPS Induced Inflammatory Markers in Pulmonary Artery International Journal of Molecular Sciences, 2021-03-19;22(6):. 2021-03-19 [PMID: 33808880] (Rat)
• VGB Brito, MS Patrocinio, MCL Sousa, AEA Barreto, SCT Frasnelli, VS Lara, CF Santos, SHP Oliveira Mast cells contribute to alveolar bone loss in Spontaneously Hypertensive Rats with periodontal disease regulating cytokines production PLoS ONE, 2021-03-04;16(3):e0247372. 2021-03-04 [PMID: 33661916] (Rat)
• JH He, RP Liu, YM Peng, Q Guo, LB Zhu, YZ Lian, BL Hu, HH Fan, X Zhang, JH Zhu Differential and paradoxical roles of new-generation antidepressants in primary astrocytic inflammation Journal of Neuroinflammation, 2021-02-18;18(1):47. 2021-02-18 [PMID: 33602262] (Rat)
• JNB Pereira, GM Murata, FT Sato, AR Marosti, CRO Carvalho, R Curi Small intestine remodeling in male Goto-Kakizaki rats Physiological Reports, 2021-02-01;9(3):e14755. 2021-02-01 [PMID: 33580916] (Rat)
• SM Davis, LA Collier, SJ Messmer, KR Pennypacke The Poststroke Peripheral Immune Response Is Differentially Regulated by Leukemia Inhibitory Factor in Aged Male and Female Rodents Oxidative Medicine and Cellular Longevity, 2020-12-10;2020(0):8880244. 2020-12-10 [PMID: 33376583] (Rat)
• H Javed, MFN Meeran, S Azimullah, L Bader Eddi, VD Dwivedi, NK Jha, S Ojha &alpha-Bisabolol, a Dietary Bioactive Phytochemical Attenuates Dopaminergic Neurodegeneration through Modulation of Oxidative Stress, Neuroinflammation and Apoptosis in Rotenone-Induced Rat Model of Parkinson's disease Biomolecules, 2020-10-08;10(10):. 2020-10-08 [PMID: 33049992] (Rat)
• YL Chen, H Shirakawa, NS Lu, HC Peng, Q Xiao, SC Yang Impacts of fish oil on the gut microbiota of rats with alcoholic liver damage J. Nutr. Biochem., 2020-09-11;86(0):108491. 2020-09-11 [PMID: 32920090] (Rat)
• M Defaye, C Nourrisson, E Baudu, A Lashermes, M Meynier, M Meleine, I Wawrzyniak, V Bonnin, J Barbier, B Chassaing, C Godfraind, A Gelot, N Barnich, D Ardid, M Bonnet, F Delbac, FA Carvalho, P Poirier Fecal dysbiosis associated with colonic hypersensitivity and behavioral alterations in chronically Blastocystis-infected rats Sci Rep, 2020-06-04;10(1):9146. 2020-06-04 [PMID: 32499543] (Rat)
• AM Baratta, NR Kanyuch, CA Cole, H Valafar, J Deslaurier, A Pocivavsek Acute sleep deprivation during pregnancy in rats: Rapid elevation of placental and fetal inflammation and kynurenic acid Neurobiol Stress, 2019-12-14;12(0):100204. 2019-12-14 [PMID: 32258253] (Rat)
• J Cui, X Guo, Q Li, N Song, J Xie Hepcidin-to-Ferritin Ratio Is Decreased in Astrocytes With Extracellular Alpha-Synuclein and Iron Exposure Front Cell Neurosci, 2020-03-10;14(0):47. 2020-03-10 [PMID: 32210768] (Rat)
• P Siriarchav, MC Kruger, MR Miller, HS Tian, FM Wolber The Preventive Effects of Greenshell Mussel (Perna canaliculus) on Early-Stage Metabolic Osteoarthritis in Rats with Diet-Induced Obesity Nutrients, 2019-07-15;11(7):. 2019-07-15 [PMID: 31311115] (Rat)
• AB Silva Risc, NIP Neto, K Gascho, M Carnier, DA de Miranda, FP Silva, VT Boldarine, M Seelaender, EB Ribeiro, LM Oyama, CM Oller do N A diet including xanthan gum triggers a pro-inflammatory response in Wistar rats inoculated with Walker 256 cells PLoS ONE, 2019-06-18;14(6):e0218567. 2019-06-18 [PMID: 31211796] (Rat)
• S Chapman, E Grauer, R Gez, I Egoz, S Lazar Time dependent dual effect of anti-inflammatory treatments on sarin-induced brain inflammation: suggested role of prostaglandins Neurotoxicology, 2019-05-13;0(0):. 2019-05-13 [PMID: 31095963] (Rat)
