RARRES3 Antibody [Alexa Fluor® 750]

• Reactivity: Hu
• Applications: ICC/IF
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Alexa Fluor 750

RARRES3 Antibody [Alexa Fluor® 750] Summary

• Immunogen: E. coli-derived recombinant human RARRES3
  Asp12-Lys134
  Accession # Q9UL19
• Specificity: Detects human RARRES3 in direct ELISAs. In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) RARRES1 and rhLatexin is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for RARRES3 Antibody [Alexa Fluor® 750]

• HRASLS4
• PLA1/2-3
• RARRES3
• RAR-responsive protein TIG3
• retinoic acid receptor responder (tazarotene induced) 3
• retinoic acid receptor responder protein 3
• retinoic acid-inducible gene 1
• Retinoid-inducible gene 1 protein
• RIG1
• Tazarotene-induced gene 3 protein
• TIG3
• TIG3MGC8906

Background

RARRES3 (Retinoic acid receptor responder 3; also Tig3) is an 18-20 kDa member of the lecithin retinol acyltransferase family of molecules. It is widely expressed, particularly in keratinocytes, and is considered to have multiple functions. These include phospholipase A activity and an ability to both activate type I transglutaminase, and inhibit Ras activation Human RARRES3 is 164 amino acids (aa) in length. It contains a catalytic residue at Cys113, and a hydrophobic membrane-anchoring domain between aa 134-164. Within the cell, RARRES3 appears to be equally distributed between membrane and soluble fractions. RARRES3 is also reported to form higher order multimers. One potential isoform exists that shows a 26 aa substitution for aa 131-164. No meaningful structural ortholog of RARRES3 exists in rodent.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.