RANK/TNFRSF11A Antibody (R12-31) [Biotin]

Product Discontinued

RANK/TNFRSF11A Antibody (R12-31) [Biotin] Summary

• Immunogen: The immunogen was the full length version of the protein: RANK (R12-31)
• Specificity: RANK (R12-31)
• Isotype: IgG2a Kappa
• Clonality: Monoclonal
• Host: Rat
• Gene: TNFRSF11A
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 1:10-1:1000
• Application Notes: Flow Cytometry For immunofluorescent staining, the suggested use of this reagent is: 1.0 microgram per one million cells in 100 microliter volume.
• Readout System:
  • Streptavidin Native Protein NBP2-29367
  • Streptavidin Native Protein NBP2-29370
  • Streptavidin Native Protein NBP2-29371

Reactivity Notes

Mouse.

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: Aqueous buffer, may contain carrier protein/stabilizer (proprietary)
• Preservative: 0.09% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Protein A or G purified

Alternate Names for RANK/TNFRSF11A Antibody (R12-31) [Biotin]

• CD265 antigen
• CD265
• FEO
• loss of heterozygosity, 18, chromosomal region 1
• ODFR
• ODFROSTS
• OFE
• OPTB7
• Osteoclast differentiation factor receptor
• PDB2
• RANK
• RANKLOH18CR1
• Receptor activator of NF-KB
• receptor activator of nuclear factor-kappa B
• TNFRSF11A
• TRANCE R
• TRANCER
• tumor necrosis factor receptor superfamily member 11A
• tumor necrosis factor receptor superfamily, member 11a, activator of NFKB
• tumor necrosis factor receptor superfamily, member 11a, NFKB activator

Background

The R12-31 monoclonal antibody reacts with mouse RANK (Receptor activator of NF-kappaB), a recently cloned member of the TNFR superfamily with no significant homology to other members of this family. RANK ligand (RANKL/TRANCE/ OPGL) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival. The cytoplasmic domain of RANK interacts with TRAF2, TRAF5 and TRAF6. Overexpression of RANK activates NF-kappaB and c-Jun-terminal kinase (JNK) pathways. Recent studies have shown that RANK interaction with TRAF6 activates NF-kappaB, whereas JNK activation is mediated through binding of RANK to TRAF2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TNFRSF11A