• P Valaskova, A Dvorak, M Lenicek, K Zizalova, N Kutinova-C, J Zelenka, M Cahova, L Vitek, L Muchova Hyperbilirubinemia in Gunn Rats is Associated with Decreased Inflammatory Response in LPS-Mediated Systemic Inflammation Int J Mol Sci, 2019-05-09;20(9):. 2019-05-09 [PMID: 31075981] (Rat)
• AB Santamarin, G Jamar, LV Mennitti, DA Ribeiro, CM Cardoso, VV de Rosso, LM Oyama, LP Pisani Polyphenols-Rich Fruit (Euterpe edulis Mart.) Prevents Peripheral Inflammatory Pathway Activation by the Short-Term High-Fat Diet Molecules, 2019-04-27;24(9):. 2019-04-27 [PMID: 31035535] (Rat)
• Y van der Me, AE Faust, ET Sakalli, CC Westrick, G Hussey, IP Conner, VLN Fu, SF Badylak, MB Steketee Matrix-bound nanovesicles prevent ischemia-induced retinal ganglion cell axon degeneration and death and preserve visual function Sci Rep, 2019-03-05;9(1):3482. 2019-03-05 [PMID: 30837658] (Rat)
• J Wang, J Chen, H Jin, D Lin, Y Chen, X Chen, B Wang, S Hu, Y Wu, Y Wu, Y Zhou, N Tian, W Gao, X Wang, X Zhang BRD4 inhibition attenuates inflammatory response in microglia and facilitates recovery after spinal cord injury in rats J. Cell. Mol. Med., 2019-02-26;0(0):. 2019-02-26 [PMID: 30809946] (Rat)
• CA Barboza, AR Fukushima, N Carrozzi, JF Machi, PMM Dourado, CT Mostarda, MC Irigoyen, L Nathanson, M Morris, EC Caperuto, B Rodrigues Cholinergic Stimulation by Pyridostigmine Bromide Before Myocardial Infarction Prevent Cardiac and Autonomic Dysfunction Sci Rep, 2019-02-21;9(1):2481. 2019-02-21 [PMID: 30792425] (Rat)
• SJ Lee, H Wang, SH Ahn, MK Son, GH Hyun, SJ Yoon, J Lee, JH Park, J Lim, SS Hong, SW Kwon Metabolomics Approach Based on Multivariate Techniques for Blood Transfusion Reactions Sci Rep, 2019-02-11;9(1):1740. 2019-02-11 [PMID: 30741955] (Rat)
• D Morales-Ca, M Callejo, B Barreira, G Mondejar-P, S Esquivel-R, S Ramos, MÁ Martín, A Cogolludo, L Moreno, F Perez-Vizc Elevated pulmonary arterial pressure in Zucker diabetic fatty rats PLoS ONE, 2019-01-28;14(1):e0211281. 2019-01-28 [PMID: 30689673] (Rat)
• WS Tan, P Arulselvan, SF Ng, CN Mat Taib, MN Sarian, S Fakurazi Improvement of diabetic wound healing by topical application of Vicenin-2 hydrocolloid film on Sprague Dawley rats BMC Complement Altern Med, 2019-01-17;19(1):20. 2019-01-17 [PMID: 30654793] (Rat)
• HM Wilson, L Cheyne, PAJ Brown, K Kerr, A Hannah, J Srinivasan, N Duniak, G Horgan, DK Dawson Characterization of the Myocardial Inflammatory Response in Acute Stress-Induced (Takotsubo) Cardiomyopathy JACC Basic Transl Sci, 2018-12-31;3(6):766-778. 2018-12-31 [PMID: 30623136] (Rat)
• WMT Kuwabara, CNF Yokota, R Curi, TC Alba-Loure Obesity and Type 2 Diabetes mellitus induce lipopolysaccharide tolerance in rat neutrophils Sci Rep, 2018-12-03;8(1):17534. 2018-12-03 [PMID: 30510205] (Rat)
• HF Filippini, PA Scalzilli, KM Costa, RDS Freitas, MM Campos Activation of trigeminal ganglion satellite glial cells in CFA-induced tooth pulp pain in rats PLoS ONE, 2018-11-12;13(11):e0207411. 2018-11-12 [PMID: 30419075] (Rat)
• RB Batacan, MJ Duncan, VJ Dalbo, GL Buitrago, AS Fenning Effect of different intensities of physical activity on cardiometabolic markers and vascular and cardiac function in adult rats fed with a high-fat high-carbohydrate diet J Sport Health Sci, 2016-08-03;7(1):109-119. 2016-08-03 [PMID: 30356452] (Rat)
• SM Davis, LA Collier, ED Winford, CC Leonardo, CT Ajmo, EA Foran, TJ Kopper, JC Gensel, KR Pennypacke Leukemia inhibitory factor modulates the peripheral immune response in a rat model of emergent large vessel occlusion J Neuroinflammation, 2018-10-15;15(1):288. 2018-10-15 [PMID: 30322390] (Rat)
• N Shologu, M Scully, JG Laffey, D O'Toole Human Mesenchymal Stem Cell Secretome from Bone Marrow or Adipose-Derived Tissue Sources for Treatment of Hypoxia-Induced Pulmonary Epithelial Injury Int J Mol Sci, 2018-09-30;19(10):. 2018-09-30 [PMID: 30274394] (Rat)
• SU Vay, LJ Flitsch, M Rabenstein, R Rogall, S Blaschke, J Kleinhaus, N Reinert, A Bach, GR Fink, M Schroeter, MA Rueger The plasticity of primary microglia and their multifaceted effects on endogenous neural stem cells in vitro and in vivo J Neuroinflammation, 2018-08-13;15(1):226. 2018-08-13 [PMID: 30103769] (Rat)
• AB Santamarin, G Jamar, LV Mennitti, VV de Rosso, HC Cesar, LM Oyama, LP Pisani The Use of Ju�ara (Euterpe edulis Mart.) Supplementation for Suppression of NF-?B Pathway in the Hypothalamus after High-Fat Diet in Wistar Rats Molecules, 2018-07-21;23(7):. 2018-07-21 [PMID: 30037112] (Rat)
• C Chaiyasut, S Woraharn, BS Sivamaruth, N Lailerd, P Kesika, S Peerajan Lactobacillus fermentum HP3-Mediated Fermented Hericium erinaceus Juice as a Health Promoting Food Supplement to Manage Diabetes Mellitus J Evid Based Integr Med, 2018-01-01;23(0):2515690X18765. 2018-01-01 [PMID: 29619846] (Rat)
• GS Bassi, L Ulloa, VR Santos, F Del Vecchi, P Delfino-Pe, GJ Rodrigues, JA Castania, FQ Cunha, HC Salgado, TM Cunha, N Garcia-Cai, A Kanashiro Cortical stimulation in conscious rats controls joint inflammation Prog. Neuropsychopharmacol. Biol. Psychiatry, 2018-03-06;0(0):. 2018-03-06 [PMID: 29522782] (Rat)
• LV Mennitti, LM Oyama, AB Santamarin, CMDPO do Nascime, LP Pisani Early exposure to distinct sources of lipids affects differently the development and hepatic inflammatory profiles of 21-day-old rat offspring J Inflamm Res, 2018-01-18;11(0):11-24. 2018-01-18 [PMID: 29403301] (Rat)
• YW Chien, HC Peng, YL Chen, MH Pai, HY Wang, HL Chuang, SC Yang Different Dietary Proportions of Fish Oil Regulate Inflammatory Factors but Do Not Change Intestinal Tight Junction ZO-1 Expression in Ethanol-Fed Rats Mediators Inflamm., 2017-12-13;2017(0):5801768. 2017-12-13 [PMID: 29386752] (Rat)
• RK Vella, DJ Jackson, AS Fenning ?9-Tetrahydrocannabinol Prevents Cardiovascular Dysfunction in STZ-Diabetic Wistar-Kyoto Rats Biomed Res Int, 2017-10-18;2017(0):7974149. 2017-10-18 [PMID: 29181404] (Rat)
• OC Bezerra, CM França, JA Rocha, GA Neves, PRM Souza, M Teixeira G, C Malfitano, TCA Loleiro, PM Dourado, S Llesuy, K de Angelis, MCC Irigoyen, L Ulloa, FM Consolim-C Cholinergic Stimulation Improves Oxidative Stress and Inflammation in Experimental Myocardial Infarction Sci Rep, 2017-10-20;7(1):13687. 2017-10-20 [PMID: 29057895] (Rat)
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FAQs for IL-6 (DY506). (Showing 1 - 2 of 2 FAQs).

1. I was wondering if you know of any blocking antibodies against IL-6 or VEGF-C that can be used in cell culture to quench these cytokines?
   • We have no antibodies that are currently known to show blocking antibodies to VEGF-C. Please see this link to our IL-6 antibodies with blocking/neutralizing activity can be found at this link.
2. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: Il6